The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
The immune system in cancer metastasis: friend or foe?
Open accessAbstract
Metastatic disease is the leading cause of death among cancer patients and involves a complex and inefficient process. Every step of the metastatic process can be rate limiting and is influenced by non-malignant host cells interacting with the tumor cell. Over a century ago, experiments first indicated a link between the immune system and metastasis. This phenomenon, called concomitant immunity, indicates that the primary tumor induces an immune response, which may not be sufficient to destroy the primary tumor, but prevents the growth of a secondary tumor or metastases. Since that time, many different immune cells have been shown to play a role in both inhibiting and promoting metastatic disease. Here we review classic and new observations, describing the links between the immune system and metastasis that inform the development of cancer therapies.
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Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research
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Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer
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Neoantigen: A New Breakthrough in Tumor Immunotherapy
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Metadata
- Authors
- Janssen, L. M. E., Ramsay, E. E., Logsdon, C. D., & Overwijk, W. W.
- Venue
- Journal for ImmunoTherapy of Cancer
- Publisher
- BMJ
- Published
- 2017-10-17
- Volume
- 5
- Issue
- 1
- Pages
- 79-79
- ISSN
- 2051-1426 (ISSN-L)
- OpenAlex
- W2760780444
- Cited by
- 292
- References
- 121
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- gold
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- Janssen, L. M. E., Ramsay, E. E., Logsdon, C. D., & Overwijk, W. W. (2017). The immune system in cancer metastasis: friend or foe? Journal for ImmunoTherapy of Cancer. https://doi.org/10.1186/s40425-017-0283-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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