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Cited by 113Estrogen and related hormone effectsCell Adhesion Molecules ResearchNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 61 of the 62 references it cites were found in a registry or an index.

Mechanisms of glucocorticoid-induced down-regulation of neutrophil L-selectin in cattle: evidence for effects at the gene-expression level and primarily on blood neutrophils

Weber, Patty S D, Toelboell, Trine, Chang, Ling-Chu, Tirrell, Janelle Durrett, Saama, Peter M, Smith, George W, Burton, Jeanne L·2004·Journal of Leukocyte Biology
DOI 10.1189/jlb.1003505
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Abstract

One anti-inflammatory action of glucocorticoids is down-regulation of surface L-selectin on circulating neutrophils. However, it is unclear if this is a result of release of affected bone marrow neutrophils or if the steroid has direct effects on L-selectin expression in existing blood neutrophils. We recently demonstrated that circulating neutrophils from cattle with high blood concentrations of endogenous glucocorticoid had reduced L-selectin mRNA, suggesting that the steroid interrupted L-selectin gene expression. In the current study, dexamethasone (DEX) was administered to cattle in vivo, and blood and bone marrow neutrophils were studied simultaneously within the animal to determine which pool of cells responds to glucocorticoids with inhibited L-selectin expression. Purified blood neutrophils were also treated with DEX ± RU486 in vitro, and glucocorticoid effects on L-selectin expression were determined. Our results indicate that glucocorticoid-induced suppression of L-selectin, which accompanies neutrophilia, is likely mediated by direct effects of glucocorticoid receptor activation on intracellular reservoirs of L-selectin mRNA and protein in cattle, predominantly in blood neutrophils.

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Metadata

Authors
Weber, P. S. D., Toelboell, T., Chang, L.-C., Tirrell, J. D., Saama, P. M., Smith, G. W., & Burton, J. L.
Affiliations
  • Immunogenetics Laboratory , East Lansing
  • Michigan State University (US)
Corresponding author
Burton, Jeanne L
ORCID
Chang, Ling-Chu
Venue
Journal of Leukocyte Biology
Publisher
Oxford University Press (OUP)
Published
2004-02-03
Volume
75
Issue
5
Pages
815-827
ISSN
  • 0741-5400 (ISSN-L)
  • 1938-3673
DOI
10.1189/jlb.1003505
OpenAlex
W2162667045
Cited by
113
References
62
Citations by year
2025: 1 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 15 · 2019: 4 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 8
FWCI
3.56
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • Journal of Leukocyte Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • USDA-NRI (#01-35204-10798)
  • Michigan Agricultural Experiment Station (#MICL 01836)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
glucocorticoids, L-selectin, neutrophils, cattle, dexamethasone, glucocorticoid receptor, gene expression regulation, neutrophilia, bone marrow neutrophils, anti-inflammatory activity, RU486, mRNA expression
MeSH terms
Animals, Blood Cells, Cattle, Dexamethasone, Glucocorticoids, Neutrophils, Receptors, Glucocorticoid, RNA, Messenger, Transcription, Genetic, Down-Regulation, L-Selectin

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