The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles
Open accessAbstract
Extracellular vesicles (EVs) are small cargo‐bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell‐to‐cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to take stock and look back on how the field started, and has since exploded into its current state. Here we review the early experiments, summarise key findings that have propelled the field, describe the growth of an organised EV community, discuss the current state of the field, and identify key challenges that need to be addressed.
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Cites
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Self-citationB lymphocytes secrete antigen-presenting vesicles.
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Self-citationRaise standards for preclinical cancer research
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Reassessment of exosome composition
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“Later, Rose Johnstone used the term ‘exosome’ to describe vesicles released following the fusion of MVBs with the plasma membrane (Johnstone et al., 1987), and this has become ISEV’s recommended term for this type of vesicle (Théry et al., 2018).”
BackgroundMethodRoutes and mechanisms of extracellular vesicle uptake
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Cited by
Extracellular vesicles as personalized medicine
Beetler, D. J., Di Florio, D. N., Bruno, K. A., Ikezu, T., March, K. L., Cooper, L. T., Wolfram, J., & Fairweather, D. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101155 · Cited by 101
Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review
Wu, K.-C., Chang, Y.-H., Ding, D.-C., & Lin, S.-Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312911 · Cited by 33
Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence
Zhang, J., Ma, B., Wang, Z., Chen, Y., Li, C., & Dong, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01292-0 · Cited by 17
From gains to liver pain: when exercise training goes too far
Burke, B. I., McCarthy, J. J., & Ismaeel, A. (2025) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2025.36 · Cited by 1
Metadata
- Authors
- Couch, Y., Buzàs, E. I., Di Vizio, D., Gho, Y. S., Harrison, P., Hill, A. F., Lötvall, J., Raposo, G., Stahl, P. D., Théry, C., Witwer, K. W., & Carter, D. R. F.
- Venue
- Journal of Extracellular Vesicles
- Publisher
- Wiley
- Published
- 2021-12
- Volume
- 10
- Issue
- 14
- Pages
- e12144-e12144
- ISSN
- 2001-3078 (ISSN-L)
- OpenAlex
- W4200180613
- Cited by
- 566
- References
- 103
- FWCI
- 20.53
- Type
- journal article
- Language
- en
- Open access
- gold
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- Couch, Y., Buzàs, E. I., Di Vizio, D., Gho, Y. S., Harrison, P., Hill, A. F., Lötvall, J., Raposo, G., Stahl, P. D., Théry, C., Witwer, K. W., & Carter, D. R. F. (2021). A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles. Journal of Extracellular Vesicles. https://doi.org/10.1002/jev2.12144
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