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II. A Randomised Controlled Trial of Prophylactic Neuroleptic Treatment
Abstract
Out of 253 patients fulfilling criteria for a first episode of schizophrenic illness, 120 entered a randomised placebo-controlled trial of maintenance neuroleptic medication on discharge; they were followed to relapse or loss to follow-up, for two years or to the end of the study. Of those on active medication, 46% relapsed, as did 62% of those on placebo; the most important determinant of relapse was duration of illness prior to starting neuroleptic medication. This finding might be because extended duration of symptoms before admission is more likely to be present in illnesses which in any case will have poor prognosis, or because susceptibility to relapse is reduced by early institution of treatment. The study provides no data on which a decision between these alternative explanations can be based.
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Citations
Cited by
Robinson, D., Woerner, M. G., Alvir, J. M. J., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.241 · Cited by 1,327
EPPIC: An Evolving System of Early Detection and Optimal Management
McGorry, P. D., Edwards, J., Mihalopoulos, C., Harrigan, S. M., & Jackson, H. J. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.305 · Cited by 937
Leucht, S., Tardy, M., Komossa, K., Heres, S., Kissling, W., Salanti, G., & Davis, J. M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60239-6 · Cited by 931
Neuroleptics and the Natural Course of Schizophrenia
Wyatt, R. J. (1991) · Schizophrenia Bulletin · doi:10.1093/schbul/17.2.325 · Cited by 787
Barnes, T. R., Drake, R., Paton, C., Cooper, S. J., Deakin, B., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 606
Metadata
- Authors
- Crow, T. J., MacMillan, J. F., Johnson, A. L., & Johnstone, E. C.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1986-02
- Volume
- 148
- Issue
- 2
- Pages
- 120-127
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2128674065
- Cited by
- 491
- References
- 0
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Crow, T. J., MacMillan, J. F., Johnson, A. L., & Johnstone, E. C. (1986). II. A Randomised Controlled Trial of Prophylactic Neuroleptic Treatment. British Journal of Psychiatry. https://doi.org/10.1192/bjp.148.2.120
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
