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Cited by 125Zebrafish Biomedical Research ApplicationsErythropoietin and Anemia TreatmentHematopoietic Stem Cell Transplantation

Zebrafish erythropoiesis and the utility of fish as models of anemia

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Kulkeaw, Kasem, Sugiyama, Daisuke·2012·Stem Cell Research & Therapy
DOI 10.1186/scrt146PMC PMC3580485
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Abstract

Erythrocytes contain oxygen-carrying hemoglobin to all body cells. Impairments in the generation of erythrocytes, a process known as erythropoiesis, or in hemoglobin synthesis alter cell function because of decreased oxygen supply and lead to anemic diseases. Thus, understanding how erythropoiesis is regulated during embryogenesis and adulthood is important to develop novel therapies for anemia. The zebrafish, Danio rerio, provides a powerful model for such study. Their small size and the ability to generate a large number of embryos enable large-scale analysis, and their transparency facilitates the visualization of erythroid cell migration. Importantly, the high conservation of hematopoietic genes among vertebrates and the ability to successfully transplant hematopoietic cells into fish have enabled the establishment of models of human anemic diseases in fish. In this review, we summarize the current progress in our understanding of erythropoiesis on the basis of zebrafish studies and highlight fish models of human anemias. These analyses could enable the discovery of novel drugs as future therapies.

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  • The primitive wave initiates the generation of blood cells to supply oxygen and establish the immune system.

    “The primitive wave initiates the generation of blood cells to supply oxygen and establish the immune system (Davidson & Zon, 2004; Kulkeaw & Sugiyama, 2012).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Kulkeaw & Sugiyama, 2012

    Section 1 says the primitive wave generates erythrocytes and macrophages, and the Introduction explains that erythrocytes supply oxygen. The paper does not attribute establishment of the immune system as a whole to the primitive wave: Section 1 assigns production of lymphocytes and other blood cell types to the definitive wave. (LLM, conf=0.84)

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Cited by

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Authors
Kulkeaw, K., & Sugiyama, D.
Affiliations
Kyushu University (JP)
Corresponding author
Sugiyama, Daisuke
ORCID
Venue
Stem Cell Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2012-12
Volume
3
Issue
6
Pages
55-55
ISSN
1757-6512 (ISSN-L)
DOI
10.1186/scrt146
PMC
PMC3580485
OpenAlex
W2123181690
Cited by
125
References
4
Citations by year
2026: 2 · 2025: 15 · 2024: 17 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 2 · 2013: 1
FWCI
0.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cell Research & Therapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Tokyo Biochemical Research Foundation
  • Japan Society for the Promotion of Science (24659464)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
erythropoiesis, zebrafish, anemia, erythrocytes, hemoglobin synthesis, hematopoietic stem cell transplantation, disease models, embryonic development, drug discovery
MeSH terms
Anemia, Anemia, Dyserythropoietic, Congenital, Anemia, Hypochromic, Anemia, Sideroblastic, Animals, Disease Models, Animal, Erythrocytes, Erythropoiesis, Hemochromatosis, Spherocytosis, Hereditary, Zebrafish, Ankyrins, Cation Transport Proteins, Genetic Diseases, X-Linked

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