Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease

Ito, Shunsuke; Higuchi, Yusuke; Yagi, Yoko; Nishijima, Fuyuhiko; Yamato, Hideyuki; Ishii, Hideto; Osaka, Mizuko; Yoshida, Masayuki

doi:10.1189/jlb.0112023

Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease

Indoxyl sulfate induced Mac-1 expression and ROS production via p38 MAPK- and NAD(P)H oxidase-dependent pathways. Accelerated cardiovascular disease is a frequent complication of CKD. Monocyte-mediated inflammation and adhesion of monocytes to vascular endothelium are key events in atherogenesis.…