The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Gluten in pharmaceutical products: a scoping review
Open accessAbstract
Background: Celiac disease (CD) is one of the most common gluten-related disorders. Although the only effective treatment is a strict gluten-free diet, doubts remain as to whether healthcare professionals take this restriction into consideration when prescribing and dispensing medicines to susceptible patients. This scoping review aimed to find out the current evidence for initiatives that either describe the gluten content of medicines or intend to raise awareness about the risk of prescribing and dispensing gluten-containing medicines in patients with CD and other gluten-related disorders. Methods: A scoping review was conducted using three search strategies in PubMed/MEDLINE, TripDatabase and Web of Science in April 2021, following the PRISMA extension for scoping reviews (PRISMA-ScR). References from included articles were also examined. Two researchers screened the articles and results were classified according to their main characteristics and outcomes, which were grouped according to the PCC (Population, Concept and Context) framework. The initiatives described were classified into three targeted processes related to gluten-containing medicines: prescription, dispensation and both prescription and dispensation. Results: We identified a total of 3146 records. After the elimination of duplicates, 3062 articles remained and ultimately 13 full texts were included in the narrative synthesis. Most studies were conducted in the US, followed by Canada and Australia, which each published one article. Most strategies were focused on increasing health professional’s knowledge of gluten-containing/gluten-free medications (n = 8), which were basically based on database development from manufacturer data. A wide variability between countries on provided information and labelling of gluten-containing medicines was found. Conclusion: Initiatives regarding the presence of gluten in medicines, including, among others, support for prescribers, the definition of the role of pharmacists, and patients’ adherence problems due to incomplete labelling of the medicines, have been continuously developed and adapted to the different needs of patients. However, information is still scarce, and some aspects have not yet been considered, such as effectiveness for the practical use of solutions to support healthcare professionals.
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“Most likely, the amounts are minimal considered the low amounts of wheat starch used in medical drugs resulting in a low daily dose of gluten (80,81).”
From Gluten-free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease. (2024) · cites this paper as [80]
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PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation
Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., et al. (2018) · Annals of Internal Medicine · doi:10.7326/m18-0850 · Cited by 43,565
Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis
Singh, P., Arora, A., Strand, T. A., Leffler, D. A., Catassi, C., Green, P. H., Kelly, C. P., Ahuja, V., & Makharia, G. K. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.06.037 · Cited by 1,743
Lebwohl, B., Sanders, D. S., & Green, P. H. R. (2018) · The Lancet · doi:10.1016/s0140-6736(17)31796-8 · Cited by 1,065
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Cited by
Sorted by citations
Luque, V., Crespo‐Escobar, P., Hård af Segerstad, E. M., Koltai, T., Norsa, L., Roman, E., Vreugdenhil, A., Fueyo‐Díaz, R., & Ribes‐Koninckx, C. (2024) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12079 · Cited by 44
Metadata
- Authors
- Lizano-Díez, I., Mariño, E. L., & Modamio, P.
- Affiliations
- Universitat de Barcelona (ES)
- Corresponding author
- Modamio, Pilar
- Venue
- Systematic Reviews
- Published
- 2021-08-07
- Volume
- 10
- Issue
- 1
- Pages
- 218-218
- ISSN
- 2046-4053 (ISSN-L)
- PMC
- PMC8349483
- OpenAlex
- W3190780165
- Cited by
- 12
- References
- 3
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 3
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Systematic Reviews (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- gluten, pharmaceutical products, celiac disease, gluten-related disorders, drug labeling, drug prescribing, dispensing, pharmacist role, health professionals' knowledge, medication adherence
- MeSH terms
- Celiac Disease, Pharmaceutical Preparations, Glutens, Humans, Pharmacists, Diet, Gluten-Free
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- Lizano-Díez, I., Mariño, E. L., & Modamio, P. (2021). Gluten in pharmaceutical products: a scoping review. Systematic Reviews. https://doi.org/10.1186/s13643-021-01772-9
