The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro
Abstract
DC-SIGN is a C-type lectin, highly expressed on the surface ofimmature dendritic cells (DCs), that mediates efficient infection of Tcells in trans by its ability to bind HIV-1, HIV-2, and SIV. Inaddition, the ability of DC-SIGN to bind adhesion molecules on surfacesof naïve T cells and endothelium also suggests its involvementin T-cell activation and DC trafficking. To gain further insights intothe range of expression and potential functions of DC-SIGN, weperformed a detailed analysis of DC-SIGN expression in adult and fetaltissues and also analyzed its regulated expression on cultured DCs andmacrophages. First, we show that DC-SIGN expression is restricted tosubsets of immature DCs in tissues and on specialized macrophages inthe placenta and lung. There were no overt differences between DC-SIGNexpression in adult and fetal tissues except that DC-SIGN expression inalveolar macrophages was only present after birth. Similarly, intissues, DC-SIGN was observed primarily on immature (CD83-negative)DCs. Secondly, in the peripheral blood, we found expression of DC-SIGNon a small subset of BDCA-2+ plasmacytoid DC precursors (pDC2),concordant with our finding of large numbers of DC-SIGN-positive cellsin allergic nasal polyps (previously shown to be infiltrated by DC2). Triple-label confocal microscopy indicated that DC-SIGN was colocalizedwith BDCA-2 and CD123 on DCs in nasal polyp tissue. Consistent withthis finding is our observation that DC-SIGN can be up-regulated onmonocyte-derived macrophages upon exposure to the Th2 cytokine, IL-13. In summary, our data demonstrate the relevant populations of DC andmacrophages that express DC-SIGN in vivo where it may impact theefficiency of virus infection and indicate that DC-SIGN expression maybe involved in the Th2 axis of immunity.
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Cites
Immunobiology of Dendritic Cells
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DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
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Cited by
Pathology and Pathogenesis of Severe Acute Respiratory Syndrome
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Self- and nonself-recognition by C-type lectins on dendritic cells
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DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2
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Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive Phenotype
Gustafsson, C., Mjösberg, J., Matussek, A., Geffers, R., Matthiesen, L., Berg, G., Sharma, S., Buer, J., & Ernerudh, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002078 · Cited by 373
Metadata
- Authors
- Soilleux, E. J., Morris, L. S., Leslie, G., Chehimi, J., Luo, Q., Levroney, E., Trowsdale, J., Montaner, L. J., Doms, R. W., Weissman, D., Coleman, N., & Lee, B.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-03-01
- Volume
- 71
- Issue
- 3
- Pages
- 445-457
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2145508988
- Cited by
- 458
- References
- 34
- FWCI
- 11.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Soilleux, E. J., Morris, L. S., Leslie, G., Chehimi, J., Luo, Q., Levroney, E., Trowsdale, J., Montaner, L. J., Doms, R. W., Weissman, D., Coleman, N., & Lee, B. (2002). Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.71.3.445
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
