Effect of oxandrolone therapy on adult height in Turner syndrome patients treated with growth hormone: a meta-analysis

Sheanon, Nicole M.; Backeljauw, Philippe F.

doi:10.1186/s13633-015-0013-3

Cited by 31Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesGrowth Hormone and Insulin-like Growth FactorsSexual Differentiation and Disorders

Effect of oxandrolone therapy on adult height in Turner syndrome patients treated with growth hormone: a meta-analysis

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Sheanon, Nicole M., Backeljauw, Philippe F.·2015·International Journal of Pediatric Endocrinology

DOI 10.1186/s13633-015-0013-3PMC PMC4551522

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Abstract

Turner syndrome is a chromosomal abnormality in which there is complete or partial absence of the X chromosome. Turner syndrome effects 1 in every 2000 live births. Short stature is a cardinal feature of Turner Syndrome and the standard treatment is recombinant human growth hormone. When growth hormone is started at an early age a normal adult height can be achieved. With delayed diagnosis young women with Turner Syndrome may not reach a normal height. Adjuvant therapy with oxandrolone is used but there is no consensus on the optimal timing of treatment, the duration of treatment and the long term adverse effects of treatment. The objective of this review and meta-analysis is to examine the effect of oxandrolone on adult height in growth hormone treated Turner syndrome patients. Eligible trials were identified by a literature search using the terms: Turner syndrome, oxandrolone. The search was limited to English language randomized-controlled trials after 1980. Twenty-six articles were reviewed and four were included in the meta-analysis. A random effects model was used to calculate an effect size and confidence interval. The pooled effect size of 2.0759 (95 % CI 0.0988 to 4.0529) indicates that oxandrolone has a positive effect on adult height in Turner syndrome when combined with growth hormone therapy. In conclusion, the addition of oxandrolone to growth hormone therapy for treatment of short stature in Turner syndrome improves adult height. Further studies are warranted to investigate if there is a subset of Turner syndrome patients that would benefit most from growth hormone plus oxandrolone therapy, and to determine the optimal timing and duration of such therapy.

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Systematic reviews confirm a positive effect of oxandrolone on adult height gain (2-4 cm).
“and systematic reviews250,251 confirm a positive effect on adult height gain (2-4 cm).”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [251]

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Authors: Sheanon, N. M., & Backeljauw, P. F.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
Corresponding author: Sheanon, Nicole M.
ORCID: Sheanon, Nicole M.
Backeljauw, Philippe F.
Venue: International Journal of Pediatric Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2015-08-26
Volume: 2015
Issue: 1
Pages: 18-18
ISSN: 1687-9848 (ISSN-L)
1687-9856
DOI: 10.1186/s13633-015-0013-3
PMC: PMC4551522
OpenAlex: W2145915957
Cited by: 31
References: 35
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 1
FWCI: 0.25
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: International Journal of Pediatric Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (UL1TR001425)
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK063929)
National Institute of Environmental Health Sciences (T32ES010957)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: Turner syndrome, oxandrolone, adult height, growth hormone therapy, short stature

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Effect of oxandrolone therapy on adult height in Turner syndrome patients treated with growth hormone: a meta-analysis

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