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Cited by 185Tuberculosis Research and EpidemiologyMedication Adherence and ComplianceMental Health Treatment and Access

Psychiatric Morbidity and Other Factors Affecting Treatment Adherence in Pulmonary Tuberculosis Patients

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Pachi, Argiro, Bratis, Dionisios, Moussas, Georgios, Tselebis, Athanasios·2013·Tuberculosis Research and Treatment
DOI 10.1155/2013/489865PMC PMC3649695
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Abstract

As the overall prevalence of TB remains high among certain population groups, there is growing awareness of psychiatric comorbidity, especially depression and its role in the outcome of the disease. The paper attempts a holistic approach to the effects of psychiatric comorbidity to the natural history of tuberculosis. In order to investigate factors associated with medication nonadherence among patients suffering from tuberculosis, with emphasis on psychopathology as a major barrier to treatment adherence, we performed a systematic review of the literature on epidemiological data and past medical reviews from an historical perspective, followed by theoretical considerations upon the relationship between psychiatric disorders and tuberculosis. Studies reporting high prevalence rates of psychiatric comorbidity, especially depression, as well as specific psychological reactions and disease perceptions and reviews indicating psychiatric complications as adverse effects of anti-TB medication were included. In sum, data concerning factors affecting medication nonadherence among TB patients suggested that better management of comorbid conditions, especially depression, could improve the adherence rates, serving as a framework for the effective control of tuberculosis, but further studies are necessary to identify the optimal way to address such issues among these patients.

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  • Depression and anxiety are linked to delayed diagnosis, missed doses, treatment interruption, and poorer microbiological outcomes.

    “depression and anxiety in particular have been linked to delayed diagnosis, missed doses, treatment interruption, and poorer microbiological outcomes [10,11,12].”

    From Psychosocial Interventions for Improving Treatment Adherence in Tuberculosis Patients: A Scoping Review of Evidence-Based Approaches. (2026) · cites this paper as [12]

    The Introduction and Discussion link psychiatric comorbidity, particularly depression, to poorer adherence to tuberculosis medication; the Discussion also describes treatment interruption as a form of nonadherence. The paper does not establish the claimed links to delayed diagnosis or specifically poorer microbiological outcomes, and its adherence discussion does not separately document missed doses for both depression and anxiety. The indexed passages have no page numbers. (LLM, conf=0.86)

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  • Pre-existing or comorbid mental disorders may compromise help-seeking and adherence by reducing motivation, impairing concentration and memory for daily medication routines, increasing risky behaviors such as alcohol or drug use, and weakening the patient-provider relationship.

    “pre-existing or comorbid mental disorders may compromise help-seeking and adherence by reducing motivation, impairing concentration and memory for daily medication routines, increasing risky behaviors such as alcohol or drug use, and weakening the patient–provider relationship”

    From Psychosocial Interventions for Improving Treatment Adherence in Tuberculosis Patients: A Scoping Review of Evidence-Based Approaches. (2026) · cites this paper as [12]

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Cited by

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Authors
Pachi, A., Bratis, D., Moussas, G., & Tselebis, A.
Affiliations
Sotiria General Hospital (GR)
Corresponding author
Tselebis, Athanasios
ORCID
Venue
Tuberculosis Research and Treatment
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-37
ISSN
  • 2090-150X (ISSN-L)
  • 2090-1518
DOI
10.1155/2013/489865
PMC
PMC3649695
OpenAlex
W1995320119
Cited by
185
References
11
Citations by year
2026: 3 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 21 · 2021: 25 · 2020: 20 · 2019: 18 · 2018: 10 · 2017: 10 · 2016: 12 · 2015: 6 · 2014: 8
FWCI
6.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Tuberculosis Research and Treatment (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
pulmonary tuberculosis, psychiatric comorbidity, depression, medication non-adherence, medication adherence, psychopathology, illness perception

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