Cited by 258Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Negative regulation of cytokine signaling

Greenhalgh, Christopher J, Hilton, Douglas J·2001·Journal of Leukocyte Biology

Open this paper in CoChat — free account

Abstract

Cytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mechanism of activation. Rapid and efficient attenuation of cytokine signals is crucial to maintaining regulation of these processes and to preventing toxic side effects. Phosphatases have been shown to be involved in these regulatory processes, but more recent research has seen the discovery of two new families of negative regulators, the suppressor of cytokine signaling (SOCS) and protein inhibitors of signal transducer and activator of transcription (STAT) (PIAS) protein families. SOCS proteins are induced by and inhibit many cytokine-signaling systems in a classic negative-feedback loop, and the generation of transgenic and knockout models has greatly increased our understanding of their physiological functions. PIAS proteins interact with the transcriptional mediators of cytokine action, the STATs, to suppress their DNA-binding activity. These three classes of molecules form what is now emerging as an integrated system for deactivating cytokine signaling at a number of levels, from the receptor to the transcription factor.

Integrity signals

Registry

Crossref · 10.1189/jlb.70.3.348

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Self-citation
Interleukin-10
Moore, K. W., O’Garra, A., Malefyt, R. D. W., Vieira, P., & Mosmann, T. R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001121 · Cited by 1,883
Normal growth and development in the absence of hepatic insulin-like growth factor I
Yakar, S., Liu, J., STANNARD, B. S., Butler, A. A., Accili, D., Sauer, B., & LeRoith, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7324 · Cited by 1,418
A new protein containing an SH2 domain that inhibits JAK kinases
Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997) · Nature · doi:10.1038/43213 · Cited by 1,408
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
Teglund, S., McKay, C., Schuetz, E. G., van Deursen, J. M., Stravopodis, D. J., Wang, D., Brown, M. P., Bodner, S. M., Grosveld, G. C., & Ihle, J. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81444-0 · Cited by 1,266
Stat5a is mandatory for adult mammary gland development and lactogenesis.
Liu, X., Robinson, G. W., Wagner, K. U., Garrett, L., Wynshaw-Boris, A., & Hennighausen, L. (1997) · Genes & Development · doi:10.1101/gad.11.2.179 · Cited by 1,111
Structure and function of a new STAT-induced STAT inhibitor
Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,040
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
Udy, G. B., Towers, R. P., Snell, R. G., Wilkins, R. J., Park, S.-H., Ram, P. A., Waxman, D. J., & Davey, H. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7239 · Cited by 991
Specific Inhibition of Stat3 Signal Transduction by PIAS3
Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., & Shuai, K. (1997) · Science · doi:10.1126/science.278.5344.1803 · Cited by 980

Flagged first, then by citations

Show all 93 references

Research works printed but not linked: 1

Gresser, 1982, Can interferon induce diseasearticle-title, Interferon, 4, 95

Sorted by citations

Items 101–200 of 258

Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
Wang, T.-Y., Sun, M., Zhang, H., Wang, G., Zhan, G., Tian, Z., Cai, X., Su, C., & Tang, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.693799 · Cited by 53
Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling
Yan, M., Luo, J.-K., Ritchie, K. J., Sakai, I., Takeuchi, K., Ren, R., & Zhang, D. (2007) · Blood · doi:10.1182/blood-2006-07-033209 · Cited by 49
Influence of Sutherlandia frutescens extracts on cell numbers, morphology and gene expression in MCF-7 cells
Stander, A., Marais, S., Steynberg, T. J., Theron, D., Joubert, F., Albrecht, C., & Joubert, A. M. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.03.013 · Cited by 48
RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules
Hashimoto, K., Ishibashi, K., Ishioka, K., Zhao, D., Sato, M., Ohara, S., Abe, Y., Kawasaki, Y., Sato, Y., Yokota, S., et al. (2009) · Virology · doi:10.1016/j.virol.2009.06.026 · Cited by 46
Indispensable Role of Stat5a in Stat6-Independent Th2 Cell Differentiation and Allergic Airway Inflammation
Takatori, H., Nakajima, H., Hirose, K., Kagami, S., Tamachi, T., Suto, A., Suzuki, K., Saito, Y., & Iwamoto, I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3734 · Cited by 46
Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo
Spight, D., Zhao, B., Haas, M., Wert, S. E., Denenberg, A. G., & Shanley, T. P. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00122.2004 · Cited by 45
Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling
Zhang, B., Xie, S., Su, Z., Song, S., Xu, H., Chen, G., Cao, W., Yin, S., Gao, Q., & Wang, H. (2016) · Scientific Reports · doi:10.1038/srep21132 · Cited by 45
Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells
Tai, Z., Lin, Y., He, Y., Huang, J., Guo, J., Yang, L., Zhang, G., & Wang, F. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.039 · Cited by 42
Suppressors of Cytokine Signaling Regulate Fc Receptor Signaling and Cell Activation during Immune Renal Injury
Gómez‐Guerrero, C., López‐Franco, Ó., Sanjuán, G., Hernández-Vargas, P., Suzuki, Y., Ortiz-Muñoz, G., Blanco, J., & Egido, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6969 · Cited by 44
Statins induce suppressor of cytokine signaling‐3 in macrophages
Huang, K., Chen, C.-W., Chen, J.-C., & Lin, W. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01297-3 · Cited by 44
Expression of SOCS1-7 and CIS mRNA in porcine tissues
Delgado-Ortega, M., Melo, S., & Meurens, F. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.08.002 · Cited by 45
Regulation of T cell homeostasis by JAKs and STATs
Ross, J. A., Nagy, Z. S., Cheng, H., Stepkowski, S. M., & Kirken, R. A. (2007) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-007-0030-x · Cited by 45
Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity†
Wang, H., Park, O., Lafdil, F., Shen, K., Horiguchi, N., Yin, S., Fu, X.-Y., Kunos, G., & Gao, B. (2009) · Hepatology · doi:10.1002/hep.23430 · Cited by 41
Activation of STAT Signaling Pathways and Induction of Suppressors of Cytokine Signaling (SOCS) Proteins in Mammalian Lens by Growth Factors
Ebong, S., Yu, C., Carper, D. A., Chepelinsky, A. B., & Egwuagu, C. E. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0311 · Cited by 39
Differential effects of SOCS2 on neuronal differentiation and morphology
Scott, H. J., Stebbing, M. J., Walters, C. E., McLenachan, S., Ransome, M. I., Nichols, N. R., & Turnley, A. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.032 · Cited by 40
The glycobiology of implantation
Carson, D. D. (2002) · Frontiers in bioscience · doi:10.2741/a858 · Cited by 40
Protein Phosphatase 2A Regulates Interleukin-2 Receptor Complex Formation and JAK3/STAT5 Activation
Ross, J. A., Cheng, H., Nagy, Z. S., Frost, J. A., & Kirken, R. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053843 · Cited by 39
Activation of innate immunity (NK/IFN-γ) in rat allogeneic liver transplantation: contribution to liver injury and suppression of hepatocyte proliferation
Shen, K., Zheng, S.-S., Park, O., Wang, H., Sun, Z., & Gao, B. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00554.2007 · Cited by 37
Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes
Grutkoski, P. S., Chen, Y., Chung, C., & Ayala, A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303108 · Cited by 37
Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges
Arshad, S., Naveed, M., Ullia, M., Javed, K., Butt, A. J., Khawar, M., & Amjad, F. (2020) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2018-0160 · Cited by 37
Role of SOCS2 in growth hormone actions
Turnley, A. M. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.01.006 · Cited by 35
The anti-inflammatory effect of ferulic acid is via the modulation of NFκB-TNF-α-IL-6 and STAT1-PIAS1 signaling pathways in 2-methoxyethanol-induced testicular inflammation in rats
Adeyi, O. E., Somade, O. T., Ajayi, B. O., James, A. S., Adeboye, T. R., Olufemi, D. A., Oyinlola, E. V., Sanyaolu, E. T., & Mufutau, I. O. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100464 · Cited by 38
The Intracellular Delivery of a Recombinant Peptide Derived from the Acidic Domain of PIAS3 Inhibits STAT3 Transactivation and Induces Tumor Cell Death
Borghouts, C., Tittmann, H., Delis, N., Kirchenbauer, M., Brill, B., & Groner, B. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0417 · Cited by 34
Suppressor of cytokine signaling 2 (SOCS2) negatively regulates the expression of antimicrobial peptides by affecting the Stat transcriptional activity in shrimp Marsupenaeus japonicus
Sun, J., Lan, J.-F., Xu, J., Niu, G.-J., & Wang, J. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.07.037 · Cited by 34
(Putative) sex differences in neuroimmune modulation of memory
Tronson, N. C., & Collette, K. M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23921 · Cited by 36
Interleukin signaling
Vosshenrich, C. A. J., & Santo, J. P. D. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01286-1 · Cited by 34
Epithelial induction of porcine suppressor of cytokine signaling 2 (SOCS2) gene expression in response to Entamoeba histolytica
Bruel, T., Guibon, R., Melo, S., Guillén, N., Salmon, H., Girard‐Misguich, F., & Meurens, F. (2010) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2009.12.017 · Cited by 36
Type I Vs. Type II Cytokine Levels as a Function of SOD1 G93A Mouse Amyotrophic Lateral Sclerosis Disease Progression
Jeyachandran, A., Mertens, B., McKissick, E. A., & Mitchell, C. S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00462 · Cited by 36
Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications
Solouki, S., August, A., & Huang, W. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.008 · Cited by 37
Angiotensin II (AngII) induces the expression of suppressor of cytokine signaling (SOCS)-3 in rat hypothalamus - a mechanism for desensitization of AngII signaling
Torsoni, M. A., Carvalheira, J. B. C., Calegari, V. C., Bezerra, R. M. N., Saad, M., Gontijo, J. A. R., & Velloso, L. A. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810117 · Cited by 32
Effects of Sijunzi decoction and Yupingfeng powder on expression of janus kinase-signal transducer and activator of transcription signal pathway in the brain of spleen-deficiency model rats
Xiong, B., & Huinan, Q. (2013) · 中医杂志：英文版 · doi:10.1016/s0254-6272(13)60105-3 · Cited by 31
Identification and expression analysis of suppressors of cytokine signaling (SOCS) of Japanese flounder Paralichthys olivaceus
Thanasaksiri, K., Hırono, I., & Kondo, H. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.09.018 · Cited by 31
Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+T cells from patients with rheumatoid arthritis
Yamana, J., Yamamura, M., Okamoto, A., Aita, T., Iwahashi, M., Sunahori, K., & Makino, H. (2004) · Arthritis Research & Therapy · doi:10.1186/ar1445 · Cited by 31
Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1)
Buro, L. J., Chipumuro, E., & Henriksen, M. A. (2010) · Epigenetics & Chromatin · doi:10.1186/1756-8935-3-16 · Cited by 31
Thyrotropin-Mediated Repression of Class II Trans -Activator Expression in Thyroid Cells: Involvement of STAT3 and Suppressor of Cytokine Signaling
Kim, H., Suh, J. M., Hwang, E. S., Kim, D. W., Chung, H. K., Song, J. H., Hwang, J. H., Park, K. C., Ro, H. K., Jo, E., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.616 · Cited by 31
Targeting steroid resistance in T-cell acute lymphoblastic leukemia
Smedt, R. D., Morscio, J., Goossens, S., & Vlierberghe, P. V. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100591 · Cited by 30
Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2
Ransome, M. I., & Turnley, A. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.041 · Cited by 31
Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels
Kano, G., Morimoto, A., Takanashi, M., Hibi, S., Sugimoto, T., Inaba, T., Yagi, T., & Imashuku, S. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190801993462 · Cited by 29
Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice
Gavito, A., Bautista, D., Suárez, J., Badran, S., Arco, R., Pavón, F. J., Serrano, A., Rivera, P., Decara, J. M., Cuesta, A. L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157956 · Cited by 28
SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade
Pello, Ó. M., Moreno-Ortíz, M. D. C., Rodrı́guez-Frade, J. M., Martínez‐Muñoz, L., Lucas, D., Gómez, L., Lucas, P., Samper, E., Aracil, M., Martínez‐A, C., et al. (2006) · Blood · doi:10.1182/blood-2006-02-006353 · Cited by 28
SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells
Ouyang, X., Fujimoto, M., Nakagawa, R., Serada, S., Tanaka, T., Nomura, S., Kawase, I., Kishimoto, T., & Naka, T. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20579 · Cited by 27
Dampening of IFN-γ-Inducible Gene Expression in Human Choriocarcinoma Cells Is Due to Phosphatase-Mediated Inhibition of the JAK/STAT-1 Pathway
Choi, J. C., Holtz, R., Petroff, M. G., Alfaidy, N., & Murphy, S. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1598 · Cited by 27
SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis
Chung, C., Chen, Y., Grutkoski, P. S., Doughty, L., & Ayala, A. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0059-7 · Cited by 26
Suppression of Growth Hormone (GH) Janus Tyrosine Kinase 2/Signal Transducer and Activator of Transcription 5 Signaling Pathway in Transgenic Mice Overexpressing Bovine GH
Miquet, J. G., Sotelo, A. I., Bartke, A., & Turyn, D. (2004) · Endocrinology · doi:10.1210/en.2003-1498 · Cited by 26
Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity
Watcharanurak, K., Zang, L., Nishikawa, M., Yoshinaga, K., Yamamoto, Y., Takahashi, Y., Ando, M., Saito, K., Watanabe, Y., & Takakura, Y. (2014) · Gene Therapy · doi:10.1038/gt.2014.54 · Cited by 25
Role of Hypermethylation on Carcinogenesis in the Pancreas
Kuroki, T., Tajima, Y., & Kanematsu, T. (2004) · Surgery Today · doi:10.1007/s00595-004-2858-6 · Cited by 24
STAT 5a expression in various lesions of the breast
Bratthauer, G. L., Strauss, B. L., & Tavassoli, F. A. (2005) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-005-0056-6 · Cited by 24
CUEDC2 (CUE Domain-containing 2) and SOCS3 (Suppressors of Cytokine Signaling 3) Cooperate to Negatively Regulate Janus Kinase 1/Signal Transducers and Activators of Transcription 3 Signaling
Zhang, W., Wang, L., Wang, Q., Luo, X. G., Fang, D., Chen, Y., Pan, X., Man, J., Xia, Q., Jin, B., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276832 · Cited by 23
Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages
Litherland, S. A., Xie, T. X., Grebe, K. M., Davoodi‐Semiromi, A., Elf, J. L., Belkin, N. S., Moldawer, L. L., & Clare-Salzler, M. J. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.02.001 · Cited by 21
The logic of communication: roles for mobile transcription factors in plants
Long, Y., Scheres, B., & Blilou, I. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/eru548 · Cited by 25
Effects of Salmonella on spatial-temporal processes of jejunal development in chickens
Schokker, D., Smits, M. A., Hoekman, A. J. W., Parmentier, H. K., & Rebel, J. M. J. (2010) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2010.05.013 · Cited by 22
A de novo transcriptome analysis shows that modulation of the JAK-STAT signaling pathway by salmonid alphavirus subtype 3 favors virus replication in macrophage/dendritic-like TO-cells
Xu, C. Y., Evensen, Ø., & Munang’andu, H. M. (2016) · BMC Genomics · doi:10.1186/s12864-016-2739-6 · Cited by 21
Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells
Ndiaye, K., Castonguay, A., Benoit, G., Silversides, D. W., & Lussier, J. G. (2016) · Journal of Ovarian Research · doi:10.1186/s13048-016-0280-5 · Cited by 21
Janus Tyrosine Kinases and Signal Transducers and Activators of Transcription Regulate Critical Functions of T Cells in Allograft Rejection and Transplantation Tolerance
Stepkowski, S. M., & Kirken, R. A. (2006) · Transplantation · doi:10.1097/01.tp.0000228903.03118.be · Cited by 21
Docosahexaenoic acid ameliorates autoimmune inflammation by activating GPR120 signaling pathway in dendritic cells
Feng, C., Li, L., Li, Q., Switzer, K. C., Liu, M., Han, S., & Zheng, B. Q. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107698 · Cited by 20
Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex
Truong, A. D., Hoang, C. T., Hong, Y., Lee, J., Lee, K., Lillehoj, H. S., & Hong, Y. H. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.09.019 · Cited by 20
Ocular Inflammatory Diseases: Molecular Pathogenesis and Immunotherapy
Egwuagu, C. E., Sun, L., Kim, S.-H., & Dambuza, I. M. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150731095426 · Cited by 19
Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid
Darra, E., Shoji, K., Mariotto, S., & Suzuki, H. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0060-3 · Cited by 19
SOCS genes expression during physiological and perturbed implantation in bovine endometrium
Carvalho, A. V., Reinaud, P., Forde, N., Healey, G. D., Eozénou, C., Giraud‐Delville, C., Mansouri-Attia, N., Gall, L., Richard, C., Lonergan, P., et al. (2014) · Reproduction · doi:10.1530/rep-14-0214 · Cited by 20
Suppression of STAT3 NH2‐terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de‐repression by microRNA‐21
Ray, S., Coulter, D. W., Gray, S. D., Sughroue, J. A., Roychoudhury, S., McIntyre, E. M., Chaturvedi, N. K., Bhakat, K. K., Joshi, S. S., McGuire, T. R., et al. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22778 · Cited by 18
Interferon-??, but not interferon-??, induces SOCS 3 expression in human melanoma cell lines
Kovařík, A., Fojtová, M., Boudný, V., Adámková, L., Lauerová, L., & Kovařík, J. (2005) · Melanoma Research · doi:10.1097/00008390-200512000-00001 · Cited by 20
JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells
Zhang, Y., Zhang, L., Zuo, Q., Wang, Y., Zhang, Y., Xu, Q., Li, B., & Chen, G. (2017) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-017-0167-9 · Cited by 18
Interferon-γ
Schreiber, G., & Schreiber, R. D. (2003) · Elsevier eBooks · doi:10.1016/b978-012689663-3/50028-4 · Cited by 19
Suppressor of cytokine signaling 2 ( Socs2 ) deletion protects bone health of mice with DSS-induced inflammatory bowel disease
Dobie, R., MacRae, V. E., Pass, C., Milne, E., Ahmed, S. F., & Farquharson, C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.028456 · Cited by 17
Direct interaction of natural and synthetic catechins with signal transducer activator of transcription 1 affects both its phosphorylation and activity
Menegazzi, M., Mariotto, S., Bosco, M. D., Darra, E., Vaiana, N., Shoji, K., Abdel‐Azeim, S., Maréchal, J., Pérahia, D., Suzuki, H., et al. (2013) · FEBS Journal · doi:10.1111/febs.12618 · Cited by 18
CYP2E1-Catalyzed Alcohol Metabolism: Role of Oxidant Generation in Interferon Signaling, Antigen Presentation and Autophagy
Osna, N. A., & Donohue, T. M. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5881-0_6 · Cited by 17
Molecular cloning of chicken interleukin-17B, which induces proinflammatory cytokines through activation of the NF-κB signaling pathway
Hoang, C. T., Hong, Y., Truong, A. D., Lee, J., Lee, K., & Hong, Y. H. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.04.010 · Cited by 17
Isoliquiritigenin attenuates MiR-21 expression via induction of PIAS3 in breast cancer cells
Ning, S., Ma, X., Zhu, D., Shen, Z., Liu, J., Liu, Y., Chen, J., & Li, Z. (2017) · RSC Advances · doi:10.1039/c6ra25511f · Cited by 16
Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung
Zimmer, J., Weitnauer, M., Boutin, S., Küblbeck, G., Thiele, S., Walker, P., Lasitschka, F., Lunding, L. P., Orinska, Z., Vock, C., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00514 · Cited by 17
Aberrant DNA Methylation in Chronic Myeloid Leukemia: Cell Fate Control, Prognosis, and Therapeutic Response
Behzad, M. M., Shahrabi, S., Jaseb, K., Bertacchini, J., Ketabchi, N., & Saki, N. (2018) · Biochemical Genetics · doi:10.1007/s10528-018-9841-1 · Cited by 16
Activation of STAT3 signaling in human stomach adenocarcinoma drug-resistant cell line and its relationship with expression of vascular endothelial growth factor
Yu, L.-F. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i6.875 · Cited by 15
Multifaceted Mechanisms for Cell Survival and Drug Targeting in Chronic Myelogenous Leukemia
Kuroda, J., Shimura, Y., Yamamoto‐Sugitani, M., Sasaki, N., & Taniwaki, M. (2012) · Current Cancer Drug Targets · doi:10.2174/156800913804486638 · Cited by 15
Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation
Sheu, M., Shen, C.-C., Jheng, J.-R., & Chiang, C. (2017) · Oncotarget · doi:10.18632/oncotarget.14808 · Cited by 15
Labda-8(17),12,14-trien-19-oic Acid Contained in Fruits ofCupressus sempervirensSuppresses Benign Prostatic Hyperplasia in Rat andIn VitroHuman Models Through Inhibition of Androgen and STAT-3 Signaling
Verma, V., Sharma, V., Singh, V., Kumar, R., Khan, M. F., Singh, A. K., Sharma, R., Arya, K. R., Maikhuri, J. P., Dalela, D., et al. (2014) · Phytotherapy Research · doi:10.1002/ptr.5114 · Cited by 14
Taenia crassiceps infection and its excreted/secreted products inhibit STAT1 activation in response to IFN-γ
Becerra-Díaz, M., & Terrazas, L. I. (2014) · International Journal for Parasitology · doi:10.1016/j.ijpara.2014.03.012 · Cited by 13
DNA methyltransferase 1(DNMT1) induced the expression of suppressors of cytokine signaling3 (Socs3) in a mouse model of asthma
Verma, M., Chattopadhyay, B., Kumar, S., Kumar, K., & Verma, D. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3312-5 · Cited by 13
Functional Impairment of Myeloid Dendritic Cells during Advanced Stage of HIV-1 Infection: Role of Factors Regulating Cytokine Signaling
Sachdeva, M., Sharma, A., & Arora, S. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140852 · Cited by 13
Molecular components of JAK/STAT signaling pathway and its interaction with transcription machinery
Shaposhnikov, A. V., Комарьков, И. Ф., Lebedeva, L. A., & Shidlovskii, Y. V. (2013) · Molecular Biology · doi:10.1134/s0026893313030126 · Cited by 13
SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway
Yuan (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000507 · Cited by 13
Lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing
Nakajima, H., Suzuki, K., & Iwamoto, I. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00048-0 · Cited by 14
Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein
Humpoliková-Adámková, L., Kovařík, J., Dušek, L., Lauerová, L., Boudný, V., Fait, V., Fojtová, M., Krejčí, E., & Kovařı́k, A. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.01.009 · Cited by 13
A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model
Post, J., Kogel, V., Schaffrath, A., Lohmann, P., Shah, N. J., Langen, K., Willbold, D., Willuweit, A., & Kutzsche, J. (2021) · Molecules · doi:10.3390/molecules26061590 · Cited by 12
Increased expression of negative regulators of cytokine signaling during chronic HIV disease cause functionally exhausted state of dendritic cells
Sachdeva, M., Sharma, A., & Arora, S. K. (2017) · Cytokine · doi:10.1016/j.cyto.2016.08.010 · Cited by 12
Negative regulation of Smad2 by PIASy is required for properXenopusmesoderm formation
Daniels, M., Shimizu, K., Zorn, A. M., & Ohnuma, S. (2004) · Development · doi:10.1242/dev.01449 · Cited by 12
Stimulation of Hepatic Signal Transducer and Activator of Transcription 5b by GH Is Not Altered by 3-Methylcholanthrene
Timsit, Y., & Riddick, D. S. (2002) · Endocrinology · doi:10.1210/en.2002-220212 · Cited by 12
Antheraea pernyi Suppressor of Cytokine Signaling 2 Negatively Modulates the JAK/STAT Pathway to Attenuate Microbial Infection
Kausar, S., Gul, I., Liu, R., Ke, X., Dong, Z., Abbas, M. N., & Cui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810389 · Cited by 11
Role of the SOCS in monocytes/macrophages-related pathologies. Are we getting closer to a new pharmacological target?
Łabuzek, K., Suchy, D., Gabryel, B., Pierzchała, O., & Okopień, B. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70902-7 · Cited by 11
Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: Activation of the interferon response pathways
Dobbin, E., Graham, C., Freeburn, R. W., Unwin, R. D., Griffiths, J. R., Pierce, A., Whetton, A. D., & Wheadon, H. (2010) · Stem Cell Research · doi:10.1016/j.scr.2010.08.001 · Cited by 9
Investigation of the interleukin (IL)‐4/IL‐4 receptor system in promyelocytic leukaemia PLB‐985 cells during differentiation toward neutrophil‐like phenotype: mechanism involved in IL‐4‐induced SOCS3 protein expression
Ratthé, C., & Girard, D. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06886.x · Cited by 8
STAT5 activity in pancreatic β-cells
Dalgaard, L. T., Billestrup, N., & Nielsen, J. H. (2008) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.4.423 · Cited by 9
SOCS‐1/3 participation in FGF‐2 signaling to modulate RANK ligand expression in paget's disease of bone
Sundaram, K., Senn, J. J., & Reddy, S. V. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24554 · Cited by 8
Increased copy number of SOCS2 gene in Chinese gamecocks
Bi, H., Yi, G., & Yang, N. (2016) · Poultry Science · doi:10.3382/ps/pew391 · Cited by 8
Novel Interaction Between Nuclear Coactivator CBP and the Protein Inhibitor of Activated Stat1 (PIAS1)
Yin, X., Warner, D. R., Roberts, E. A., Pisano, M. M., & Greene, R. M. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.321 · Cited by 8
Increased SH2-Bβ content and membrane association in transgenic mice overexpressing GH
Miquet, J. G., Sotelo, A. I., Bartke, A., & Turyn, D. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05943 · Cited by 8
Antimigratory effect of pyrazole derivatives through the induction of STAT1 phosphorylation in A549 cancer cells
Demir, Y. D. Ş., Özdemir, A., Özdemir, R. G., Cevher, S. C., Çalışkan, B., & Ark, M. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab022 · Cited by 7
A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress
Papanikolaou, N. A., Tillinger, A., Liu, X., Papavassiliou, A. G., & Sabban, E. L. (2014) · BMC Systems Biology · doi:10.1186/s12918-014-0100-8 · Cited by 7
Lipid Metabolism in Tumor-Associated Fibroblasts
Li, H., & Wan, J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6785-2_8 · Cited by 5
SOCS3 Modulates Interleukin-6R Signaling Preference in Dermal Fibroblasts
Luckett‐Chastain, L. R., Ihnat, M. A., Mickle, B. M., & Gallucci, R. M. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0086 · Cited by 5
γ Chain transducing element: A shared pathway between endocrine and immune system
Vigliano, I., Fusco, A., Palamaro, L., Aloj, G., Cirillo, E., Salerno, M. C., & Pignata, C. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.03.006 · Cited by 4
The Role of Chemokines in Inflammatory Skin Diseases
Girolomoni, G., Pastore, S., Cavani, A., & Albanesi, C. (2004) · Springer eBooks · doi:10.1007/978-3-662-05397-3_11 · Cited by 4

Authors: Greenhalgh, C. J., & Hilton, D. J.
Affiliations: Walter and Eliza Hall Institute of Medical Research (AU)
Corresponding author: Greenhalgh, Christopher J
ORCID: Hilton, Douglas J
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2001-09-01
Volume: 70
Issue: 3
Pages: 348-356
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.70.3.348
OpenAlex: W2107469094
Cited by: 258
References: 93
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 11 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 11 · 2012: 13
FWCI: 10.00
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Anti-Cancer Council of Victoria, Melbourne, Australia
National Health and Medical Research Council, Canberra, Australia
National Institutes of Health (CA-22556)
Australian Federal Government Cooperative Research Centers Program
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: cytokine signaling, negative regulation, suppressor of cytokine signaling, STAT proteins, negative feedback loop, signal attenuation, protein phosphatase, transcriptional repression, DNA-binding activity
MeSH terms: Suppressor of Cytokine Signaling 1 Protein, Suppressor of Cytokine Signaling 3 Protein, Animals, Carrier Proteins, DNA-Binding Proteins, Models, Biological, Proteins, Repressor Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Cytokines, Protein Tyrosine Phosphatases, Intracellular Signaling Peptides and Proteins, Suppressor of Cytokine Signaling Proteins, Protein Inhibitors of Activated STAT, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Negative regulation of cytokine signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks