The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
A perspective on multi‐target drug discovery and design for complex diseases
Open accessAbstract
Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.
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Cited by
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Self-citation
Metadata
- Authors
- Ramsay, R. R., Popovic‐Nikolic, M. R., Nikolic, K., Uliassi, E., & Bolognesi, M. L.
- Venue
- Clinical and Translational Medicine
- Publisher
- Wiley
- Published
- 2018-01-17
- Volume
- 7
- Issue
- 1
- Pages
- 3-3
- ISSN
- 2001-1326 (ISSN-L)
- OpenAlex
- W2783897572
- Cited by
- 718
- References
- 101
- FWCI
- 55.04
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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