Cited by 245Wound Healing and TreatmentsPhytochemistry and biological activity of medicinal plantsMedicinal Plant Research

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Medicinal plants and their components for wound healing applications

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Sharma, Akshay, Khanna, Suryamani, Kaur, Gaganjot, Singh, Inderbir·2021·Future Journal of Pharmaceutical Sciences

Abstract

Background: Wound is an anatomical and functional disruption of the skin following an injury. In response to the injury, wound healing is a complex process of tissue repair or remodeling. Historically, plants and plant-based constituents have been extensively used for the treatment and management of different types of wounds. In the current times, different types of biopolymers are being researched for developing economical, sustainable, stable, and effective delivery system for the treatment of wounds. Main text: The present review article attempts to enlist medicinal plants which have been reported to be effective in the treatment of wounds. Plant constituent-based wound dressings have also been discussed systematically including patented formulations reported by different inventors. Conclusion: The compiled data aims to update the researchers/scientists which will be helpful in providing them a directional view in understanding the role and importance of plant-based components for the treatment and management of wounds.

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Crossref · 10.1186/s43094-021-00202-w

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Research works printed but not linked: 81

  1. Mukherjee K, Rajesh Kumar M (2003) Evaluation of wound healing activity of some herbal formulations Published online in Wiley. Inter Sci 117:265–268. https://doi.org/10.1002/ptr.93 · DOI
  2. Kirtikar KR, Basu BD (2001) Indian medicinal plants, Int Plants. Oriental Enterprises, Dehra Dun
  3. Budovsky A, Yarmolinsky L, Ben‐Shabat S (2015) Effect of medicinal plants on wound healing. Wound Repair Regen 23:171–183 · DOI
  4. Yuan H, Ma Q, Ye L, Piao G (2016) The traditional medicine and modern medicine from natural products. Mol 21(5):559 · DOI
  5. Schilling JA (1985) Wound healing. Psyrev 48(2):374–415
  6. Flanagan M (1996) Wound management New York. Churc Liv Inc 1:22–26
  7. Clark RA (2001) Fibrin and wound healing. Ann N Y Acad Sci 936:355–367 · DOI
  8. Lawrence WT, Diegelmann RF (1994) Growth factors in wound healing. Clin Derm 12(1):157–169 · DOI
  9. Ross R (1969) Wound healing. Sci Am 220(6):40–50 · DOI
  10. Prockop DJ, Kivirikko KI (1995) Collagens: molecular biology, diseases and potentials for therapy. Annu Rev Biochem 64:403–434 · DOI
  11. Schultz GS (1999) Molecular regulation of wound healing in: acute and chronic wounds: nur mngmt. Br, RA (Ed), 2nd edn, pp 413–429
  12. Nagori BP, Salonki R (2011) Role of medicinal in wound healing. Res J Med Plant 5(4):392–405 · DOI
  13. Chen J, MD KR (2007) Pathophysiology of acute wound healing. Clin Derm 25:9–18 · DOI
  14. Kirsner RS, Eaglstein WH (1993) The wound healing process. Clin Derm 11:629–640 · DOI
  15. Demidova-Rice TN (2012) Acute and impaired wound healing: pathophysiology and current methods for drug delivery. Part 1: Normal and Chronic Wounds: Biology Causes and Approaches to Care. Adv Skin Wound Care 25(7):304–314
  16. Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ (2002) Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 16:771–780 · DOI
  17. Jain S, Shrivastave S, Nayak S (2007) Recent trends in Curcuma longa Linn. Ph Cog Rev 1:119
  18. Ameri A, Rajive BB, Vaidya JG, Apte K, Deokule SS (2013) Anti-staphylococcal and wound healing activities of Ganoderma praelongum and Glycyrrhiza glabra formulation in mice. Int J Appl Res Natural Prod 6(1):27–31
  19. Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN (1999) In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol 65(1):1–11 · DOI · Paper page
  20. Chen YJ, Dai YS, Chen BF (1999) The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats. Biol Pharm Bull 22(7):703–706 · DOI
  21. Kumarasamyraja D, Jeganathan NS, Manavalan RA (2012) Review on medicinal plants with potential wound healing activity. J Pharm Sci 2(4):105–111
  22. Georgescu M, Chifiriuc CM, Marutesc L (2017) Bioactive wound dressings for the management of chronic wounds. Curr Org Chem 21:53–63 · DOI
  23. Yang CS, Chen G, Wu Q (2014) Recent scientific studies of a traditional Chinese medicine tea on prevention of chronic diseases. J Tradit Complement Med 4(1):17–23 · DOI
  24. Rani S, Amanjot G, Surya P, Kanwar K, Kaur S (2016) Wound healing potential of medicinal plants with their screening models: a comprehensive review. J Drug Deliv Ther 6(1):56–56
  25. Osunwokeemek O, Allison J, Theodore AO, Julius C (2013) The wound healing effects of aqueous leave extracts of Azadirachta indica on Wistar rats. Int J Nat Res 3:181–186
  26. Kiran K, Asad M (2008) Wound healing activity of Sesamum indicum L seed and oil in rats. Indian J Exp Biol 46(11):777–782
  27. Sapna S, Anju D, Sanju NS (2016) Traditional Indian medicinal plants with potential wound healing activity: a review. Int J Pharm Sci Res 7(5):1809–1819
  28. Himesh S, Singhai AK (2012) A recent update of botanical for wound healing activity. Res J Pharm 3(7):1–7
  29. Muhammad AA, Karthivashan G, Arulselvan P, Fakurazi S (2015) In vitro antioxidant properties of bioactive fraction of Moringa oleifera. J Natprod. Biomed Res 1(2):51–56
  30. Nayak BS, Isito GN, Maxwell A, Bhogadi V, Ramdath DD (2007) Wound healing activity of Morinda citrifolia fruit juice on diabetes induced rats. J Wound Care 16(2):83–86 · DOI
  31. Manjunatha K, Vidya V, Mankani S, Manohara Y (2007) Wound healing activity of Lycopodium serratum. Indian J Pharm Sci 69(2):283–287 · DOI
  32. Nayak BS, Pinto Pereira LM (2006) Catharanthus roseus flower extract has wound healing activity in Sprague Dawley rats. BMC Comp Alt Med 6(41):1–6
  33. Mittal A, Sardana S, Pandey A (2013) Herbal boon for wounds. Int J Pharm Sci 5(2):1–12
  34. Yogesh SG, Jeyabalan RSA (2013) Potential wound healing agents from medicinal plants: a review. Pharmacol 4(5):349–358
  35. Chaudhary G, Goya S, Poonia P (2010) Lawsonia inermis Linnaeus: a phytopharmacological review. Int J Pharm Sci Drug Res 2(2):91–98
  36. Asif A, Kakub G, Mehmood S, Khunum R, Gulfraz M (2007) Wound healing activity of root extracts of Berberis lyceum Royle in rats. Phytother Res 21(6):589–591 · DOI
  37. Galehdari H, Negahdari S, Kesmati M, Rezaie A, Shariati G (2016) Effect of the herbal mixture composed of Aloe vera Henna Adiantum capillus-veneris and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Comp Alt Med 16(1):386 · DOI
  38. Orue G, Gainza G, Gutierrez FB (2017) Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. Int J Pharma 523(2):556–566 · DOI
  39. Balekar N, Nakpheng T, Katkam NG, Srichana T (2012) Wound healing activity of ent-kaura-9(11)16-dien-19-oicacid isolated from Wedelia trilobata (L.) leaves. Phytomed 19(13):1178–1184 · DOI
  40. Govindappa M (2011) Antimicrobial, antioxidant and in vivo anti-inflammatory activity of ethanol extract and active phytochemical screening of Wedelia trilobata (L.) Hitchc. J Med Plants Res 5(24):5718–5729
  41. Vinothapooshan G, Sundar K (2010) Wound healing effect of various extracts of Adhatoda vasica. Int J Pharma Bio Sci 1(4):530–536
  42. Mahmood A, Salmah I (2005) Wound healing activity of Carica papaya L. aqueous leaf extract in rats. Int J Mol Med 1(4):398–401
  43. Selvaraj N, Lakshmanan B, Mazumder PM, Karuppasamy M, Jena SS, Pattnaik AK (2011) Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract. Asian Pac J Trop Med 4(12):959–963 · DOI
  44. Akilandeswari S, Senthamarai R, Valarmathi R, Prema S (2010) Wound healing activity of Sida acuta in rats. Int J Pharmtech Res 2(1):585–587
  45. Koca U, Süntar I, Akkol E, Yilmazer D, Alper M (2011) Wound repair potential of Olea europaea L. leaf extracts revealed by in vivo experimental models and comparative evaluation of the extracts’ antioxidant activity. J Med Food 14(1-2):140–146 · DOI
  46. Nair RV (1995) Indian medicinal plants- a compendium of 500 species. (Mentha arvensis Linn, Warrier PK, Nambiar VPK, Ramankutty C editors). Hyd: Ori Long Pvt Ltd 4:15–17
  47. Kishore B, Siva Prasad M, Murthy GK (2011) Comparison of the dermal wound healing of Centella asiatica extract impregnated collagen and crosslinked collagen scaffolds. J Chem Pharm Res 3(3):353–362
  48. Saraswathy N, Rohit R, Shanmugan K, Charanya S, Ramalingam P (2012) A preliminary investigation of turmeric-agar composite films as bioactive wound dressing material on excision wound on rat model. IJNPR 3(2):237–241
  49. Gopinath D, Rafiuddin A, Gomathi M, Chitra K, Sehgal PK, Jayakumar R (2004) Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 25(10):1911–1917 · DOI
  50. Jain SJ, Tiwari N, Balekar A, Jain DK (2009) Simple evaluation of wound healing activity of polyherbal formulation of roots of Ageratum conyzoides Linn. Asian J Res Chem 2(2):135–138
  51. Seongwon C, Myung-Hee C (2003) A review on the relationship between Aloe vera components and their biologic effects. Sem Int Med 1(1):53–62 · DOI
  52. Ahmad O, Aboutorab TN, Naeini T, Behrooz NE (2010) Effect of aqueous extract of aloe vera on experimental cutaneous wound healing in rat. Vet Arhiv 80(4):509–522
  53. Ramnath V, Sekar S, Sankar S, Sastry TP, Mandal AB (2012) In vivo evaluation of composite wound dressing material containing soya protein and sago starch. Int J Pharm Sci 4(2):414–419
  54. Xiong Y, Chen L, Man J, Hu Y, Cui X (2019) Chemical and bioactive comparison of Panax notoginseng root and rhizome in raw and steamed forms. J Gin Res 43(3):385–393 · DOI
  55. Lee J, Hwang H, Ko EJ (2014) Immunomodulatory activity of red ginseng against influenza A virus infection. Nutrients 6(2):517–529 · DOI
  56. Viji CS, Trikkurmadom SA, Rajalekshmi G, Pandimadevi M (2015) Preliminary in vitro study on the bovine collagen film incorporated with Azadirachta indica plant extract as a potential wound dressing material. Int J PharmTech Res 8(6):248–257
  57. Viji CS, Trikkurmadom SA, Rajalekshmi G, Pandimadevi M (2015) Collagen Azadirachta indica (neem) leaves extract hybrid film as a novel wound dressing: in vitro studies. Int J Pharm Sci Rev Res 32(2):193–199
  58. Behrooz M, Payam Z, Iraj R, Morvarid M, Abdolghaffari HA, Mohammad AZ (2013) Morphology drug release, antibacterial, cell proliferation and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(e-caprolactone)/polystyrene blends. J Biomed Mater Res Part B 102(5):977–987
  59. van Rijswijk L (2006) Ingredient-based wound dressing classification: a paradigm shift that is passe and in need of replacement. J Wound Care 15:11–14 · DOI
  60. Sharma A, Singh I, Puri V (2019) Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin. Bioimpacts 9(1):37–43
  61. Waring MJ, Parsons D (2001) Physico-chemical characterisation of carboxymethylated spun cellulose fibers. Biomaterials 22:903–912 · DOI
  62. Sharma A, Mittal A, Puri V, Singh I (2020) Curcumin-loaded, alginate-gelatin composite fibres for wound healing applications. 3 Biotech 10:464 · DOI
  63. Sharma A, Puri V, Kumar P, Singh I (2020) Biopolymeric, nanopatterned, fibrous carriers for wound healing applications. Curr Pharma Des 26(38):4894–4908(15) · DOI
  64. Hoffman AS (2002) Hydrogels for biomedical applications. Adv Drug Deliv Rev 43:3–12 · DOI · Paper page
  65. Kuo CK, Ma PX (2001) Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering Part 1. Structure gelation rate and mechanical properties. Biomaterials 22:511–521 · DOI
  66. Wang L, Shelton RM, Cooper PR, Lawson M, Triffitt JT, Barralet JE (2003) Evaluation of sodium alginate for bone marrow cell tissue engineering. Biomaterials 24:3475–3481 · DOI
  67. Whitaker MJ, Quirk RA, Howdle RA, Shakesheff KM (2001) Growth factor release from tissue engineering scaffolds. J Pharm Pharmacol 53:1427–1437 · DOI
  68. Storie H, Mooney DJ (2006) Sustained delivery of plasmid DNA from polymeric scaffolds for tissue engineering. Adv Drug Deliv Rev 58:500–514 · DOI
  69. Didem D (2020) Development of Hypericum perforatum oil incorporated antimicrobial and antioxidant chitosan cryogel as a wound dressing material. Int J Bio Macro 161:1581–1590 · DOI
  70. Esimone CO, Nworu CS (2008) Cutaneous wound healing activity of a herbal ointment containing the leaf extract of Jatropha curcas L. (Euphorbiaceae). Int J App Res Nat Prod 1(4):1–4
  71. Caskey PR (2010) Api-med Medical Honey Limited. Use of honey in dressings. US 7,714,183 B2 2010
  72. Akzo Nobel surface chemistry. Michael Koganov (2013) Bioactive compositions from thecae plants and processes for their production and use. US 2013/0146481 A1 2013
  73. Suresh Balkrishna Patankar (2013) Novel herbal composition for the treatment of wound healing a regenerative medicine. US 2013/0323337 A1 2013
  74. Walia, praveen, Walia, amita (2014) A multifunctional natural wound healing matrix. WO 2014/147638 Al 2014
  75. Patankar SB (2014) Herbal composition for the treatment of wound healing. A regenerative medicine. US 8,709,509 B2 2014
  76. Melikoglu, Ahmet (2015) EP 2 896 396 A1 2015
  77. Kerri-Anne carlene weller, Co. Mayo (2017). A topical herbal formulation. GB 2543091 A1 2017
  78. Sabacinski KA (2019) Buckwheat honey and bacitracin wound-healing dressing. WO 2019/078931 Al 2019
  79. Dinesh Upendra Nayak, Rabindranath AITHAL, Dakshin Kannada (2019) Herbal oil formulation for topical use and medicinal applications thereof. US 2019/0201474 A1 2019
  80. Mikolaj Tomulewicz (2019) Herbal preparation for accelerating wounds and skin inflammations healing and its application. US 10,213,469 B2 2019
  81. Omkar M (2020) Wakeri for wound healing. WO 2020/044368 A1 2020

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Metadata

Authors
Sharma, A., Khanna, S., Kaur, G., & Singh, I.
Affiliations
Chitkara University (IN)
Corresponding author
Singh, Inderbir
Venue
Future Journal of Pharmaceutical Sciences
Published
2021-02-25
Volume
7
Issue
1
ISSN
  • 2314-7245 (ISSN-L)
  • 2314-7253
OpenAlex
W3134517414
Cited by
245
References
2
Citations by year
2026: 25 · 2025: 44 · 2024: 62 · 2023: 61 · 2022: 45 · 2021: 7
FWCI
23.09
Type
journal article
Language
en
Open access
Locations
  • Future Journal of Pharmaceutical Sciences (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Chitkara University
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
medicinal plants, wound healing, biopolymers, drug delivery systems, tissue repair

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