Psychosocial factors and chronic spontaneous urticaria: a systematic review
Open accessAbstract
BACKGROUND: Chronic spontaneous urticaria (CSU) is one of the most costly allergic conditions challenging physicians as well as patients and their families. Despite evident lacunae in the understanding of the pathogenesis, at least some findings suggest that psychosocial factors likely contribute to the development and exacerbation of CSU. We aim to assess the contribution of psychological factors to CSU. METHODS: Systematic search of PubMed and OVID/Medline databases was conducted from 1 January 1935 to 1 January 2012. Studies selected include original research in English, Spanish and French exploring the association between CSU and psychosocial factors. Two investigators independently reviewed all titles and abstracts to identify potentially relevant articles and resolved discrepancies by repeated review and discussion and arbitration of a third reviewer. Quality of systematic reviews and meta-analyses was assessed using a measure based on the Newcastle-Ottawa Scale and psychological conditions of CSU patients. RESULTS: We identified 114 eligible studies spanning 77 years and featuring 17 reviews, 67 studies related to neither CSU nor psychosocial factors, and eight studies that provided either no prevalence estimates or insufficient sample size. Pooling effect sizes using random effects, analyses revealed that, despite large heterogeneity (I(2) of 97.60%), psychosocial factors had a prevalence of 46.09% (95% confidence interval, 44.01%, 48.08%). CONCLUSION: Future research needs to better establish the contribution of psychosocial factors to the pathogenesis and exacerbation of CSU, and explore the possible benefit of behavioural interventions to the development of new management strategies.
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Anxiety disorders, somatoform disorder, and depression are the most frequently reported psychiatric disorders in patients with CU.
“Anxiety disorders, somatoform disorder, and depression are the most frequently reported psychiatric disorders in patients with CU 12,13 .”
From Could distress tolerance levels be associated with the severity of chronic spontaneous urticaria? (2022) · cites this paper as [12]
The Results of meta-analysis section (pp. 136–138) describes anxiety and depression as prominent psychopathology in chronic urticaria and reports higher somatization scores than in controls. It does not establish that somatoform disorder is a frequently reported diagnosis or rank those three disorders as the most frequent; its pooled estimate concerns psychosocial factors collectively. (LLM, conf=0.84)
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Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis
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Could distress tolerance levels be associated with the severity of chronic spontaneous urticaria?
Göçer Gürok, N., Gürok, M. G., & Öztürk, S. (2022) · TURKDERM · doi:10.4274/turkderm.galenos.2022.46793
- Authors
- Ben‐Shoshan, M., Blinderman, I., & Raz, A.
- Affiliations
- McGill University Health Centre (CA)
- Jewish General Hospital (CA)
- Corresponding author
- Raz, A.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2012-11-12
- Volume
- 68
- Issue
- 2
- Pages
- 131-141
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2172166516
- Cited by
- 86
- References
- 57
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 9 · 2016: 6 · 2015: 9 · 2014: 2 · 2013: 4
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Rheumatology › Urticaria and Related Conditions
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- chronic spontaneous urticaria, psychosocial factors, psychological factors, prevalence, urticaria pathogenesis, behavioral interventions, quality of evidence
- MeSH terms
- Behavior Therapy, Chronic Disease, Cross-Sectional Studies, Female, Humans, Male, Prognosis, Psychology, Quebec, Reference Values, Severity of Illness Index, Urticaria, Prevalence, Confidence Intervals, Odds Ratio, Case-Control Studies, Disease Progression, Needs Assessment
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