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The Clinical Efficacy of Citalopram in Treatment of Emotional Disturbances in Dementia Disorders a Nordic Multicentre Study
Abstract
In this multicentre study, the clinical efficacy of citalopram was investigated in 98 patients with moderate AD/SDAT or VD using a combined double-blind and open technique with placebo and citalopram. Analyses were made for each diagnosis after four weeks of double-blind treatment. Patients with AD/SDAT treated with citalopram showed a significant improvement in emotional bluntness, confusion, irritability, anxiety, fear/panic, depressed mood and restlessness. Those improvements were not found after treatment with placebo. There were no significant improvements in patients with VD. No improvements were recorded in motor or cognitive impairment. Citalopram provoked few and comparatively mild side-effects. None of the changes observed during the double-blind withdrawal period were identified as withdrawal symptoms or rebound phenomena.
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Citalopram has been suggested as an alternative to antipsychotic drugs for agitation and aggression in dementia.
“and has been suggested as an alternative to antipsychotic drugs for agitation and aggression in dementia13–16.”
From Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial (2014) · cites this paper as [13]
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Metadata
- Authors
- Nyth, A. L., & Gottfries, C. G.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Nyth, Anna Lena
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1990-12
- Volume
- 157
- Issue
- 6
- Pages
- 894-901
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2052496664
- Cited by
- 379
- References
- 2
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 11 · 2015: 2 · 2014: 13 · 2013: 5 · 2012: 9
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- citalopram, dementia, Alzheimer's disease, vascular dementia, emotional disturbance, depression, anxiety, irritability, selective serotonin reuptake inhibitors, antidepressant efficacy, adverse effects, withdrawal symptoms
- MeSH terms
- Affective Symptoms, Aged, Alzheimer Disease, Double-Blind Method, Female, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Male, Methoxyhydroxyphenylglycol, Neuropsychological Tests, Scandinavian and Nordic Countries, Dementia, Multi-Infarct, Citalopram
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