The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection
Open accessAbstract
Previous studies have shown that some respiratory virus infections leave local populations of tissue TRM cells in the lungs which disappear as heterosubtypic immunity declines. The location of these TRM cells and their contribution to the protective CTL response have not been clearly defined. Here, fluorescence microscopy is used to show that some CD103+ TRM cells remain embedded in the walls of the large airways long after pulmonary immunization but are absent from systemically primed mice. Viral clearance from the lungs of the locally immunized mice precedes the development of a robust Teff response in the lungs. Whereas large numbers of virus-specific CTLs collect around the bronchial tree during viral clearance, there is little involvement of the remaining lung tissue. Much larger numbers of TEM cells enter the lungs of the systemically immunized animals but do not prevent extensive viral replication or damage to the alveoli. Together, these experiments show that virus-specific antibodies and TRM cells are both required for optimal heterosubtypic immunity, whereas circulating memory CD8 T cells do not substantially alter the course of disease.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“Two major populations of virus-specific memory CD8 T cells remain in the circulation after viral clearance [7, 8].”
BackgroundPreferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 1×
“Two major populations of virus-specific memory CD8 T cells remain in the circulation after viral clearance [7, 8].”
BackgroundPerrone, L. A., Ahmad, A., Veguilla, V., Lu, X., Smith, G., Katz, J. M., Pushko, P., & Tumpey, T. M. (2009) · Journal of Virology · doi:10.1128/jvi.00207-09 · Cited by 143 · cited 1×
“Cell-mediated immunity lasts 4–6 months after pulmonary influenza virus infection [3] and cannot be induced effectively by other routes of inoculation [4, 28].”
BackgroundMutnal, M. B., Hu, S., Little, M. R., & Lokensgard, J. R. (2011) · Journal of NeuroVirology · doi:10.1007/s13365-011-0042-5 · Cited by 51
Cited by
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“Indeed, CD8+ and CD4+ T cell memory in the lung and lung airways wanes within months after influenza infection, leading to the loss of protective heterosubtypic immunity (Hogan et al., 2001; Liang et al., 1994; Wu et al., 2014).”
BackgroundTissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
Resident memory CD8 T cells trigger protective innate and adaptive immune responses
Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. (2014) · Science · doi:10.1126/science.1254536 · Cited by 731
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance
Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685
The multifaceted role of CD4+ T cells in CD8+ T cell memory
Laidlaw, B. J., Craft, J. E., & Kaech, S. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.10 · Cited by 657
Metadata
- Authors
- Wu, T., Hu, Y., Lee, Y.-T., Bouchard, K. R., Benechet, A., Khanna, K., & Cauley, L. S.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09-04
- Volume
- 95
- Issue
- 2
- Pages
- 215-224
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W1988511365
- Cited by
- 530
- References
- 4
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, T., Hu, Y., Lee, Y.-T., Bouchard, K. R., Benechet, A., Khanna, K., & Cauley, L. S. (2013). Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0313180
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
