The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
NF-κB Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91
Open accessAbstract
The superoxide-generating phagocytic NADPH oxidase is an important component of the innate immune response against microbial agents, and is involved in shaping the cellular response to a variety of physiological and pathological signals. One of the downstream targets of NADPH oxidase-derived radicals is the ubiquitous transcription factor NF-kappaB, which controls the expression of a large array of genes involved in immune function and cell survival. Here we show that NF-kappaB itself is a key factor in controlling NADPH oxidase expression and function. In monocytic and microglial cell lines, the expression of the NADPH oxidase subunit gp91(phox) was induced by lipopolysaccharide/interferon gamma treatment and was inhibited in cells constitutively expressing IkappaBalpha. Furthermore, inducible reactive oxygen species production was inhibited in IkappaBalpha overexpressing cells. gp91(phox) expression was very low in RelA(-/-) fibroblasts and could be induced by reconstituting these cells with p65/RelA. Thus, gp91(phox) expression is dependent on the presence of p65/RelA. We also found that gp91(phox) transcription is dependent on NF-kappaB and we identified two potential cis-acting elements in the murine gp91(phox) promoter that control NF-kappaB-dependent regulation. The findings raise the possibility of a positive feedback loop in which NF-kappaB activation by oxidative stress leads to further radical production via NADPH oxidase.
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Cited by
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Crosstalk of reactive oxygen species and NF-κB signaling
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Reactive Oxygen Species in Metabolic and Inflammatory Signaling
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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
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Metadata
- Authors
- Anrather, J., Racchumi, G., & Iadecola, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 281
- Issue
- 9
- Pages
- 5657-5667
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1987880652
- Cited by
- 386
- References
- 60
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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