The role of relapse prevention for depression in collaborative care: a systematic review
Open accessAbstract
BACKGROUND Relapse (the re-emergence of depression symptoms before full recovery) is common in depression and relapse prevention strategies are not well researched in primary care settings. Collaborative care is effective for treating acute phase depression but little is known about the use of relapse prevention strategies in collaborative care. We undertook a systematic review to identify and characterise relapse prevention strategies in the context of collaborative care. METHODS We searched for Randomised Controlled Trials (RCTs) of collaborative care for depression. In addition to published material, we obtained provider and patient manuals from authors to provide more detail on intervention content. We reported the extent to which collaborative care interventions addressed four relapse prevention components. RESULTS 93 RCTs were identified. 31 included a formal relapse prevention plan; 42 had proactive monitoring and follow-up after the acute phase; 39 reported strategies for optimising sustained medication adherence; and 20 of the trials reported psychological or psycho-educational treatments persisting beyond the acute phase or focussing on long-term health/relapse prevention. 30 (32.3%) did not report relapse prevention approaches. LIMITATIONS We did not receive trial materials for approximately half of the trials, which limited our ability to identify relevant features of intervention content. CONCLUSION Relapse is a significant risk amongst people treated for depression and interventions are needed that specifically address and minimise this risk. Given the advantages of collaborative care as a delivery system for depression care, there is scope for more consistency and increased effort to implement and evaluate relapse prevention strategies.
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Hospitalization is the administrative criterion mentioned in the largest number of articles, being mentioned in 42 of the 51 (82.3%) articles included in the review.
“Regarding the administrative criteria that have been established, the one mentioned in the largest number of articles is hospitalization, being mentioned in 42 of the 51 (82,3%) articles included in the review (1, 2, 4–7, 9–17, 19–21, 23–31, 34, 35, 41–45, 47–52, 54, 55).”
From Administrative criteria in the relapse of depressive disorder: a critical appraisal (2026) · cites this paper as [6]
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We need a chronic disease management model for depression in primary care.
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Telephone Depression Care Management for Latino Medicaid Health Plan Members
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A Randomized Trial of Collaborative Care in Patients With Diabetes and Depression
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Project Direct: Pilot Study of A Collaborative Intervention for Depressed Seniors
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3 of the 128 references couldn’t be matched to a known paper.
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Primary Care and Mental Health: Overview of Integrated Care Models
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Moriarty, A. S., Castleton, J., McMillan, D., Riley, R. D., Snell, K. I. E., Archer, L., Paton, L. W., Gilbody, S. M., & Chew-Graham, C. A. (2024) · Health Expectations · doi:10.1111/hex.70059 · Cited by 6 · see citing works
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Nawaz, S., Bee, P., & Faija, C. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.12.054 · Cited by 4 · see citing works
Bliddal, M., Wesselhoeft, R. T., Rasmussen, L., Janecka, M., Zaks, N., Petersen, L. K., Egsgaard, S., Jensen, P. B., & Munk‐Olsen, T. (2025) · Psychological Medicine · doi:10.1017/s0033291725102602 · Cited by 4 · see citing works
Christensen, J., Hindmarch, G., Cueto, L., Rabinowitz, M., Carrejo, V., Jeansonne, S., Bettler, J., Williams, S., Komaromy, M. S., Watkins, K. E., et al. (2025) · Family Practice · doi:10.1093/fampra/cmaf007 · Cited by 3 · see citing works
Relapse prevention following guided self-help for common health problems: A Scoping Review
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Moving beyond accuracy to overcome translational barriers in depression relapse prediction
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C-L Case Conference: Chronic Psychosis Managed in Collaborative Care
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Bernal-Cueto, S., Cegla-Schvartzman, F., & Baca-García, E. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1796386
“In the clinical setting, relapse of MDD is traditionally de fi ned as the reappearance of depressive symptoms within a period of remission, but without reaching a complete recovery, as distinguished from recurrence, which implies a new episode after full recovery (6).”
Depressive Erkrankungen in der Hausarztpraxis
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DISCHARGE PLANNING PATIENT STROKE A NURSING SCIENCE PHILOSOPHY: SYSTEMATIC REVIEWPreprint
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- Authors
- Moriarty, A. S., Coventry, P. A., Hudson, J. L., Cook, N., Fenton, O. J., Bower, P., Lovell, K., Archer, J., Clarke, R., Richards, D. A., Dickens, C., Gask, L., Waheed, W., Huijbregts, K. M., van der Feltz–Cornelis, C., Ali, S., Gilbody, S., & McMillan, D.
- Affiliations
- University of York (GB)
- King's College London (GB)
- Tees, Esk and Wear Valleys NHS Foundation Trust (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- University of Salford (GB)
- University of Exeter (GB)
- Streekziekenhuis Koningin Beatrix (NL)
- Western University (CA)
- Corresponding author
- Moriarty, Andrew S
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 265
- Pages
- 618-644
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2991561062
- Semantic Scholar
- e5606ea70be1937df57ec645f5a6078fe6fa8921
- Cited by
- 35
- References
- 128
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- usir.salford.ac.uk
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion)
- Figshare (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- University of Salford Institutional Repository (University of Salford) (submittedVersion, cc-by)
- Funders
- ASM
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- relapse prevention, depression, collaborative care, primary care, medication adherence, psychoeducational intervention, intervention content
- MeSH terms
- Chronic Disease, Depression, Humans, Primary Health Care, Recurrence, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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