Cited by 2,225Immune cells in cancerAngiogenesis and VEGF in CancerCancer Cells and Metastasis

Distinct role of macrophages in different tumor microenvironments

Lewis, Claire E., Pollard, Jeffrey W.·2006·Cancer Research

Abstract

Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility, stromal and perivascular areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stimulate angiogenesis. This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes. (Cancer Res 2006; 66(2): 605-12)

Integrity signals

Registry

Crossref · 10.1158/0008-5472.can-05-4005

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81 of 81 references verified0 citation errors · 0 not checkable

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  • Most tumour-associated macrophages (TAM) adopt an M2-type phenotype, and their presence correlates with poor prognosis.

    “Most tumour-associated macrophages (TAM) adopt an M2-type phenotype, and their presence correlates with a poor prognosis [199,200].”
  • In cancer, M1 macrophages have anti-tumour functions, while M2 macrophages support angiogenesis, invasion and metastasis of neoplastic cells.

    “In cancer, M1 macrophages have anti-tumour functions, while M2 macrophages support angiogenesis, invasion and metastasis of neoplastic cells.”

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Authors
Lewis, C. E., & Pollard, J. W.
Affiliations
  • University of Sheffield (GB)
  • Albert Einstein College of Medicine (US)
Venue
Cancer Research
Published
2006-01-15
Volume
66
Issue
2
Pages
605-612
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W2131464730
Cited by
2,225
References
81
Citations by year
2026: 24 · 2025: 59 · 2024: 88 · 2023: 112 · 2022: 102 · 2021: 121 · 2020: 147 · 2019: 105 · 2018: 112 · 2017: 117 · 2016: 122 · 2015: 115 · 2014: 152 · 2013: 143 · 2012: 123
FWCI
7.67
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA 94173, P01CA100324, R01CA094173, CA 100324, P30CA013330)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
tumor-associated macrophages, tumor microenvironment, tumor stroma, tumor invasion, metastasis, angiogenesis, hypoxia, cytokines and chemokines, TAM-targeted therapy
MeSH terms
Cell Movement, Humans, Immunotherapy, Macrophages, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Disease Progression

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