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Cited by 132Nutrition, Genetics, and DiseaseGut microbiota and healthPharmacogenetics and Drug Metabolism

The DOI matches its Crossref record; 264 of the 264 references it cites were found in a registry or an index.

Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living

Open access
Lagoumintzis, George, Patrinos, George P.·2023·Human Genomics
DOI 10.1186/s40246-023-00561-wPMC PMC10704648
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Abstract

The unique physiological and genetic characteristics of individuals influence their reactions to different dietary constituents and nutrients. This notion is the foundation of personalized nutrition. The field of nutrigenetics has witnessed significant progress in understanding the impact of genetic variants on macronutrient and micronutrient levels and the individual's responsiveness to dietary intake. These variants hold significant value in facilitating the development of personalized nutritional interventions, thereby enabling the effective translation from conventional dietary guidelines to genome-guided nutrition. Nevertheless, certain obstacles could impede the extensive implementation of individualized nutrition, which is still in its infancy, such as the polygenic nature of nutrition-related pathologies. Consequently, many disorders are susceptible to the collective influence of multiple genes and environmental interplay, wherein each gene exerts a moderate to modest effect. Furthermore, it is widely accepted that diseases emerge because of the intricate interplay between genetic predisposition and external environmental influences. In the context of this specific paradigm, the utilization of advanced "omic" technologies, including epigenomics, transcriptomics, proteomics, metabolomics, and microbiome analysis, in conjunction with comprehensive phenotyping, has the potential to unveil hitherto undisclosed hereditary elements and interactions between genes and the environment. This review aims to provide up-to-date information regarding the fundamentals of personalized nutrition, specifically emphasizing the complex triangulation interplay among microbiota, dietary metabolites, and genes. Furthermore, it highlights the intestinal microbiota's unique makeup, its influence on nutrigenomics, and the tailoring of dietary suggestions. Finally, this article provides an overview of genotyping versus microbiomics, focusing on investigating the potential applications of this knowledge in the context of tailored dietary plans that aim to improve human well-being and overall health.

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Fig. 1 Aspects of personalized nutrition concept affecting individual’s healthy life and well-being
Fig. 1 Aspects of personalized nutrition concept affecting individual’s healthy life and well-beingCC BY · PubMed Central
Fig. 2 Dietary fiber intake and SCFA production
Fig. 2 Dietary fiber intake and SCFA productionCC BY · PubMed Central
Fig. 3 General aspects of the most common interventions in manipulating gut microbiome composition and its proper functionality. A: Probiotics, B: Prebiotics, C: Fecal Microbiota Transplantation (FMT)
Fig. 3 General aspects of the most common interventions in manipulating gut microbiome composition and its proper functionality. A: Probiotics, B: Prebiotics, C: Fecal Microbiota Transplantation (FMT)CC BY · PubMed Central

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Research works printed but not linked: 4

  1. American Chemical Society National Historic Chemical Landmarks. The Discovery of Vitamin C by Albert Szent-Györgyi. Accessed 20 Jul 2023 from http://www.acs.org/content/acs/en/education/whatischemistry/landmarks/szentgyorgyi.html
  2. Zhang H, Chen Y, Wang Z, Xie G, Liu M, Yuan B, Chai H, Wang W, Cheng P. Implications of gut microbiota in neurodegenerative diseases. Front Immunol. 2022;13:785644. · DOI
  3. Gophna U. Microbiology. Guts Dietary Habits Sci. 2011;334:45–6.
  4. Zmora N, Zilberman-Schapira G, Suez J, Mor U, Dori-Bachash M, Bashiardes S, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell. 2018;174:1388. https://doi.org/10.1016/j.cell.2018.08.041. · DOI · Paper page

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Metadata

Authors
Lagoumintzis, G., & Patrinos, G. P.
Affiliations
University of Patras (GR)
Corresponding author
  • Lagoumintzis, George
  • Patrinos, George P.
ORCID
Venue
Human Genomics
Publisher
Springer Science and Business Media LLC
Published
2023-12-08
Volume
17
Issue
1
Pages
109-109
ISSN
  • 1473-9542 (ISSN-L)
  • 1479-7364
DOI
10.1186/s40246-023-00561-w
PMC
PMC10704648
OpenAlex
W4389463305
Cited by
132
References
264
Citations by year
2026: 64 · 2025: 55 · 2024: 13
FWCI
5.09
Type
journal article
Language
en
Open access
Licence
Locations
  • Human Genomics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Patras
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
personalized nutrition, nutrigenomics, nutrigenetics, metabolomics, microbiome, gut microbiota, gene-environment interaction, polygenic traits, dietary metabolites, healthy living
MeSH terms
Healthy Lifestyle, Humans, Nutritional Status, Genetic Predisposition to Disease, Nutrigenomics, Metabolomics

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