The ginsenoside Rg2 downregulates MMP-1 expression in keratinocyte (HaCaT)-conditioned medium-treated human fibroblasts (Hs68)
Open accessAbstract
Keratinocytes exposed to UVB induce the production of cytokines, which activate fibroblasts and increase the expression of matrix metalloproteinases (MMPs). The increased expression of MMPs leads to connective tissue damage and wrinkle formation, resulting in skin aging. In this study, we used human dermal fibroblasts cultured in UVB-irradiated keratinocyte-conditioned medium (UV CM) to investigate the potential anti-aging effects of the ginsenoside Rg2 on skin. The inhibitory effect of Rg2 on the MMP-1 gene and protein was determined by real-time PCR and ELISA. We also examined the expression levels of proteins in the mitogen-activated protein kinase (MAPK) signaling pathway using western blotting, to elucidate the underlying mechanism of the inhibitory effect of Rg2. Rg2 inhibited MMP-1 mRNA and protein expression in a concentration-dependent manner. We found that Rg2 inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) but not that of p38. Therefore, our results suggest that Rg2 is a potential material for the prevention and treatment of photoaging.
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Ginsenoside Rg2 (1) and ginsenoside Rg1 (4) have exhibited anti-aging effects in Hs68 and HaCaT cells, respectively, related to a reduction in MMP-1 expression and ROS.
“In previous studies, ginsenoside Rg2 (1) and ginsenoside Rg1 (4) have exhibited anti-aging effects in Hs68 and HaCaT cells, respectively. These were related to a reduction in MMP-1 expression and ROS [17,31].”
From Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage (2024) · cites this paper as [17]
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Cites
Baumann, L. (2007) · The Journal of Pathology · doi:10.1002/path.2098 · Cited by 675 · see citing works
Gilchrest, B. A. (2013) · Journal of Investigative Dermatology · doi:10.1038/skinbio.2013.176 · Cited by 215 · see citing works
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Research works printed but not linked: 1
- Lu J, Guo JH, Tu XL, Zhang C, Zhao M, Zhang QW, Gao FH (2016) Tiron inhibits UVB-induced AP-binding sites transcriptional activation on MMP-1 and MMP-3 promoters by MAPK signaling pathway in human der- mal fibroblasts. PLoS ONE 11(8):e0159998. https:// doi. org/ 10. 1371/ journ al. pone. 01599 98 · DOI · Paper page
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Kang, M., Park, S., Son, S.-R., Noh, Y., Jang, D. S., & Lee, S. (2024) · Molecules · doi:10.3390/molecules29225479 · Cited by 23 · see citing works
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- Authors
- Oh, S.-R., Park, S.-K., Lee, P., & Kim, Y.-M.
- Affiliations
- Semyung University (KR)
- Corresponding author
- Kim, Yong-Min
- Venue
- Applied Biological Chemistry
- Published
- 2023-12-06
- Volume
- 66
- Issue
- 1
- ISSN
- 0368-2897 (ISSN-L)
- 2468-0842
- OpenAlex
- W4389389141
- Cited by
- 12
- References
- 2
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Applied Biological Chemistry (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- ginsenoside Rg2, MMP-1, photoaging, skin aging, UVB irradiation, dermal fibroblasts, MAPK signaling, ERK1/2 phosphorylation, JNK phosphorylation, anti-aging agents, ginseng
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