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A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs
Open accessAbstract
Inflammation can directly and indirectly modulate the bacterial composition of the microbiome. Although studies of inflammation primarily focus on its function to negatively select against potential pathogens, some bacterial species have the ability to exploit inflammatory byproducts for their benefit. Inflammatory cells release reactive nitrogen species as antimicrobial effectors against infection, but some facultative anaerobes can also utilize the increase in extracellular nitrate in their environment for anaerobic respiration and growth. This phenomenon has been studied in the gastrointestinal tract, where blooms of facultative anaerobic Gammaproteobacteria, primarily Escherichia coli, often occur during colonic inflammation. In cystic fibrosis, Pseudomonas aeruginosa, another Gammaproteobacteria facultative anaerobe, can reduce nitrogen for anaerobic respiration and it blooms in the airways of the chronically inflamed cystic fibrosis lung. This review focuses on the evidence that inflammation can provide terminal electron acceptors for anaerobic respiration and can support blooms of facultative anaerobes, such as E. coli and P. aeruginosa in distinct, but similar, environments of the inflamed gastrointestinal and respiratory tracts.
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“Elevated rates of generation of these oxidative inflammatory mediators can have direct effects on enterocytes and mucosal integrity, impair NO-dependent vascular function, reduce nitrate and nitrite absorption, and exert selective pressure on bacteria by augmenting innate anti-bacterial effects[204,233,321–324].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [323]
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“Presumably, in the setting of inflammation, excess nitrite and nitrate are formed along with reactive oxygen radicals and nitrogen oxides through NO oxidation, thereby increasing the amount of substrate available for respiratory denitrification and rapid bacterial growth[323,337].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [323]
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“suggesting that bacterial nitrate metabolism in the gut is an important selective factor in pathogenic bacterial survival,”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [323]
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“In addition to LPS induction of TLR4, bacteria can also induce an immune response through a TLR9 interaction with unmethylated CpG motifs [71].”
BackgroundWebb, A. K. (2006) · Cited by 4,369
Update on Key Emerging Challenges in Cystic Fibrosis
Jennings, M. T., Riekert, K. A., & Boyle, M. (2014) · Medical Principles and Practice · doi:10.1159/000357646 · Cited by 3,671
Gut biogeography of the bacterial microbiota
Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676
Lung Infections Associated with Cystic Fibrosis
Lyczak, J. B., Cannon, C. L., & Pier, G. B. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.194-222.2002 · Cited by 1,655
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310
Early Pulmonary Inflammation in Infants with Cystic Fibrosis
Khan, T. Z., Wagener, J. S., Bost, T., Martínez, J. A. B., Accurso, F. J., & Riches, D. W. H. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.4.1075 · Cited by 1,264
Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U. E., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiß, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13870 · Cited by 1,151
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048
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Sorted by citations
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Huffnagle, G. B., Dickson, R. P., & Lukacs, N. W. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.108 · Cited by 535
Self-citationThe Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases
Zhang, D., Li, S., Wang, N., Tan, H., Zhang, Z., & Feng, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00301 · Cited by 453
The Role of Enterobacteriaceae in Gut Microbiota Dysbiosis in Inflammatory Bowel Diseases
Baldelli, V., Scaldaferri, F., Putignani, L., & CHIERICO, F. D. (2021) · Microorganisms · doi:10.3390/microorganisms9040697 · Cited by 389
The promise of the gut microbiome as part of individualized treatment strategies
Schupack, D. A., Mars, R. A. T., Voelker, D. H., Abeykoon, J. P., & Kashyap, P. C. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00499-1 · Cited by 217
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186
Ashley, S. L., Sjoding, M. W., Popova, A. P., Cui, T. X., Hoostal, M. J., Schmidt, T. M., Branton, W. R., Dieterle, M. G., Falkowski, N. R., Baker, J. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aau9959 · Cited by 170
Self-citationZhou, X., Shen, X., Johnson, J. S., Spakowicz, D. J., Agnello, M., Zhou, W., Avina, M., Honkala, A. T., Chleilat, F., Chen, S. J., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.02.012 · Cited by 181
Zhang, X., Zou, Q., Zhao, B., Zhang, J., Zhao, W., Li, Y., Liu, R., Liu, X., & Liu, Z. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101535 · Cited by 166
Qiao, S., Li, B., Wang, K., Sun, S., Liao, M., Liu, C., Zhou, N., Ma, K., Zhang, Y., Chen, Y., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108005 · Cited by 147
Chronic Rhinosinusitis: Potential Role of Microbial Dysbiosis and Recommendations for Sampling Sites
Copeland, E., Leonard, K., Carney, R. L., Kong, J. S., Forer, M., Naidoo, Y., Oliver, B. G. G., Seymour, J. R., Woodcock, S., Burke, C., et al. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00057 · Cited by 106
Li, K., Chen, Z., Huang, Y. H., Zhang, R., Luan, X.-Q., Lei, T., & Chen, L. (2019) · Respiratory Research · doi:10.1186/s12931-019-1246-0 · Cited by 110
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease
Arron, H. E., Marsh, B. D., Khan, M. A., Jaeger, B., Kell, D., & Pretorius, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1386607 · Cited by 127
Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study
for the PROSPECT Investigators, Lamarche, D., Canadian Critical Care Trials Group, Canadian Critical Care Translational Biology Group, Johnstone, J., Zytaruk, N. L., Clarke, F. J., Hand, L. E., Loukov, D., Szamosi, J. C., et al. (2018) · Respiratory Research · doi:10.1186/s12931-018-0950-5 · Cited by 100
The Lung Microbiota Affects Pulmonary Inflammation and Oxidative Stress Induced by PM 2.5 Exposure
Wang, S., Zhou, Q., Tian, Y., & Hu, X. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c08888 · Cited by 96
Zádori, Z., Király, K. P., Al‐Khrasani, M., & Gyires, K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108327 · Cited by 92
Shen, J., Wang, S., He, X., Han, S., Wang, Q., Wu, Z., Zhuge, A., Li, S., Chen, H., Lv, L., et al. (2023) · Food & Function · doi:10.1039/d3fo04051h · Cited by 91
Lung inflammation and disease: A perspective on microbial homeostasis and metabolism
Méndez, R., Banerjee, S., Bhattacharya, S. K., & Banerjee, S. (2018) · IUBMB Life · doi:10.1002/iub.1969 · Cited by 86
Commensal inter-bacterial interactions shaping the microbiota
Kern, L., Abdeen, S. K., Kolodziejczyk, A. A., & Elinav, E. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.07.011 · Cited by 82
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Mukherjee, S., & Hanidziar, D. (2018) · Europe PMC (PubMed Central) · Cited by 70
Daniel, S., Phillippi, D., Schneider, L. J., Nguyen, K. N., Mirpuri, J., & Lund, A. K. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00393-9 · Cited by 67
Kristensen, M., Prevaes, S. M. P. J., Kalkman, G., Tramper‐Stranders, G. A., Hasrat, R., Groot, K. M. D. W., Janssens, H. M., Tiddens, H. A. W. M., van Westreenen, M., Sanders, E. A. M., et al. (2020) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2020.04.007 · Cited by 66
van Dorst, J. M., Tam, R. Y., & Ooi, C. Y. (2022) · Nutrients · doi:10.3390/nu14030480 · Cited by 65
Probiotics in the prophylaxis of COVID-19: something is better than nothing
Gohil, K. N., Samson, R., Dastager, S. G., & Dharne, M. S. (2020) · 3 Biotech · doi:10.1007/s13205-020-02554-1 · Cited by 60
Chhibber‐Goel, J., Gopinathan, S., & Sharma, A. K. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00407-7 · Cited by 57
Tam, R. Y., van Dorst, J. M., McKay, I. R., Coffey, M. J., & Ooi, C. Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030649 · Cited by 60
Cancer-associated inflammation: pathophysiology and clinical significance
Pęczek, P., Gajda, M., Rutkowski, K., Fudalej, M. M., Deptała, A., & Badowska-Kozakiewicz, A. M. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04399-y · Cited by 57
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Abdel-Rahman, L. I. H., & Morgan, X. C. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac194 · Cited by 56
Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome
McCall, L., Tripathi, A., Vargas, F., Knight, R. D., Dorrestein, P. C., & Siqueira-Neto, J. L. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006344 · Cited by 49
Impact of air pollution on respiratory microbiome: A narrative review
Vieceli, T., Tejada, S., Martínez-Reviejo, R., Pumarola, T., Schrenzel, J., WATERER, G. W., & Rello, J. (2022) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2022.103336 · Cited by 54
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Russo, C., Colaianni, V., Ielo, G., Valle, M. S., Spicuzza, L., & Malaguarnera, L. (2022) · Biomedicines · doi:10.3390/biomedicines10061337 · Cited by 41
The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?
Weinberg, F. D., Dickson, R. P., Nagrath, D., & Ramnath, N. (2020) · Cancers · doi:10.3390/cancers13010013 · Cited by 41
Self-citationPathophysiology of the Acute Respiratory Distress Syndrome
Sinha, P., & Bos, L. D. J. (2021) · Critical Care Clinics · doi:10.1016/j.ccc.2021.05.005 · Cited by 44
Bos, L. D. J., Meinardi, S., Blake, D. R., & Whiteson, K. (2016) · Journal of Breath Research · doi:10.1088/1752-7163/10/4/047103 · Cited by 42
Sarcopenia in Children with Solid Organ Tumors: An Instrumental Era
Ritz, A., Lurz, E., & Berger, M. (2022) · Cells · doi:10.3390/cells11081278 · Cited by 37
Lázár, B., László, S. B., Hutka, B., Tóth, A. S., Mohammadzadeh, A., Berekméri, E., Ágg, B., Balogh, M., Sajtos, V., Király, K. P., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114590 · Cited by 37
Inhalation Injury: Unmet Clinical Needs and Future Research
Dyamenahalli, K. U., Garg, G., Shupp, J. W., Kuprys, P. V., Choudhry, M. A., & Kovacs, E. J. (2019) · Journal of Burn Care & Research · doi:10.1093/jbcr/irz055 · Cited by 39
Immunological consequences of microbiome-based therapeutics
Alam, M. Z., Maslanka, J. R., & Abt, M. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1046472 · Cited by 38
The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases
Gonçalves, S. M., Lagrou, K., Duarte-Oliveira, C., Maertens, J. A., Cunha, C., & Carvalho, A. (2017) · Virulence · doi:10.1080/21505594.2016.1257458 · Cited by 32
Resolvin D1 regulates epithelial ion transport and inflammation in cystic fibrosis airways
Ringholz, F., Higgins, G., Hatton, A., Sassi, A., Moukachar, A., Torre, C. F., Hollenhorst, M. I., Sermet‐Gaudelus, I., Harvey, B. J., McNally, P., et al. (2017) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2017.11.017 · Cited by 32
Sui, G., Jia, L., Quan, D., Zhao, N., & Yang, G. (2021) · Aging · doi:10.18632/aging.203460 · Cited by 34
Thapa, R., Magar, A. T., Shrestha, J., Panth, N., Idrees, S., Sadaf, T., Bashyal, S., Elwakil, B. H., Sugandhi, V. V., Rojekar, S. V., et al. (2024) · MedComm · doi:10.1002/mco2.70018 · Cited by 33
Li, Y., Li, N., Liu, J., Wang, T., Dong, R., Ge, D., & Peng, G. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s352706 · Cited by 31
Crawford, M. S., Nordgren, T. M., & McCole, D. F. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00423.2020 · Cited by 33
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Chancharoenthana, W., Sutnu, N., Visitchanakun, P., Sawaswong, V., Chitcharoen, S., Payungporn, S., Schuetz, A., Schultz, M. J., & Leelahavanichkul, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940935 · Cited by 26
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Zhang, Q., Tang, H., Yan, C., Han, W., Peng, L., Xu, J., Chen, X., Langford, P. R., Bei, W., Huang, Q., et al. (2022) · Infection and Immunity · doi:10.1128/iai.00239-22 · Cited by 18
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Jin, A., Zhao, Y., Yuan, Y., Ma, S., Chen, J., Yang, X., Lu, S., & Sun, Q. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100952 · Cited by 15
Zhang, Q., Song, J., Wu, H., Wang, L., Zhuo, G., Li, H., He, S., Pan, Y., & Liu, G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112984 · Cited by 16
Costantini, C., Nunzi, E., Spolzino, A., Palmieri, M., Renga, G., Zelante, T., Englmaier, L., Coufalíková, K., Spáčil, Z., Borghi, M., et al. (2021) · Infection and Immunity · doi:10.1128/iai.00105-21 · Cited by 16
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Ajibola, O., Penumutchu, S., Gulumbe, B. H., Aminu, U., & Belenky, P. A. (2023) · Research Square · doi:10.21203/rs.3.rs-2832346/v1 · Cited by 15
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Kidess, E., Kleerebezem, M., & Brugman, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.729053 · Cited by 11
Hanusch, B., Brinkmann, F., Mayorandan, S., Chobanyan-Jürgens, K., Wiemers, A., Jansen, K., Ballmann, M., Choudhury, A. R., Bollenbach, A., Derichs, N., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123802 · Cited by 10
Begum, A., Rabbane, M. G., Moniruzzaman, M., Hasan, M. R., & Chang, X. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04524-1 · Cited by 9
Knysh, O. V., Isayenko, O. Y., Voyda, Y. V., Kizimenko, O. O., & Babych, Y. M. (2019) · Regulatory Mechanisms in Biosystems · doi:10.15421/021938 · Cited by 9
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Sumner, J. T., Huttelmaier, S., Pickens, C. I., Moghadam, A. A., Abdala‐Valencia, H., Shen, J., Peltekian, A., Misharin, A. V., Wolfe, A. R., Szabo, A. L., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.11.011 · Cited by 9
Su, Y., Zhang, Y., & Xu, J. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1279239 · Cited by 8
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Jennings, R. T., Singh, A. K., & Knaus, U. G. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.03.002 · Cited by 8
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Moffatt, L. T., Madrzykowski, D. M., Gibson, A. L. F., Powell, H. M., Cancio, L. C., Wade, C. E., Choudhry, M. A., Kovacs, E. J., Finnerty, C. C., Majetschak, M., et al. (2020) · Journal of Burn Care & Research · doi:10.1093/jbcr/irz207 · Cited by 6
Shi, X., Gao, Z., Lin, Q., Zhao, L., Ma, Q., Kang, Y., & Yu, J. M. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.03.009 · Cited by 6
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Liang, X., Liu, T., Zhang, Z., & Yu, Z. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0904-0_16 · Cited by 6
Wang, L., Zhang, G., Li, Q., Lu, F., Yang, K., & Dai, X. (2024) · The FASEB Journal · doi:10.1096/fj.202301218r · Cited by 5
Zhang, Z., Wang, W., Hu, J.-C., Lu, J., Feng, R., Xu, S., Wang, L., Fu, J., Yu, H., Xu, H. X., et al. (2025) · Engineering · doi:10.1016/j.eng.2025.04.018 · Cited by 5
Cystic fibrosis and inflammatory bowel disease: parallels in gut physiology and microbiota
Barrack, K. E., & O’Toole, G. A. (2025) · Journal of Bacteriology · doi:10.1128/jb.00167-25 · Cited by 6
Hernandez, A. R., Parker, E. S., Babar, M., Banerjee, A., Ding, S., Simley, A. L., & Buford, T. W. (2024) · Aging Brain · doi:10.1016/j.nbas.2024.100119 · Cited by 5
Profir, M., Pavelescu, L. A., Mogoș, G. F. R., Stancu, A. C., Creţoiu, S. M., & Marinescu, I. P. (2026) · Life · doi:10.3390/life16030505 · Cited by 5
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Janahi, I. A., & Rehman, A. (2017) · InTech eBooks · doi:10.5772/67846 · Cited by 3
Johnson, A. C. B., & Biddle, A. S. (2021) · Animals · doi:10.3390/ani11071975 · Cited by 4
Hall, A. N., Manuja, S., Payling, L. M., Romero, L. F., Hoerr, F. J., Shields, J., Hofacre, C. L., Susanti, D., Gangaiah, D., Plata, G., et al. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-00916-w · Cited by 3
Won, E. J., Lee, Y. J., Kim, M., Kim, T., Shin, H., Kim, T.-O., & Kwon, Y. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309446 · Cited by 3
Microbial Metabolites in Cystic Fibrosis: A Target for Future Therapy?
Stefanie Widder, A., & Knapp, S. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0081ed · Cited by 3
Zhou, Y., He, X., Tang, J., Zhang, D., Liu, Y., Xue, Y., Jiang, N., Zhang, J., & Wang, X. (2024) · ERJ Open Research · doi:10.1183/23120541.01045-2023 · Cited by 2
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Комиссарова, О. Г., Шорохова, В. А., & Абдуллаев, Р. Ю. (2021) · Вестник ЦНИИТ · doi:10.7868/s258766782103002x · Cited by 2
Aslam, M. (2023) · Preprints.org · doi:10.20944/preprints202303.0040.v1 · Cited by 1
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Liu, R., Wang, Y., & Cheng, D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.12.571369 · Cited by 1
Стома, И. О. (2020) · Infectious diseases News Opinions Training · doi:10.33029/2305-3496-2020-9-1-109-115
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Hosang, L. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7695
Metadata
- Authors
- Scales, B. S., Dickson, R. P., & Huffnagle, G. B.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Huffnagle, Gary B
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06-30
- Volume
- 100
- Issue
- 5
- Pages
- 943-950
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- PMC
- PMC5069096
- OpenAlex
- W2471545969
- Cited by
- 109
- References
- 85
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 14 · 2023: 8 · 2022: 13 · 2021: 21 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 5
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- U.S. National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL114447, T32HL00774921)
- Nesbitt Program for Cystic Fibrosis Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- inflammation, gut microbiota, lung microbiome, facultative anaerobes, anaerobic respiration, reactive nitrogen species, nitrate, Escherichia coli, Pseudomonas aeruginosa, Gammaproteobacteria, colonic inflammation, cystic fibrosis, bacterial blooms, terminal electron acceptors
- MeSH terms
- Gastrointestinal Microbiome, Anaerobiosis, Colitis, Cystic Fibrosis, Escherichia coli Infections, Humans, Inflammation, Lung, Mucus, Nitric Oxide, Nitrogen, Oxidation-Reduction, Pseudomonas Infections, Gammaproteobacteria, Feedback, Physiological, Gastrointestinal Tract, Nitric Oxide Synthase Type II, Microbiota
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