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Cited by 333

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Outcome of Bipolar Disorder on Long-Term Treatment with Lithium

O'Connell, Ralph A., Mayo, Julia A., Flatow, Leslie, Cuthbertson, Beverly, O'Brien, Barbara E.·1991·British Journal of Psychiatry
DOI 10.1192/bjp.159.1.123
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Abstract

The long-term treatment outcome of 248 bipolar patients in an out-patient lithium programme was assessed. Over half of the patients (138 or 56%) had no affective episodes in the year observed. Patients were divided into outcome groups according to GAS scores: the outcome for 40% of patients was good, for 41% fair, and for 19% poor. More frequent psychiatric admissions before starting lithium treatment was the best predictor of poor outcome, followed by a negative affective style in the family and lower social class. Current alcohol and drug abuse was associated with poor outcome. Although familial and psychosocial factors were significantly associated with outcome, the findings suggest there may be inherent differences in the pathophysiology of bipolar disorder reflected in an increased frequency of episodes which account for a large variance in lithium treatment outcome.

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Metadata

Authors
O'Connell, R. A., Mayo, J. A., Flatow, L., Cuthbertson, B., & O'Brien, B. E.
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
1991-07
Volume
159
Issue
1
Pages
123-129
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.159.1.123
OpenAlex
W2130261986
Cited by
333
References
1
FWCI
4.34
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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