Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works

Oxidative stress, inflammation, and cancer: How are they linked?

Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works

Bipolar Disorder

Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works

Oxidative stress and neurodegeneration: where are we now?

Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works

Lipid peroxidation: its mechanism, measurement, and significance

Halliwell, B. B., & Chirico, S. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.5.715s · Cited by 2,355 · see citing works

Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects

Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742 · see citing works

Bipolar disorder

Grande, I., Berk, M., Birmaher, B., & Vieta, E. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00241-x · Cited by 1,710 · see citing works

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609 · see citing works

So depression is an inflammatory disease, but where does the inflammation come from?

Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423 · see citing works

The glutamate homeostasis hypothesis of addiction

Kalivas, P. W. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2515 · Cited by 1,350 · see citing works

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works

NMDA-dependent superoxide production and neurotoxicity

Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183 · see citing works

Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178 · see citing works

Role of Pro-Inflammatory Cytokines Released from Microglia in Neurodegenerative Diseases

Smith, J. A., Das, A., Ray, S. K., & Banik, N. L. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.004 · Cited by 1,165 · see citing works

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

Moghaddam, B., & Javitt, D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.181 · Cited by 1,035 · see citing works

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.90 · Cited by 963 · see citing works

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

Hannestad, J., DellaGioia, N., & Bloch, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.132 · Cited by 914 · see citing works

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

Sanacora, G., Zarate, C. A., Krystal, J. H., & Manji, H. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2462 · Cited by 894 · see citing works

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894 · see citing works

TNF-α signalling and inflammation: interactions between old acquaintances

Zelová, H., & Hošek, J. (2013) · Inflammation Research · doi:10.1007/s00011-013-0633-0 · Cited by 857 · see citing works

The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine

Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794 · see citing works

The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders

Pacchiarotti, I., Bond, D. J., Baldessarini, R. J., Nolen, W. A., Grunze, H., Licht, R. W., Post, R. M., Berk, M., Goodwin, G. M., Sachs, G. S., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020185 · Cited by 770 · see citing works

Relapse and impairment in bipolar disorder

(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1635 · Cited by 762 · see citing works

Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments

Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

Mehta, A., Prabhakar, M., Kumar, P., Deshmukh, R. R., & Sharma, P. L. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.10.032 · Cited by 662 · see citing works

Increased Levels of Glutamate in Brains from Patients with Mood Disorders

Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works

Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies

Modabbernia, A., Taslimi, S., Brietzke, E., & Ashrafi, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.007 · Cited by 596 · see citing works

Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

Gawryluk, J. W., Wang, J.-F., Andreazza, A. C., Shao, L., & Young, L. T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000805 · Cited by 594 · see citing works

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works

Oxidative stress markers in bipolar disorder: A meta-analysis

Andreazza, A. C., Kauer-Sant'Anna, M., Frey, B. N., Bond, D. J., Kapczinski, F., Young, L. T., & Yatham, L. N. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.013 · Cited by 526 · see citing works

N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

Berk, M., Copolov, D. L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., & Bush, A. I. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.022 · Cited by 500 · see citing works

Molecular Evidence for Mitochondrial Dysfunction in Bipolar Disorder

Konradi, C. L., Eaton, M. E., MacDonald, M. L., Walsh, J. P., Benes, F. M., & Heckers, S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.300 · Cited by 499 · see citing works

Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems

Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486 · see citing works

Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates

Perera, T. D., Coplan, J. D., Lisanby, S. H., Lipira, C. M., Arif, M., Carpio, C., Spitzer, G., Santarelli, L., Scharf, B., Hen, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0237-07.2007 · Cited by 461 · see citing works

Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works

Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder

Kauer‐Sant’Anna, M., Kapczinski, F. P., Andreazza, A. C., Bond, D. J., Lam, R. W. M., Young, L. T., & Yatham, L. N. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009310 · Cited by 434 · see citing works

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients

Rao, J. S., Harry, G. J., Rapoport, S. I., & Kim, H. W. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.47 · Cited by 432 · see citing works

Frequency and Characteristics of Isolated Psychiatric Episodes in Anti– N -Methyl- d -Aspartate Receptor Encephalitis

Kayser, M. S., Titulaer, M. J., Gresa‐Arribas, N., & Dalmau, J. O. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3216 · Cited by 419 · see citing works

An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline

Uher, R., Tansey, K. E., Dew, T., Maier, W., Mors, O., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010094 · Cited by 418 · see citing works

Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder

Chiu, C.-T., Wang, Z., Hunsberger, J. G., & Chuang, D.-M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005512 · Cited by 404 · see citing works

Cytokines in bipolar disorder vs. healthy control subjects: A systematic review and meta-analysis

Munkholm, K., Braüner, J. V., Kessing, L. V., & Vinberg, M. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.018 · Cited by 402 · see citing works

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

Clay, H. B., Daws, S., & Konradi, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.007 · Cited by 399 · see citing works

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

Berk, M., Dean, O. M., Drexhage, H. A., McNeil, J. J., Moylan, S., O'Neil, A. E., Davey, C. G., Sanna, L., & Maes, M. H. J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-74 · Cited by 392 · see citing works

Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes

Cunha, A. B. M., Frey, B. N., Andreazza, A. C., Goi, J. D., Rosa, A. R., Gonçalves, C. A., Santin, A. M. P., & Kapczinski, F. P. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.085 · Cited by 391 · see citing works

Mitochondrial dysfunction in bipolar disorder

Kato, T., & Kato, N. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.020305.x · Cited by 381 · see citing works

An updated meta-analysis of oxidative stress markers in bipolar disorder

Brown, N. C., Andreazza, A. C., & Young, L. T. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.005 · Cited by 333 · see citing works

Outcome of Bipolar Disorder on Long-Term Treatment with Lithium

O’Connell, R. A., Mayo, J. A., Flatow, L., Cuthbertson, B. A., & O'Brien, B. E. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.159.1.123 · Cited by 332 · see citing works

Initiation of acute phase response and synthesis of cytokines

Koj, A. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(96)00048-8 · Cited by 330 · see citing works

Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder

Kuloglu, M., Ustundag, B., Atmaca, M., Canatan, H., Tezcan, A. E., & Cinkilinc, N. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.940 · Cited by 321 · see citing works

Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effects

Machado‐Vieira, R., Andreazza, A. C., Viale, C. I., Zanatto, V. C., Ceresér, V. H., Vargas, R. D. S., Kapczinski, F. P., Portela, L. V., Souza, D. O., Salvador, M. M., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.016 · Cited by 314 · see citing works

Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double‐blind, randomized, placebo‐controlled study

Nery, F. G., Monkul, E. S., Hatch, J. P., Fonseca, M., Zunta‐Soares, G. B., Frey, B. N., Bowden, C. L., & Soares, J. C. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.912 · Cited by 298 · see citing works

Interferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis

Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297 · see citing works

Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia

Wang, J., Shao, L., Sun, X., & Young, L. T. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00717.x · Cited by 270 · see citing works

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

Cataldo, A. M., McPhie, D. L., Lange, N. T., Punzell, S., Elmiligy, S., Ye, N. Z., Froimowitz, M. P., Hassinger, L. C., Menesale, E. B., Sargent, L. W., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.081068 · Cited by 269 · see citing works

The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder.

Drexhage, R. C., Knijff, E. M., Padmos, R. C., Heul-Nieuwenhuijzen, L. V. D., Beumer, W., Versnel, M. A., & Drexhage, H. A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.144 · Cited by 263 · see citing works

Clinical implications of a staging model for bipolar disorders

Kapczinski, F. P., Dias, V. V., Kauer‐Sant’Anna, M., Frey, B. N., Grassi‐Oliveira, R., Colom, F., & Berk, M. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.31 · Cited by 263 · see citing works

Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity

Hashimoto, R., Takei, N., Shimazu, K., Christ, L. A., Lu, B., & Chuang, D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00217-4 · Cited by 257 · see citing works

An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression

Zarate, C. A., Quiroz, J. A., Singh, J. B., Denicoff, K. D., Jesus, G. D., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.023 · Cited by 257 · see citing works

A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression

Zarate, C. A., Mathews, D., Ibrahim, L., Chaves, J. F., Marquardt, C., Ukoh, I., Jolkovsky, L., Brutsche, N. E., Smith, M. A., & Luckenbaugh, D. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.019 · Cited by 255 · see citing works

Effects of lithium and valproate on amphetamineinduced oxidative stress generation in an animal model of mania

Frey, B. N., Valvassori, S. S., Réus, G. Z., Martins, M. R., Petronilho, F. C., Bardini, K., Dal‐Pizzol, F., Kapczinski, F. P., & Quevedo, J. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0637 · Cited by 238 · see citing works

Peripheral biomarkers and illness activity in bipolar disorder

Kapczinski, F. P., Dal‐Pizzol, F., Teixeira, A. L., Magalhães, P. V. D. S., Kauer‐Sant’Anna, M., Klamt, F., Moreira, J. C. F., Pasquali, M. A. D. B., Fries, G. R., Quevedo, J., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.015 · Cited by 236 · see citing works

Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy

Kato, T., Takahashi, S., Shioiri, T., & Inubushi, T. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90097-4 · Cited by 227 · see citing works

Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis.

Gigante, A. D., Bond, D. J., Lafer, B., Lam, R. W., Young, L. T., & Yatham, L. N. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01033.x · Cited by 226 · see citing works

Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy

Kato, T., Takahashi, S., Shioiri, T., Murashita, J., Hamakawa, H., & Inubushi, T. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90116-3 · Cited by 223 · see citing works

Decreased Plasma Brain Derived Neurotrophic Factor Levels in Unmedicated Bipolar Patients During Manic Episode

Machado‐Vieira, R., Dietrich, M. O., Leke, R., Cereser, V. H., Zanatto, V. C., Kapczinski, F. P., Souza, D. O., Portela, L. V., & Gentil, V. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.070 · Cited by 223 · see citing works

Increased Anterior Cingulate/Medial Prefrontal Cortical Glutamate and Creatine in Bipolar Depression

Frye, M. A., Watzl, J., Banakar, S., O’Neill, J., Mintz, J., Davanzo, P. A., Fischer, J., Chirichigno, J. W., Ventura, J., Elman, S., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301387 · Cited by 221 · see citing works

Chronic Treatment with Mood Stabilizers Lithium and Valproate Prevents Excitotoxicity by Inhibiting Oxidative Stress in Rat Cerebral Cortical Cells

Shao, L., Young, L. T., & Wang, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.052 · Cited by 218 · see citing works

Acute phase proteins in major depression

Berk, M., Wadee, A. A., Kuschke, R. H., & O’Neill-Kerr, A. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00139-6 · Cited by 215 · see citing works

Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

Miyaoka, T., Wake, R., Furuya, M., Liaury, K., Ieda, M., Kawakami, K., Tsuchie, K., Taki, M., Ishihara, K., Araki, T., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.002 · Cited by 212 · see citing works

Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients

Kim, H., Rapoport, S. I., & Rao, J. S. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.010 · Cited by 210 · see citing works

3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder

Andreazza, A. C., Kapczinski, F. P., Kauer‐Sant’Anna, M., Walz, J. C., Bond, D. J., Gonçalves, C. A., Young, L. T., & Yatham, L. N. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0935 · Cited by 199 · see citing works

Atypical Antipsychotics in the Treatment of Mania: A Meta-Analysis of Randomized, Placebo-Controlled Trials

Perlis, R. H., Welge, J. A., Vornik, L. A., Hirschfeld, R. M. A., & Keck, P. E. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0401 · Cited by 196 · see citing works

Randomized Proof of Concept Trial of GLYX-13, an N-Methyl-D-Aspartate Receptor Glycine Site Partial Agonist, in Major Depressive Disorder Nonresponsive to a Previous Antidepressant Agent

PRESKORN, S., MACALUSO, M., MEHRA, D. V., ZAMMIT, G., MOSKAL, J. R., & BURCH, R. M. (2015) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000462606.17725.93 · Cited by 193 · see citing works

Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Kunz, M., Ceresér, K. M. M., Goi, P. D., Fries, G. R., Teixeira, A. L., Fernandes, B. S., Belmonte-de-Abreu, P. S., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Gama, C. S. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000300010 · Cited by 189 · see citing works

Glutamate Levels in the Associative Striatum Before and After 4 Weeks of Antipsychotic Treatment in First-Episode Psychosis

de la Fuente‐Sandoval, C., León-Ortíz, P., Azcárraga, M., Stephano, S., Favila, R., Díaz-Galvis, L., Alvarado-Alanis, P., Ramírez‐Bermúdez, J., & Graff‐Guerrero, A. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.289 · Cited by 181 · see citing works

Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients

Palomino, A., Vallejo‐Illarramendi, A., González-Pinto, A. M., Aldama, A., González‐Gómez, C., Mosquera, F., González-García, G., & Matute, C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.028 · Cited by 180 · see citing works

Riluzole in the Treatment of Mood and Anxiety Disorders

Pittenger, C., Coric, V., Banasr, M., Bloch, M., Krystal, J. H., & Sanacora, G. (2008) · CNS Drugs · doi:10.2165/00023210-200822090-00004 · Cited by 177 · see citing works

Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder

Clinton, S. M., & Meador‐Woodruff, J. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300451 · Cited by 177 · see citing works

Mitochondrially Mediated Plasticity in the Pathophysiology and Treatment of Bipolar Disorder

Quiroz, J. A., Gray, N. A., Kato, T., & Manji, H. K. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301671 · Cited by 170 · see citing works

Oxidative stress in early stage Bipolar Disorder and the association with response to lithium

de Sousa, R. T., Zarate, C. A., Zanetti, M. V., Costa, A. C., Talib, L. L., Gattaz, W. F., & Machado-Vieira, R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.11.011 · Cited by 169 · see citing works

Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder

Friedman, S. D., Dager, S. R., Parow, A. M., Hirashima, F., Demopulos, C. M., Stoll, A. L., Lyoo, I. K., Dünner, D. L., & Renshaw, P. F. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.012 · Cited by 165 · see citing works

Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia.

Hope, S., Dieset, I., Agartz, I., Steen, N. E., Ueland, T., Melle, I., Aukrust, P., & Andreassen, O. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.08.003 · Cited by 164 · see citing works

Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder

McCullumsmith, R. E., Kristiansen, L. V., Beneyto, M., Scarr, E., Dean, B., & Meador‐Woodruff, J. H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.011 · Cited by 157 · see citing works

Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness

Che, Y., Wang, J.-F., Shao, L., & Young, L. T. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090083 · Cited by 155 · see citing works

The Clinical Implications Of Cognitive Impairment and Allostatic Load in Bipolar Disorder

Vieta, E., Popović, D., Rosa, A. R., Solé, B., Grande, I., Frey, B. N., Martínez‐Arán, A., Sánchez‐Moreno, J., Balanzá‐Martínez, V., Tabarés‐Seisdedos, R., et al. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2011.11.007 · Cited by 147 · see citing works

Lithium increases plasma brain-derived neurotrophic factor in acute bipolar mania: A preliminary 4-week study

SOUSA, R. T. D., van de Bilt, M. T., Diniz, B. S., Ladeira, R. B., Portela, L. V., Souza, D. O., Forlenza, O. V., Gattaz, W. F., & Machado‐Vieira, R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.054 · Cited by 145 · see citing works

Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis

Gigante, A. D., Young, L. T., Yatham, L. N., Andreazza, A. C., Nery, F. G., Grinberg, L. T., Heinsen, H., & Lafer, B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571000146x · Cited by 143 · see citing works

Minocycline: Therapeutic Potential in Psychiatry

Dean, O. M., Data-Franco, J., Giorlando, F., & Berk, M. (2012) · CNS Drugs · doi:10.2165/11632000-000000000-00000 · Cited by 131 · see citing works

A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: Efficacy and tolerability

McGirr, A., Berlim, M. T., Bond, D. J., Neufeld, N. H., Chan, P. Y., Yatham, L. N., & Lam, R. W. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.01.003 · Cited by 127 · see citing works

Effects of lithium therapy on Na+–K+-ATPase activity and lipid peroxidation in bipolar disorder

Banerjee, U., Dasgupta, A., Rout, J. K., & Singh, O. P. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.006 · Cited by 124 · see citing works

Serum brain-derived neurotrophic factor in bipolar and unipolar depression: A potential adjunctive tool for differential diagnosis

Fernandes, B. S., Gama, C. S., Kauer‐Sant’Anna, M., Lobato, M. I. R., Belmonte-de-Abreu, P. S., & Kapczinski, F. P. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.04.010 · Cited by 124 · see citing works

Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass

Davis, J., Maes, M., Andreazza, A., McGrath, J. J., Tye, S. J., & Berk, M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.139 · Cited by 123 · see citing works

Markers of Glutamate Synaptic Transmission and Plasticity Are Increased in the Anterior Cingulate Cortex in Bipolar Disorder

Eastwood, S. L., & Harrison, P. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.004 · Cited by 122 · see citing works

Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients

Kim, H., Рапопорт, С. И., & Rao, J. S. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.137 · Cited by 121 · see citing works

Effects of lithium on oxidative stress parameters in healthy subjects

Machado‐Vieira, R. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.732 · Cited by 121 · see citing works

Mitochondrial Dysfunction as the Molecular Basis of Bipolar Disorder

Kato, T. (2007) · CNS Drugs · doi:10.2165/00023210-200721010-00001 · Cited by 113 · see citing works

Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication‐free individuals with bipolar disorder: an in vivo1H MRS study

Frey, B. N., Stanley, J. A., Nery, F. G., Monkul, E. S., Nicoletti, M., Chen, H., Hatch, J. P., Caetano, S. C., Ortíz, O., Kapczinski, F. P., et al. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00454.x · Cited by 113 · see citing works

Epigenetic modulation of BDNF gene: Differences in DNA methylation between unipolar and bipolar patients

Dell׳Osso, B., D׳Addario, C., Carlotta Palazzo, M., Benatti, B., Camuri, G., Galimberti, D., Fenoglio, C., Scarpini, E., Di Francesco, A., Maccarrone, M., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.020 · Cited by 112 · see citing works

Inhibitory Effects of Ketamine on Lipopolysaccharide-Induced Microglial Activation

Chang, Y. F., Lee, J.-J., Hsieh, C., Hsiao, G., Chou, D., & Sheu, J. (2009) · Mediators of Inflammation · doi:10.1155/2009/705379 · Cited by 108 · see citing works

Inflammation, mitochondria, and the inhibition of adult neurogenesis

Voloboueva, L. A., & Giffard, R. G. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22768 · Cited by 106 · see citing works

Possible antipsychotic effects of minocycline in patients with schizophrenia

Miyaoka, T., Yasukawa, R., YASUDA, H., Hayashida, M., Inagaki, T., & Horiguchi, J. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.013 · Cited by 105 · see citing works

Putative neuroprotective agents in neuropsychiatric disorders

Dodd, S., Maes, M. H. J., Anderson, G., Dean, O. M., Moylan, S., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.007 · Cited by 105 · see citing works

Serological observations in patients suffering from acute manic episodes

Wadee, A. A., Kuschke, R. H., Wood, L. A., Berk, M., Ichim, L., & Maes, M. H. J. (2002) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.390 · Cited by 104 · see citing works

Impact of antipsychotics on cytokine production in-vitro

Himmerich, H., Schönherr, J., Fulda, S., Sheldrick, A. J., Bauer, K., & Sack, U. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.04.009 · Cited by 104 · see citing works

Staging bipolar disorder: clinical, biochemical, and functional correlates

Grande, I., Magalhães, P. V. D. S., Chendo, I., Stertz, L., Panizzutti, B., Colpo, G. D., Rosa, A. R., Gama, C. S., Kapczinski, F. P., & Vieta, E. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12268 · Cited by 99 · see citing works

The effects of lithium on ex vivo cytokine production

Rapaport, M. H., & Manji, H. K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01144-1 · Cited by 98 · see citing works

From neuroprogression to neuroprotection: implications for clinical care.

Berk, M., Conus, P., Kapczinski, F. P., Andreazza, A. C., Yücel, M., Wood, S. J., Pantelis, C., Malhi, G. S., Dodd, S., Bechdolf, A., et al. (2010) · PubMed · Cited by 96 · see citing works

Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

Berk, M., Dean, O. M., Cotton, S., Gama, C. S., Kapczinski, F. P., Fernandes, B. S., Kohlmann, K., Jeavons, S., Hewitt, K., Moss, K., et al. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-91 · Cited by 96 · see citing works

Reduced antioxidant defense systems in schizophrenia and bipolar I disorder

Raffa, M., Barhoumi, S., Atig, F., Fendri, C., Kerkeni, A., & Mechri, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.013 · Cited by 95 · see citing works

Mitochondrial Mutations and Polymorphisms in Psychiatric Disorders

Sequeira, A., Martin, M. V., Rollins, B. L., Moon, E. A., Bunney, W. E., Macciardi, F. M., Lupoli, S., Smith, E. N., Kelsoe, J. R., Magnan, C. N., et al. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00103 · Cited by 93 · see citing works

Single ketamine infusion in bipolar depression resistant to antidepressants: are neurotrophins involved?

RYBAKOWSKI, J. K., Permoda‐Osip, A., Skibińska, M., Adamski, R., & Bartkowska‐Śniatkowska, A. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2271 · Cited by 92 · see citing works

Novel glutamatergic agents for major depressive disorder and bipolar disorder

Machado-Vieira, R., Ibrahim, L., Henter, I. D., & Zarate, C. A. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.09.010 · Cited by 92 · see citing works

Altered plasma glutathione levels in bipolar disorder indicates higher oxidative stress; a possible risk factor for illness onset despite normal brain-derived neurotrophic factor (BDNF) levels

Rosa, A. R., Singh, N., Whitaker, E., de Brito, M., Lewis, A. M., Vieta, E., Churchill, G. C., Geddes, J. R., & Goodwin, G. M. (2014) · Psychological Medicine · doi:10.1017/s0033291714000014 · Cited by 91 · see citing works

Immune dysregulation and autoimmunity in bipolar disorder: Synthesis of the evidence and its clinical application

Rege, S., & Hodgkinson, S. J. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413499077 · Cited by 90 · see citing works

Effects of mood stabilizers on DNA damage in an animal model of mania

Andreazza, A. C., Kauer‐Sant’Anna, M., Frey, B. N., Stertz, L., Zanotto, C., Ribeiro, L. C., Giasson, K., Valvassori, S. S., Réus, G. Z., Salvador, M. M., et al. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0849 · Cited by 84 · see citing works

Case–case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes

Curtis, D., Vine, A. E., McQuillin, A., Bass, N. J., Pereira, A. C., Kandaswamy, R., Lawrence, J., Anjorin, A., Choudhury, K., Datta, S. R., et al. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283413382 · Cited by 83 · see citing works

The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment

Andreazza, A. C., & Young, L. T. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000096 · Cited by 80 · see citing works

Illness duration and total brain gray matter in bipolar disorder: Evidence for neurodegeneration?

Frey, B. N., Zunta-Soares, G. B., Caetano, S. C., Nicoletti, M. A., Hatch, J. P., Brambilla, P., Mallinger, A. G., & Soares, J. C. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.04.015 · Cited by 79 · see citing works

Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development

Nierenberg, A. A., Kansky, C., Brennan, B. P., Shelton, R. C., Perlis, R. H., & Iosifescu, D. V. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412449303 · Cited by 76 · see citing works

Peripheral oxidative damage in early-stage mood disorders: a nested population-based case-control study

Magalhães, P. V. D. S., Jansen, K., Pinheiro, R. T., Colpo, G. D., da Motta, L. L., Klamt, F., da Silva, R. A., & Kapczinski, F. P. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001532 · Cited by 75 · see citing works

Structural Abnormalities in Bipolar Euthymia: A Multicontrast Molecular Diffusion Imaging Study

Canales-Rodríguez, E. J., Pomarol-Clotet, E., Radua, J., Sarró, S., Alonso-Lana, S., Del Mar Bonnín, C., Goikolea, J. M., Maristany, T., García-Álvarez, R., Vieta, E., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.027 · Cited by 72 · see citing works

Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2×2 clinical trial

Savitz, J. B., Preskorn, S., Teague, T. K., Drevets, D. A., Yates, W. R., & Drevets, W. (2012) · BMJ Open · doi:10.1136/bmjopen-2011-000643 · Cited by 72 · see citing works

Decreased levels of plasma glutamate in patients with first-episode schizophrenia and bipolar disorder

Palomino, A., González-Pinto, A. M., Aldama, A., González-Gómez, C., Mosquera, F., González-García, G., & Matute, C. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.06.012 · Cited by 71 · see citing works

Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double‐blind, randomized, placebo‐controlled trial

Anand, A., Gunn, A. D., Barkay, G., Karne, H. S., Nürnberger, J. I., Mathew, S. J., & Ghosh, S. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00971.x · Cited by 66 · see citing works

The specificity of platelet glutamate receptor supersensitivity in psychotic disorders

Berk, M., Plein, H., & Belsham, B. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)80002-8 · Cited by 64 · see citing works

Glutamate-mediated calcium signaling: A potential target for lithium action

Sourial-Bassillious, N., Rydelius, P., Aperia, A. C., & Aizman, O. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.013 · Cited by 64 · see citing works

Increase in brain-derived neurotrophic factor in first episode psychotic patients after treatment with atypical antipsychotics

González-Pinto, A. M., Mosquera, F., Palomino, A., Alberich, S., Gutiérrez, A., Haidar, K., Vega, P., Barbeito, S., Jauregi, A. O., & Matute, C. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328338bc5a · Cited by 63 · see citing works

Analyzing the Effects of Psychotropic Drugs on Metabolite Profiles in Rat Brain Using¹H NMR Spectroscopy

McLoughlin, G. A., Ma, D., Tsang, T. M., Jones, D. N. C., Cilia, J., Hill, M. D., Robbins, M. J., Benzel, I. M., Maycox, P. R., Holmes, E., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr800892u · Cited by 63 · see citing works

Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells☆

Park, S. W., Lee, J. G., Ha, E. K., Choi, S. M., Cho, H. Y., Seo, M. K., & Kim, Y. H. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.12.012 · Cited by 60 · see citing works

The Level of Serum Brain-Derived Neurotrophic Factor Is Associated With the Therapeutic Efficacy of Modified Electroconvulsive Therapy in Chinese Patients With Depression

Hu, Y., Yu, X., Yang, F., Si, T., Wang, W., Tan, Y., Zhou, D., Wang, H., & Chen, D. (2010) · Journal of Ect · doi:10.1097/yct.0b013e3181c18bbf · Cited by 60 · see citing works

Possible antidepressant effect of minocycline

Levine, J. S., Cholestoy, A., & Zimmerman, J. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.4.582b · Cited by 60 · see citing works

Serum Brain-Derived Neurotrophic Factor in Euthymic Bipolar Patients on Prophylactic Lithium Therapy

Suwalska, A., Sobieska, M., & RYBAKOWSKI, J. K. (2010) · Neuropsychobiology · doi:10.1159/000319949 · Cited by 58 · see citing works

A preliminary investigation on the efficacy of <i>N</i> -acetyl cysteine for mania or hypomania

Vieira da Silva Magalhães, P., Dean, O. M., Bush, A. I., Copolov, D. L., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., & Berk, M. (2013) · Australian &amp; New Zealand Journal of Psychiatry · doi:10.1177/0004867413481631 · Cited by 58 · see citing works

Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells

Lee, J. G., Cho, H. Y., Park, S. W., Seo, M. K., & Kim, Y. H. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.013 · Cited by 56 · see citing works

Evidence for an association between tumor necrosis factor-alpha levels and lithium response

Gülöksüz, S., Altınbaş, K., Çetin, E. A., Kenis, G., Gazioğlu, S. B., Deniz, G., Oral, E., & van Os, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.044 · Cited by 55 · see citing works

Increased serum neurotrophin-4/5 levels in bipolar disorder

Walz, J. C., Magalhães, P. V. D. S., Giglio, L. M. F., Cunha, A. B. M., Stertz, L., Fries, G. R., Andreazza, A. C., & Kapczinski, F. P. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.10.005 · Cited by 54 · see citing works

Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 induction

Leng, Y., Fessler, E., & Chuang, D. M. (2012) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000429 · Cited by 53 · see citing works

In vivo glutathione levels in young persons with bipolar disorder: A magnetic resonance spectroscopy study

Lagopoulos, J., Hermens, D. F., Tobias‐Webb, J., Duffy, S. L., Naismith, S. L., White, D., Scott, E. M., & Hickie, I. B. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.12.006 · Cited by 51 · see citing works

Antipsychotic Medication and Oxidative Cell Stress

Lepping, P., Delieu, J., Mellor, R., Williams, J. H. H., Hudson, P. R., & Hunter-Lavin, C. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09r05268yel · Cited by 49 · see citing works

Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia

Gigante, A. D., Andreazza, A. C., Lafer, B., Yatham, L. N., Beasley, C. L., & Young, L. T. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.09.064 · Cited by 48 · see citing works

Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton magnetic resonance spectroscopy

Shibuya‐Tayoshi, S., Tayoshi, S., Sumitani, S., Ueno, S., Harada, M., & Ohmori, T. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.015 · Cited by 47 · see citing works

The role of brain‐derived neurotrophic factor ( BDNF ) Val66Met genetic polymorphism in bipolar disorder: a case–control study, comorbidities, and meta‐analysis of 16,786 subjects

González‐Castro, T. B., Nicolini, H., Lanzagorta, N., López‐Narváez, M. L., Genis, A. D., García, S. P., & Tovilla‐Zárate, C. A. (2014) · Bipolar Disorders · doi:10.1111/bdi.12227 · Cited by 47 · see citing works

Reduced Brain-Derived Neurotrophic Factor Serum Concentrations in Acute Schizophrenic Patients Increase During Antipsychotic Treatment

Lee, A. H., Lange, C., Ricken, R., Hellweg, R., & Lang, U. E. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31821895c1 · Cited by 47 · see citing works

Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death

Kim, Y. J., Ko, H. H., Han, E. S., & Lee, C. S. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.12.006 · Cited by 46 · see citing works

Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) Gene Associated with Treatment Response to Mood Stabilizers in Patients with Bipolar I Disorder

Wang, Z., Fan, J., Gao, K., Li, Z., Yi, Z., Wang, L., Huang, J., Yuan, C., Hong, W., Yu, S., et al. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9956-0 · Cited by 46 · see citing works

Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system

Gruber, O., Hasan, A., Scherk, H., Wobrock, T., Schneider-Axmann, T., Ekawardhani, S., Schmitt, A., Backens, M., Reith, W., Meyer, J., et al. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0214-6 · Cited by 45 · see citing works

Quetiapine for bipolar depression: a systematic review and meta-analysis

Chiesa, A., Chierzi, F., De Ronchi, D., & Serretti, A. (2012) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32834e4c56 · Cited by 45 · see citing works

Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes

Fernandes, B. S., Gama, C. S., Walz, J. C., Ceresér, K. M. M., Fries, G. R., Colpo, G. D., de Aguiar, B. W., Pfaffenseller, B., Kauer‐Sant’Anna, M., & Kapczinski, F. P. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.11.020 · Cited by 44 · see citing works

Glutamatergic Effects of Divalproex in Adolescents With Mania: A Proton Magnetic Resonance Spectroscopy Study

Strawn, J. R., Patel, N. C., Chu, W., Lee, J. H., Adler, C. M., Kim, M. J., Bryan, H., Alfieri, D. C., Welge, J. A., Blom, T. J., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.03.009 · Cited by 44 · see citing works

Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression

Dean, O. M., Turner, A., Malhi, G. S., Ng, C. H., Cotton, S., Dodd, S., Sarris, J. J., Samuni, Y., Tanious, M., Dowling, N. L., et al. (2014) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1341 · Cited by 43 · see citing works

Aripiprazole altered plasma levels of brain‐derived neurotrophic factor and catecholamine metabolites in first‐episode untreated Japanese schizophrenia patients

Yoshimura, R., Hori, H., Ikenouchi, A., Umene‐Nakano, W., Katsuki, A., Hayashi, K., Atake, K., Tomita, M., & Nakamura, J. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1257 · Cited by 43 · see citing works

The inflammatory cytokines: molecular biomarkers for major depressive disorder?

Martin, C., Tansey, K. E., Schalkwyk, L. C., & Powell, T. R. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.29 · Cited by 40 · see citing works

Single Ketamine Infusion and Neurocognitive Performance in Bipolar Depression

Permoda-Osip, A., Kisielewski, J., Bartkowska-Sniatkowska, A., & Rybakowski, J. (2014) · Pharmacopsychiatry · doi:10.1055/s-0034-1394399 · Cited by 40 · see citing works

Cardiovascular and psychiatric characteristics associated with oxidative stress markers among adolescents with bipolar disorder

Hatch, J., Andreazza, A., Olowoyeye, O., Rezin, G. T., Moody, A., & Goldstein, B. I. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.04.005 · Cited by 39 · see citing works

Vitamin B12 Level may be Related to the Efficacy of Single Ketamine Infusion in Bipolar Depression

Permoda‐Osip, A., Dorszewska, J., Bartkowska‐Śniatkowska, A., Chłopocka-Woźniak, M., & RYBAKOWSKI, J. K. (2013) · Pharmacopsychiatry · doi:10.1055/s-0033-1349861 · Cited by 37 · see citing works

Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness

Caballero, J. L., Pacchiarotti, I., Murru, A., Valentí, M., Colom, F., Benach, B., Pérez, V., Dalmau, J. O., & Vieta, E. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.012 · Cited by 36 · see citing works

Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder

Fries, G. R., Vasconcelos-Moreno, M. P., Gubert, C., Tietbohl-Santos, B., da Rosa, A. L. S. T., Eisele, B. S., Sartori, J., Pfaffenseller, B., Kapczinski, F. P., & Kauer‐Sant’Anna, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.027 · Cited by 34 · see citing works

Factors connected with efficacy of single ketamine infusion in bipolar depression

Permoda‐Osip, A., Skibińska, M., Bartkowska‐Śniatkowska, A., Kliwicki, S., Chłopocka-Woźniak, M., & RYBAKOWSKI, J. K. (2014) · Psychiatria Polska · doi:10.12740/pp/21175 · Cited by 34 · see citing works

Peripheral brain-derived neurotrophic factor changes along treatment with extended release quetiapine during acute mood episodes: An open-label trial in drug-free patients with bipolar disorder

Grande, I., Kapczinski, F. P., Stertz, L., Colpo, G. D., Kunz, M., Ceresér, K. M., Kauer‐Sant’Anna, M., Frey, B. N., Vieta, E., & Magalhães, P. V. D. S. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.08.017 · Cited by 33 · see citing works

Ketamine Anesthesia, Efficacy of Electroconvulsive Therapy, and Cognitive Functions in Treatment-Resistant Depression

Rybakowski, J., Bodnar, A., Krzywotulski, M., Chłopocka‐Woźniak, M., Michalak, M., Rosada-Kurasińska, J., & Bartkowska-Śniatkowska, A. (2016) · Journal of ECT · doi:10.1097/yct.0000000000000317 · Cited by 33 · see citing works

Positive association between the brain‐derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population

Xu, J., Liu, Y., Wang, P., Li, S., Wang, Y., Li, J., Zhou, D., Chen, Z., Zhao, T., Wang, T., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30953 · Cited by 31 · see citing works

Three-Year, Naturalistic, Mirror-Image Assessment of Adding Memantine to the Treatment of 30 Treatment-Resistant Patients With Bipolar Disorder

Serra, G., Koukopoulos, A., Chiara, L. D., Koukopoulos, A. E., Tondo, L., Girardi, P., Baldessarini, R. J., & Serra, G. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08956 · Cited by 30 · see citing works

Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls

Berk, M., Bodemer, W., Oudenhove, T. V., & Butkow, N. (1994) · International Clinical Psychopharmacology · doi:10.1097/00004850-199400940-00009 · Cited by 29 · see citing works

Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder

Soontornniyomkij, B., Everall, I., Chana, G., Tsuang, M. T., Achim, C. L., & Soontornniyomkij, V. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.044 · Cited by 28 · see citing works

Increased platelet intracellular calcium ion concentration is specific to bipolar disorder

Dubovsky, S. L., Daurignac, E. C., & Leonard, K. E. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.025 · Cited by 26 · see citing works

Preserved white matter in unmedicated pediatric bipolar disorder

Teixeira, A. M. A., Kleinman, A., Zanetti, M. V., Jackowski, M. P., Duran, F., Pereira, F., Lafer, B., Busatto, G. F., & Caetano, S. C. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.06.061 · Cited by 25 · see citing works

Plasma fibrinogen: now also an antidepressant response marker?

Martins‐de‐Souza, D., Maccarrone, G., Ising, M., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.129 · Cited by 25 · see citing works

Divergent effects of lithium and sodium valproate on brain-derived neurotrophic factor (BDNF) production in human astrocytoma cells at therapeutic concentrations

Nishino, S., Ohtomo, K., Numata, Y., Sato, T., Nakahata, N., & Kurita, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.07.008 · Cited by 25 · see citing works

Risky alcohol use in young persons with emerging bipolar disorder is associated with increased oxidative stress

Chitty, K. M., Lagopoulos, J., Hickie, I. B., & Hermens, D. F. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.003 · Cited by 25 · see citing works

The effect of infliximab on depressive symptoms in patients with ankylosing spondylitis.

Bozkırlı, E. D. E., Keşkek, Ş. Ö., Bozkırlı, E., & Yücel, E. (2015) · PubMed · Cited by 24 · see citing works

Effects of lithium and valproic acid on BDNF protein and gene expression in an in vitro human neuron-like model of degeneration

Croce, N., Mathé, A. A., Gelfo, F., Caltagirone, C., Bernardini, S., & Angelucci, F. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114529379 · Cited by 21 · see citing works

Platelet uptake of GABA and glutamate in patients with bipolar disorder

Daniele, S., Pozzo, E. D., Abelli, M., Panighini, A., Pini, S., Gesi, C., Lari, L., Cardini, A., Cassano, G. B., & Martini, C. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01005.x · Cited by 19 · see citing works

Neuropathology markers and pathways associated with molecular targets for antipsychotic drugs in postmortem brain tissues: Exploration of drug targets through the Stanley Neuropathology Integrative Database

Kim, S., Zavitsanou, K., Gurguis, G. N. M., & Webster, M. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.01.010 · Cited by 18 · see citing works

Lithium Blocks 45Ca2+ Uptake into Platelets in Bipolar Affective Disorder and Controls

Berk, M., Kirchmann, N. H., & Butkow, N. (1996) · Clinical Neuropharmacology · doi:10.1097/00002826-199619010-00002 · Cited by 17 · see citing works

The effect of long-term lithium treatment of bipolar disorder on stem cells circulating in peripheral blood

Ferensztajn‐Rochowiak, E., Kucharska–Mazur, J., Samochowiec, J., Ratajczak, M. Z., Michalak, M., & RYBAKOWSKI, J. K. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2016.1174301 · Cited by 16 · see citing works

Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: Relation to treatment response

Paraskevas, G. P., Triantafyllou, N. I., Kapaki, E. N., et al. (2006) · Epilepsy Research · doi:10.1016/j.eplepsyres.2006.05.004 · Cited by 12 · see citing works

Memantine in the management of affective recurrences of bipolar disorders after the discontinuation of long-term lithium treatment: three case histories

Serra, G., Chiara, L. D., Manfredi, G., Koukopoulos, A. E., Sani, G., Girardi, P., Koukopoulos, A., & Serra, G. (2013) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125313507737 · Cited by 12 · see citing works

Chronic lithium chloride administration to rats decreases brain protein level of epsilon (ϵ) subunit of eukaryotic initiation factor-2B

Bosetti, F., Seemann, R., & Rapoport, S. I. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00354-3 · Cited by 11 · see citing works

Single-cell transcriptomic evidence for dense intracortical neuropeptide networks

Smith, S. J., Sümbül, U., Graybuck, L. T., Collman, F., Seshamani, S., Gala, R., Gliko, O., Elabbady, L., Miller, J. A., Bakken, T. E., et al. (2019) · eLife · doi:10.7554/elife.47889 · Cited by 156 · see citing works

Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

Saxena, A., Scaini, G., Bavaresco, D. V., Leite, C., Valvassoria, S. S., Carvalho, A. F., & Quevedo, J. (2017) · Complex Psychiatry · doi:10.1159/000480349 · Cited by 85 · see citing works

Recurrence of Lamotrigine-Associated Rash With Rechallenge

Ramos, R. H., & Budman, C. L. (1998) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v59n0207h · Cited by 7 · see citing works

[The function of fatty acid signals in neurogenesis].

Sakayori, N., & Osumi, N. (2011) · PubMed

[Lamotrigine in the therapy of resistant epilepsy].

Romanis, F. D., & Sopranzi, N. (2000) · PubMed · Cited by 11 · see citing works

Combined Leucopenia and Thrombocytopenia Are Possibly Adverse Events of Lamotrigine

Ebrahimi, H. A., & Zahedi, M. J. (2010) · Iranian journal of pharmacology & therapeutics · Cited by 1 · see citing works

Lymphadenopathy secondary to lamotrigine (Lamictal).

Marraffa, J. M., & Guharoy, R. (2002) · PubMed · Cited by 3 · see citing works