The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Cytokine release syndrome
Open accessAbstract
During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific T-cell engaging (BiTE) single-chain antibody constructs and chimeric antigen receptor (CAR) T cells have shown remarkable efficacy in clinical trials and some of these agents have already received regulatory approval. However, along with growing experience in the clinical application of these potent immunotherapeutic agents comes the increasing awareness of their inherent and potentially fatal adverse effects, most notably the cytokine release syndrome (CRS). This review provides a comprehensive overview of the mechanisms underlying CRS pathophysiology, risk factors, clinical presentation, differential diagnoses, and prognostic factors. In addition, based on the current evidence we give practical guidance to the management of the cytokine release syndrome.
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Cites
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Cited by
A guide to cancer immunotherapy: from T cell basic science to clinical practice
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The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
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Cytokines: From Clinical Significance to Quantification
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Metadata
- Authors
- Shimabukuro-Vornhagen, A., Gödel, P., Subklewe, M., Stemmler, H. J., Schlößer, H. A., Schlaak, M., Kochanek, M., Böll, B., & von Bergwelt-Baildon, M. S.
- Venue
- Journal for ImmunoTherapy of Cancer
- Publisher
- BMJ
- Published
- 2018-06-15
- Volume
- 6
- Issue
- 1
- Pages
- 56-56
- ISSN
- 2051-1426 (ISSN-L)
- OpenAlex
- W2808166290
- Cited by
- 1,656
- References
- 24
- FWCI
- 60.75
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shimabukuro-Vornhagen, A., Gödel, P., Subklewe, M., Stemmler, H. J., Schlößer, H. A., Schlaak, M., Kochanek, M., Böll, B., & von Bergwelt-Baildon, M. S. (2018). Cytokine release syndrome. Journal for ImmunoTherapy of Cancer. https://doi.org/10.1186/s40425-018-0343-9
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
