The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
RANKL biology: bone metabolism, the immune system, and beyond
Open accessAbstract
Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signaling receptor RANK, or decoy receptor osteoprotegerin (OPG) lead to bone diseases such as osteopetrosis, the RANKL/RANK/OPG system is essential for bone resorption. RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The essentiality of RANKL in the bone and the immune systems lies at the root of the field of “osteoimmunology.” Furthermore, this cytokine functions beyond the domains of bone metabolism and the immune system, e.g., mammary gland and hair follicle formation, body temperature regulation, muscle metabolism, and tumor development. In this review, we will summarize the current understanding of the functions of the RANKL/RANK/OPG system in biological processes.
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Cites
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Large-scale plasma proteomics comparisons through genetics and disease associations
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The Development of Molecular Biology of Osteoporosis
Gao, Y., Patil, S., & Jia, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158182 · Cited by 116
Role of the RANK/RANKL/OPG and Wnt/β-Catenin Systems in CKD Bone and Cardiovascular Disorders
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Cui, Y., Lv, B., Li, Z., Ma, C., Gui, Z., Geng, Y., Liu, G., Sang, L., Xu, C., Min, Q., et al. (2024) · Small · doi:10.1002/smll.202303494 · Cited by 81
Research progress on sarcopenia in the musculoskeletal system
Mao, X., Lv, K., Qi, W., Cheng, W., Li, T., Sun, Y., Jin, H., Pan, H., & Wang, D. (2025) · Bone Research · doi:10.1038/s41413-025-00455-8 · Cited by 37
Metadata
- Authors
- Ono, T., Hayashi, M., Sasaki, F., & Nakashima, T.
- Venue
- Inflammation and Regeneration
- Published
- 2020-02-07
- Volume
- 40
- Issue
- 1
- Pages
- 2-2
- ISSN
- 1346-8022 (ISSN-L)
- 1880-8190
- OpenAlex
- W3007176081
- Cited by
- 578
- References
- 113
- FWCI
- 17.84
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
