Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental-physical multimorbidity: cluster-randomised trial
Open accessAbstract
Background: Collaborative care can support the treatment of depression in people with long-term conditions, but long-term benefits and costs are unknown. Aims: To explore the long-term (24-month) effectiveness and cost-effectiveness of collaborative care in people with mental-physical multimorbidity. Method: A cluster randomised trial compared collaborative care (integrated physical and mental healthcare) with usual care for depression alongside diabetes and/or coronary heart disease. Depression symptoms were measured by the symptom checklist-depression scale (SCL-D13). The economic evaluation was from the perspective of the English National Health Service. Results: 191 participants were allocated to collaborative care and 196 to usual care. At 24 months, the mean SCL-D13 score was 0.27 (95% CI, −0.48 to −0.06) lower in the collaborative care group alongside a gain of 0.14 (95% CI, 0.06-0.21) quality-adjusted life-years (QALYs). The cost per QALY gained was £13 069. Conclusions: In the long term, collaborative care reduces depression and is potentially cost-effective at internationally accepted willingness-to-pay thresholds. Declaration of interest: None.
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Belief in the superiority of an intervention, or researcher allegiance, has been associated with stronger observed effects of therapies, particularly in psychotherapy research.
“Belief in the superiority of an intervention, or researcher allegiance, 583 has been associated with stronger observed effects of therapies, particularly in psychotherapy research. 584”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [583]
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Phuc, H. T., Chi, N. P. Q., Giang, T. N. T., Thuy, N. T. T., & Nhi, V. N. Y. (2025) · TẠP CHÍ KHOA HỌC TRƯỜNG ĐẠI HỌC QUỐC TẾ HỒNG BÀNG · doi:10.59294/hiujs20250117
- Authors
- Camacho, E. M., Davies, L. M., Hann, M., Small, N., Bower, P., Chew-Graham, C., Baguely, C., Gask, L., Dickens, C. M., Lovell, K., Waheed, W., Gibbons, C. J., & Coventry, P.
- Affiliations
- University of Manchester (GB)
- Manchester Academic Health Science Centre (GB)
- Health Education North West (GB)
- University of Exeter (GB)
- University of York (GB)
- Corresponding author
- Camacho, Elizabeth M.
- ORCID
- Venue
- The British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2018-05-15
- Volume
- 213
- Issue
- 2
- Pages
- 456-463
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC6429252
- OpenAlex
- W2794766259
- Cited by
- 66
- References
- 27
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 8 · 2018: 3
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Keele Research Repository (Keele University) (submittedVersion, cc-by)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, cc-by)
- Funders
- National Institute for Health and Care Research
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- collaborative care, depression, diabetes mellitus, coronary artery disease, chronic disease, cost-effectiveness, quality-adjusted life years, usual care
- MeSH terms
- Multimorbidity, Aged, Coronary Disease, Cost-Benefit Analysis, Depression, Female, Humans, Male, Middle Aged, Patient Care Team, Primary Health Care, Quality of Life, Surveys and Questionnaires, Cluster Analysis, Linear Models, Delivery of Health Care, Integrated, Quality-Adjusted Life Years, Diabetes Complications
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