Adverse psychiatric effects of non-psychotropic medications
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Summary Patients presenting to psychiatrists frequently have comorbid medical conditions for which they are receiving treatment. A range of medications used for treatment of these conditions can have adverse effects resembling psychiatric symptoms. This article presents the results of our review of the literature on psychiatric adverse effects of various non-psychotropic medications, and discusses the mechanisms of such effects, their assessment and management. Among the commonly prescribed drugs found to have psychiatric adverse effects are corticosteroids, anti-Parkinsonian drugs, anti-epileptics, antiretrovirals, antibiotics, anticancer drugs, analgesics, drugs targeting endocrine and cardiovascular disorders, immunosuppressants, skeletal muscle relaxants and bronchodilators. Some adverse effects are predictable and dose dependent, whereas others are rare and idiosyncratic, and psychiatrists need to be aware of them for accurate diagnosis and appropriate treatment.
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Some medications for physical disorders might predispose to suicide.
“Literature suggests that some medications for physical disorders might predispose to suicide (65, 66).”
From Using Administrative Data to Predict Suicide After Psychiatric Hospitalization in the Veterans Health Administration System (2020) · cites this paper as [66]
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Research works printed but not linked: 1
- Sidhu KS, Balon R (2008) Watch for nonpsychotropics causing psychiatric side effects. Current Psychiatry, 7(4): 61-4, 68-74.
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Kessler, R. C., Bauer, M. S., Bishop, T. M., Demler, O. V., Dobscha, S. K., Gildea, S. M., Goulet, J. L., Karras, E., Kreyenbuhl, J., Landes, S. J., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00390 · Cited by 52 · see citing works
- Authors
- Gupta, A., & Chadda, R. K.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Corresponding author
- Chadda, Rakesh K.
- Venue
- BJPsych Advances
- Publisher
- Royal College of Psychiatrists
- Published
- 2016-09
- Volume
- 22
- Issue
- 5
- Pages
- 325-334
- ISSN
- 2056-4678 (ISSN-L)
- 2056-4686
- OpenAlex
- W2508921315
- Cited by
- 16
- References
- 43
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BJPsych Advances (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- drug-induced psychiatric adverse effects, comorbidities, corticosteroids, antiparkinsonian drugs, antiepileptic drugs, antiretroviral drugs, antibiotics, anticancer agents, analgesics, immunosuppressants, skeletal muscle relaxants, bronchodilators, dose-dependent adverse effects
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