The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases
Open accessAbstract
Background: Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new promising approach for reprogramming resident cells in both acute and chronic kidney disease. Forty CKD patients stage III and IV (eGFR 15–60 mg/ml) have been divided into two groups; twenty patients as treatment group “A” and twenty patients as a matching placebo group “B”. Two doses of MSC-derived extracellular vesicles had been administered to patients of group “A”. Blood urea, serum creatinine, urinary albumin creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) have been used to assess kidney functions and TNF-α, TGF-β1 and IL-10 have been used to assess the amelioration of the inflammatory immune activity. Results: Participants in group A exhibited significant improvement of eGFR, serum creatinine level, blood urea and UACR. Patients of the treatment group “A” also exhibited significant increase in plasma levels of TGF-β1, and IL-10 and significant decrease in plasma levels of TNF-α. Participants of the control group B did not show significant improvement in any of the previously mentioned parameters at any time point of the study period. Conclusion: Administration of cell-free cord-blood mesenchymal stem cells derived extracellular vesicles (CF-CB-MSCs-EVs) is safe and can ameliorate the inflammatory immune reaction and improve the overall kidney function in grade III-IV CKD patients.
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Cited by
Extracellular vesicles as a next-generation drug delivery platform
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Advances in therapeutic applications of extracellular vesicles
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Exosomes as mediators of intercellular crosstalk in metabolism
Isaac, R., Reis, F. C. G., Ying, W., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.006 · Cited by 820
Therapeutically harnessing extracellular vesicles
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A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles
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Metadata
- Authors
- Nassar, W., El-Ansary, M., Sabry, D., Mostafa, M. A., Fayad, T., Kotb, E., Temraz, M., Saad, A.-N., Essa, W., & Adel, H.
- Venue
- Biomaterials Research
- Published
- 2016-03-15
- Volume
- 20
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1226-4601 (ISSN-L)
- 2055-7124
- OpenAlex
- W2487947432
- Cited by
- 502
- References
- 30
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nassar, W., El-Ansary, M., Sabry, D., Mostafa, M. A., Fayad, T., Kotb, E., Temraz, M., Saad, A.-N., Essa, W., & Adel, H. (2016). Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases. Biomaterials Research. https://doi.org/10.1186/s40824-016-0068-0
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