Cited by 183Immune cells in cancerImmunotherapy and Immune ResponsesPhagocytosis and Immune Regulation

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Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages

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Stout, Robert D, Watkins, Stephanie K, Suttles, Jill·2009·Journal of Leukocyte Biology

DOI 10.1189/jlb.0209073PMC PMC2774875

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Abstract

Functionally polarized macrophages in chronic pathologies are highly adaptable cells displaying a functional response to tissue signals, which response can be reprogrammed to therapeutic advantage. The extent to which the functional heterogeneity of Mφs is dependent on the differentiation of functional sublineages remains unresolved. One alternative hypothesis proposes that Mφs are functionally plastic cells, which are capable of altering their functional activities progressively in response to progressively changing signaling molecules generated in their microenvironment. This “functional plasticity” hypothesis predicts that the functionally polarized Mφs in chronic pathologies do not represent Mφ sublineages but rather, are mutable phenotypes sustained by chronic signaling from the pathological environment. Solid TAMφs are chronically polarized to provide activities that support tumor growth and metastasis and suppress adaptive immune responses. In support of the functional plasticity hypothesis, administration of slow-release microsphere-encapsulated IL-12 successfully reprogrammed TAMφs in situ, reducing Mφ support of tumor growth and metastasis and enhancing Mφ proimmunogenic activities. Increased knowledge of how Mφ function is regulated and how polarized Mφs can be reprogrammed in situ will increase our ability to control Mφ function in a variety of pathological states, including cancer and chronic inflammatory disease.

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Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Cutaneous Wound Healing
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
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Rosenberg, S. A., Yang, J. C.-H., & Restifo, N. P. (2004) · Nature Medicine · doi:10.1038/nm1100 · Cited by 2,980
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Interleukin 12: A Proinflammatory Cytokine with Immunoregulatory Functions That Bridge Innate Resistance and Antisen-Specific Adaptive Immunity
Trinchieri, G. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.001343 · Cited by 2,379
Distinct role of macrophages in different tumor microenvironments
Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225
Wound healing: an overview of acute, fibrotic and delayed healing
Diegelmann, R. (2004) · Frontiers in Bioscience · doi:10.2741/1184 · Cited by 2,147

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Stout, 1995, T cell signaling of macrophage activation
Adams, 1992, Molecular basis of macrophage activation: diversity and its origins, 75

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References
Alexander, M. A. (2011) · Science Publishers eBooks · doi:10.1201/b10503-18
Dynamics of Cobalt Oxide Nanoparticles in the Activation of Reactive Oxygen Species-Induced Inflammation and Immunomodulation
Chattopadhyay, S., & Roy, S. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_178
ENDOGENOUS GLUCOCORTICOID SIGNALING IS REQUIRED FOR NORMAL MACROPHAGE RESPONSE TO H. pylori INFECTION
Khadka, S. (2024) · doi:10.33915/etd.12613
Mesangiogenic progenitor cells: a mesengenic and vasculogenic branch of hemopoiesis? A story of neglected plasticity
Pacini, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1513440
AMP-activated protein kinase regulation of myeloid antigen presenting cell activity.
Carroll, K. (2013) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/215
Importance des glycosaminoglycanes de surface dans les phénomènes inflammatoires liés au cancer
Martinez, P. (2014) · theses.fr (ABES) · doi:10.70675/d8d46778ze3baz4df0z9270z4a2656f165d0
Caractérisation phénotypique et fonctionnelle des différentes sous-populations cellulaires du tissu conjonctif musculaire
Brigitte, M. (2010) · theses.fr (ABES) · doi:10.70675/9d3da2bfz02c5z4f8bzb4b0zd7c5f95ca3ba

Authors: Stout, R. D., Watkins, S. K., & Suttles, J.
Affiliations: University of Louisville (US)
Frederick National Laboratory for Cancer Research (US)
Corresponding author: Stout, Robert D
ORCID: Watkins, Stephanie K
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2009-07-15
Volume: 86
Issue: 5
Pages: 1105-1109
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0209073
PMC: PMC2774875
OpenAlex: W2128057905
Cited by: 183
References: 65
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 9 · 2017: 13 · 2016: 6 · 2015: 18 · 2014: 21 · 2013: 23 · 2012: 19
FWCI: 1.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AI048850)
Kentucky Lung Cancer Research Fund
The American Lung Association
Commonwealth of Kentucky Research Challenge Trust Fund
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: tumor-associated macrophages, macrophage reprogramming, macrophage polarization, IL-12, tumor growth, metastasis, immunosuppression, chronic inflammation, cancer immunotherapy
MeSH terms: Cell Differentiation, Humans, Immune System, Killer Cells, Natural, Macrophages, Monocytes, Neoplasms, Th1 Cells, Th2 Cells

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Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages

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