The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Aging and innate immune cells
Abstract
The innate immune system serves an important role in preventing microbial invasion. However, it experiences significant changes with advancing age. Among the age-associated changes are: Aged macrophages and neutrophils have impaired respiratory burst and reactive nitrogen intermediates as a result of altered intracellular signaling, rendering them less able to destroy bacteria. Aged neutrophils are also less able to respond to rescue from apoptosis. Aged dendritic cells (DC) are less able to stimulate T and B cells. The altered T cell stimulation is a result of changes in human leukocyte antigen expression and cytokine production, and lower B cell stimulation is a result of changes in DC immune complex binding. Natural killer (NK) cells from the elderly are less capable of destroying tumor cells. NK T cells increase in number and have greater interleukin-4 production with age. Levels of various complement components are also altered with advancing age.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Jemal, A., Murray, T., Samuels, A., Ghafoor, A., Ward, E., & Thun, M. J. (2003) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.53.1.5 · Cited by 3,275
Moore, K. (1993) · Annual Review of Immunology · doi:10.1146/annurev.immunol.11.1.165 · Cited by 1,884
(2002) · PsycEXTRA Dataset · doi:10.1037/e548512006-001 · Cited by 1,708
Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
Colotta, F., Re, F., Polentarutti, N., Sozzani, S., & Mantovani, A. (1992) · Blood · doi:10.1182/blood.v80.8.2012.2012 · Cited by 1,158
Nutrition and the immune system: an introduction
Chandra, R. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.460s · Cited by 888
Edwards, B. K., Howe, H. L., Ries, L. A. G., Thun, M. J., Rosenberg, H. M., Yancik, R., Wingo, P. A., Jemal, A., & Feigal, E. G. (2002) · Cancer · doi:10.1002/cncr.10593 · Cited by 880
Admission criteria for immunogerontological studies in man: The senieur protocol
Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90152-0 · Cited by 754 · cited 1×
“The SENIEUR protocol, which designates young as 25–34 years old and aged as 65 and above, is not exclusively used as a result of its limitations [8].”
BackgroundLee, A., Whyte, M. K. B., & Haslett, C. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.4.283 · Cited by 714
Cutting edge: impaired toll-like receptor expression and function in aging
Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4697 · Cited by 626
Research works printed but not linked: 16
- Pascual, 2003, Tetanus surveillance–United States, 1998–2000, MMWR Surveill. Summ., 52, 1
- Damtew, 1990, Neutrophil adhesion in the elderly: inhibitory effects of plasma from elderly patients, Clin. Immunol. Immunopathol., 54, 247, 10.1016/0090-1229(90)90086-6 · doi:10.1016/0090-1229(90)90086-6
- Tortorella, 1996, Lipopolysaccharide-, granulocyte-monocyte colony stimulating factor- and pentoxifylline-mediated effects on formyl-methionyl-leucine-phenylalanine-stimuated neutrophil respiratory burst in the elderly, Microbios, 85, 189
- Fulop, 1997, Effect of lithium on superoxide production and intracellular free calcium mobilization in elastin peptide (κ-elastin) and FMLP stimulated human PMNs. Effect of age, Life Sci., 60, 325, 10.1016/S0024-3205(97)00169-0 · doi:10.1016/s0024-3205(97)00169-0
- Rao, 1986, Age-related decline in ligand-induced actin polymerization in human leukocytes and platelets, J. Gerontol., 41, 561, 10.1093/geronj/41.5.561 · doi:10.1093/geronj/41.5.561
- Granucci, 2003, The immune response is initiated by dendritic cells via interaction with microorganisms and interleukin-2 production, J. Infect. Dis., 187, S346, 10.1086/374748 · doi:10.1086/374748
- Cai, 1990, The expression of granulocyte/macrophage colony-stimulating factor in activated mouse lymphocytes declines with age, Cell. Immunol., 130, 311, 10.1016/0008-8749(90)90274-U · doi:10.1016/0008-8749(90)90274-u
- Johnston, 1988, The respiratory burst in activated macrophages: studies of its molecular basis and evidence for downregulation in chronic infection, Adv. Exp. Med. Biol., 239, 63, 10.1007/978-1-4757-5421-6_7 · doi:10.1007/978-1-4757-5421-6_7
- Kumar, 2002, NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of visceral leishmaniasis patients, J. Med. Microbiol., 51, 832, 10.1099/0022-1317-51-10-832 · doi:10.1099/0022-1317-51-10-832
- Lu, 1999, Chronic exercise increases macrophage-mediated tumor cytolysis in young and aged mice, Am. J. Physiol., 276, R482
- Hsueh, 1996, Involvement of cytokine gene expression in the age-dependent decline of NK cell response, Cell. Immunol., 173, 221, 10.1006/cimm.1996.0271 · doi:10.1006/cimm.1996.0271
- Albright, 1998, Impaired natural killer cell function as a consequence of aging, Exp. Gerontol., 33, 13, 10.1016/S0531-5565(97)00099-5 · doi:10.1016/s0531-5565(97)00099-5
- Faunce, 2003, A role for CD1d-restricted NKT cells in injury-associated T cell suppression, J. Leukoc. Biol., 73, 747, 10.1189/jlb.1102540 · doi:10.1189/jlb.1102540
- Menzel, 1988, Autoimmunity and T-cell subpopulations in old age, Arch. Gerontol. Geriatr., 7, 249, 10.1016/0167-4943(88)90008-8 · doi:10.1016/0167-4943(88)90008-8
- Esparza-Gordillo, 2003, Genetic determinants of variation in the plasma levels of the C4-binding protein (C4BP) in Spanish families, Immunogenetics, 54, 862, 10.1007/s00251-003-0537-1 · doi:10.1007/s00251-003-0537-1
- Lavery, 2002, Decline in the expression of C4 binding protein α-chain gene during ageing of the rat liver, Biogerontology, 3, 207, 10.1023/A:1016251929165 · DOI
Cited by
Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968
Immunosenescence: emerging challenges for an ageing population
Aw, D., Silva, A. B., & Palmer, D. B. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02555.x · Cited by 880
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Pergolizzi, J., Böger, R. H., Budd, K., Dahan, A., Erdine, S., Hans, G., Kress, H., Langford, R., Likar, R., Raffa, R. B., et al. (2008) · Pain Practice · doi:10.1111/j.1533-2500.2008.00204.x · Cited by 854
Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567
Metadata
- Authors
- Plackett, T. P., Boehmer, E. D., Faunce, D. E., & Kovacs, E. J.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-23
- Volume
- 76
- Issue
- 2
- Pages
- 291-299
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2045836911
- Cited by
- 351
- References
- 132
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Funders
- NIH (R01 AG18859)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Aging and innate immune cells. https://app.cochat.ai/papers/10.1189/jlb.1103592
- The paper
- Plackett, T. P., Boehmer, E. D., Faunce, D. E., & Kovacs, E. J. (2004). Aging and innate immune cells. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.1103592
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
