The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Abstract
It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (T H 1) or T H 2 cells. Human monocyte (pDC1)–derived dendritic cells (DC1) were found to induce T H 1 differentiation, whereas dendritic cells (DC2) derived from CD4 + CD3 – CD11c – plasmacytoid cells (pDC2) induced T H 2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The T H 2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-γ. Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged T H 1 or T H 2 responses by regulating survival of the appropriate dendritic cell subset.
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Cites
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Wu, L., Li, C. L., & Shortman, K. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.903 · Cited by 400
Cited by
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293
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Metadata
- Authors
- Rissoan, M.-C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., Malefyt, R. D. W., & Liu, Y.-J.
- Venue
- Science
- Published
- 1999-02-19
- Volume
- 283
- Issue
- 5405
- Pages
- 1183-1186
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2116716017
- Cited by
- 1,846
- References
- 2
- FWCI
- 65.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rissoan, M.-C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., Malefyt, R. D. W., & Liu, Y.-J. (1999). Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation. Science. https://doi.org/10.1126/science.283.5405.1183
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