The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bacterial exo-polysaccharides in biofilms: role in antimicrobial resistance and treatments
Open accessAbstract
BACKGROUND: Bacterial biofilms are aggregation or collection of different bacterial cells which are covered by self-produced extracellular matrix and are attached to a substratum. Generally, under stress or in unfavorable conditions, free planktonic bacteria transform themselves into bacterial biofilms and become sessile. MAIN BODY: Various mechanisms involving interaction between antimicrobial and biofilm matrix components, reduced growth rates, and genes conferring antibiotic resistance have been described to contribute to enhanced resistance. Quorum sensing and multi-drug resistance efflux pumps are known to regulate the internal environment within the biofilm as well as biofilm formation; they also protect cells from antibiotic attack or immune attacks. This review summarizes data supporting the importance of exopolysaccharides during biofilm formation and its role in antibiotic resistance. CONCLUSIONS: Involvement of quorum sensing and efflux pumps in antibiotic resistance in association with exopolysaccharides. Also, strategies to overcome or attack biofilms are provided.
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Azevedo, R. S. S., de Sousa, J. R., Araujo, M. T. F., Martins Filho, A. J., de Alcantara, B. N., Araujo, F. M. C., Queiroz, M. G. L., Cruz, A. C. R., Vasconcelos, B. H. B., Chiang, J. O., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-17765-5 · Cited by 3,478
A component of innate immunity prevents bacterial biofilm development
Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026
Spanò, A., Laganà, P., Visalli, G., Maugeri, T. L., & Gugliandolo, C. (2016) · Current Microbiology · doi:10.1007/s00284-015-0981-9 · Cited by 92
Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Zeineldin, M., Esmael, A., Al-Hindi, R. R., Alharbi, M. G., Ashenafi Bekele, D., & Teklemariam, A. D. (2023) · Life · doi:10.3390/life13020503 · Cited by 27
Mafe, A. N., & Büsselberg, D. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070820 · Cited by 18
Metadata
- Authors
- Singh, S., Datta, S., Narayanan, K. B., & Rajnish, K. N.
- Venue
- Journal of Genetic Engineering and Biotechnology
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 19
- Issue
- 1
- Pages
- 140
- ISSN
- 1687-157X (ISSN-L)
- OpenAlex
- W3199491662
- Cited by
- 331
- References
- 3
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- Singh, S., Datta, S., Narayanan, K. B., & Rajnish, K. N. (2021). Bacterial exo-polysaccharides in biofilms: role in antimicrobial resistance and treatments. Journal of Genetic Engineering and Biotechnology. https://doi.org/10.1186/s43141-021-00242-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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