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Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering
Open accessAbstract
Background: In recent years, three-dimensional (3D) printing has begun to be widely used in tissue engineering. Natural biomaterials have been employed to overcome the limitations of synthetic polymers. However, their low mechanical strength and poor printability are major disadvantages. Photocrosslinking is the most promising fabrication strategy because it is non-invasive and easy to control light intensity and exposure. In this article, developments of photocrosslinkable natural biomaterials in the field of 3D printing are reviewed. Main body: Photocrosslinkable biomaterials can be broadly classified into materials that use ultraviolet (UV) and visible lights. Many natural biomaterials such as gelatin, hydroxyapatite, silk fibroin, and pectin have been modified through acrylation, crosslinked by 365 nm UV light, and 3D printed. Riboflavin could also be used to crosslink and print collagen or decellularized extracellular matrix (dECM). In the case of silk-like aneroin and modified gelatin, crosslinking is possible by forming a dityrosine bond using 452 nm visible light. Conclusion: Despite the tremendous researches on the developments of photocrosslinkable 3D printing natural biomaterials, further efforts are necessary to develop source biomaterials with excellent biological functions and sufficient mechanical integrity.
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![Fig. 1 Elastic modulus of native tissues and organs [13, 14]](/paper-figures/42f048a0f905486dbfe8ecbc6c2fcbdc/recent-advances-in-the-development-of-nature-derived-photocrosslinkable-figure-1.jpg)
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“However, after crosslinking, unreacted acryl groups provoke immune responses [214].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [214]
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Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
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“GelMA has attracted much attention in the field of tissue engineering due to its good bioactivity and physico-chemical properties which were achieved by UV light-mediated photocrosslinking [34].”
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Sorted by citations
Kasravi, M., Ahmadi, A., Babajani, A., Mazloomnejad, R., Hatamnejad, M. R., Shariatzadeh, S., Bahrami, S., & Niknejad, H. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00348-z · Cited by 316
Injectable hydrogels as emerging drug-delivery platforms for tumor therapy
Cheng, Y., Zhang, H., Wei, H., & Yu, C.-Y. (2024) · Biomaterials Science · doi:10.1039/d3bm01840g · Cited by 65
Photocrosslinkable silk-based biomaterials for regenerative medicine and healthcare applications
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Metadata
- Authors
- Choi, G., & Cha, H. J.
- Affiliations
- Pohang University of Science and Technology (KR)
- Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, South Korea.
- Venue
- Biomaterials Research
- Published
- 2019-11-19
- Volume
- 23
- Issue
- 1
- Pages
- 18-18
- ISSN
- 1226-4601 (ISSN-L)
- 2055-7124
- PMC
- PMC6862824
- OpenAlex
- W2989813791
- Cited by
- 80
- References
- 1
- Citations by year
- 2026: 13 · 2025: 5 · 2024: 13 · 2023: 20 · 2022: 11 · 2021: 10 · 2020: 7
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biomaterials Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Oceans and Fisheries, Korea (-)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- 3D bioprinting, natural biomaterials, tissue engineering, gelatin, hydroxyapatite, silk fibroin, pectin, acrylation, UV crosslinking, visible light crosslinking, riboflavin, collagen, decellularized extracellular matrix, printability, mechanical strength
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- The paper
- Choi, G., & Cha, H. J. (2019). Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering. Biomaterials Research. https://doi.org/10.1186/s40824-019-0168-8
