The many faces of macrophage activation

NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287

Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation

Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957

Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism

Hesse, M., Modolell, M., Flamme, A. C. L., Schito, M. L., Fuentes, J. M., Cheever, A. W., Pearce, E. J., & Wynn, T. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6533 · Cited by 723

Other Functions, Other Genes

Goerdt, S., & Orfanos, C. E. (1999) · Immunity · doi:10.1016/s1074-7613(00)80014-x · Cited by 678

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

Modolell, M., Corraliza, I. M., Link, F., Soler, G., & Eichmann, K. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250436 · Cited by 554

Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

Ehrt, S., Schnappinger, D., Bekiranov, S., Drenkow, J., Shi, S., Gingeras, T., Gaasterland, T., Schoolnik, G. K., & Nathan, C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1123 · Cited by 467

Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts

Song, E., Ouyang, N., Hörbelt, M., Antus, B., Wang, M., & Exton, M. S. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1687 · Cited by 447

Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages

Raes, G., BAETSELIER, P. D., Noël, W., Beschin, A., Brombacher, F., & Gh., G. H. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.597 · Cited by 443

Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

Sutterwala, F. S., Noel, G. J., Clynes, R., & Mosser, D. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.11.1977 · Cited by 348

A novel phenotype for an activated macrophage: the type 2 activated macrophage

Anderson, C. F., & Mosser, D. M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.101 · Cited by 347

Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production

Rutschman, R., Lang, R., Hesse, M., Ihle, J. N., Wynn, T. A., & Murray, P. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2173 · Cited by 331

Mycobacterium tuberculosis Inhibits IFN-γ Transcriptional Responses Without Inhibiting Activation of STAT1

Ting, L.-M., Kim, A. C., Cattamanchi, A., & Ernst, J. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3898 · Cited by 328

Reversal of Proinflammatory Responses by Ligating the Macrophage Fcγ Receptor Type I

Sutterwala, F. S., Noel, G. J., Salgame, P. R., & Mosser, D. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.217 · Cited by 327

Alternative versus Classical Activation of Macrophages

Goerdt, S., Politz, O., Schledzewski, K., Birk, R., Gratchev, A. N., Guillot, P., Hakiy, N., Klemke, C., Dippel, E., Kodelja, V., et al. (1999) · Pathobiology · doi:10.1159/000028096 · Cited by 324

Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.

Ting, L. M., Kim, A. C., Cattamanchi, A., & Ernst, J. D. (1999) · PubMed · Cited by 315

Alternatively Activated Macrophages Differentially Express Fibronectin and Its Splice Variants and the Extracellular Matrix Protein βIG‐H3

Gratchev, A., Guillot, P., Hakiy, N., Politz, O., Orfanos, C. E., Schledzewski, K., & Goerdt, S. (2001) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2001.00885.x · Cited by 300

Reversing Lipopolysaccharide Toxicity by Ligating the Macrophage Fcγ Receptors

Gerber, J. S., & Mosser, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6861 · Cited by 263

Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern.

Kodelja, V., Müller, C., Politz, O., Hakij, N., Orfanos, C. E., & Goerdt, S. (1998) · PubMed · Cited by 249

Alternative Macrophage Activation-Associated CC-Chemokine-1, a Novel Structural Homologue of Macrophage Inflammatory Protein-1α with a Th2-Associated Expression Pattern

Kodelja, V., Müller, C., Politz, O., Hakij, N., Orfanos, C. E., & Goerdt, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.3.1411 · Cited by 223

Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fcγ Receptors1

Anderson, C. F., & Mosser, D. (2002) · Journal of Immunology · doi:10.4049/jimmunol.168.8.3697 · Cited by 187

Interferon‐lnduced Indoleamine 2,3‐Dioxygenase Activity in Human Mononuclear Phagocytes

Carlin, J. M., Borden, E. C., Sondel, P., & Byrne, G. I. (1989) · Journal of Leukocyte Biology · doi:10.1002/jlb.45.1.29 · Cited by 144

TGF-β in infections and infectious diseases

Reed, S. G. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)00252-x · Cited by 127

Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro

Schebesch, C., Kodelja, V., Müller, C., Hakij, N., Bisson, S., Orfanos, C. E., & Goerdt, S. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00371.x · Cited by 121

Interleukin-10 and its receptor.

Ho, A. S., & Moore, K. W. (1994) · PubMed · Cited by 100

Interleukin-3 and its receptor

Lindemann, A., & Mertelsmann, R. (1995) · Cancer treatment and research · doi:10.1007/978-1-4613-1241-3_5 · Cited by 91

Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport

Gruenheid, S. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00049-1 · Cited by 87

Activation of the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase by Macrophage-Stimulating Protein Results in the Induction of Arginase Activity in Murine Peritoneal Macrophages

Morrison, A. C., & Correll, P. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.853 · Cited by 68

Infection and Nitric Oxide

Hibbs, J. B. (2002) · The Journal of Infectious Diseases · doi:10.1086/338005 · Cited by 68

Association of lung carcinoma and tuberculosis.

Dacosta, N., & Kinare, S. G. (1991) · PubMed · Cited by 64

Alterations of Surface Properties by Macrophage Activation: Expression of Receptors for Fc and Mannose-Terminal Glycoproteins and Differentiation Antigens

Alan, R., Ezekowitz, B., & Gordon, S. (1984) · Springer eBooks · doi:10.1007/978-1-4757-1445-6_2 · Cited by 62

Mechanisms and modulation of macrophage activation.

Nathan, C. (1991) · PubMed · Cited by 61

Exploitation of host cell signaling machinery: activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis

Nandan, D., Knutson, K. L., Lo, R., & Reiner, N. E. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.4.464 · Cited by 46

Treatment of murine macrophages with interferon-γ inhibits their ability to bind leishmania promastigotes

Mosser, D. M., & Handman, E. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.52.4.369 · Cited by 45

The Relationship of Inflammation and Initiation of Autoimmune Disease: Role of TNF Super Family Members

Flavell, R. A. (2002) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-04700-2_1 · Cited by 35

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144

NF-κB signaling in inflammation

Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Monocyte and macrophage heterogeneity

Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190

Foreign body reaction to biomaterials

Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138

Alternative activation of macrophages: immune function and cellular biology

Varin, A., & Gordon, S. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.009 · Cited by 361

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

Dyken, S. J. V., & Locksley, R. M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095906 · Cited by 743

Receptor Is Associated with Alternative Macrophage Activation

Hamann, J. (2015)

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

The Alternatively Activated Human—Redux

Scott, A. L. (2009) · The Journal of Infectious Diseases · doi:10.1086/599091 · Cited by 2