Cited by 111Face Recognition and PerceptionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

Short-term antidepressant treatment and facial processing: Functional magnetic resonance imaging study

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Norbury, Ray, Mackay, Clare E., Cowen, Philip J., Goodwin, Guy M., Harmer, Catherine J.·2007·British Journal of Psychiatry

Abstract

Summary: We used functional magnetic resonance imaging to investigate the effects of short-term treatment with reboxetine, a selective noradrenaline reuptake inhibitor, on emotional facial processing in healthy volunteers. Reboxetine was associated with a reduced amygdala response to fearful faces and increased activation to happy v. neutral facial expressions in the right fusiform gyrus, relative to placebo treatment and in the absence of changes in mood. Our results show that reboxetine modulates the neural substrates of emotional processing, highlighting a mechanism by which drug treatment could normalise negative bias in depression and anxiety.

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Crossref · 10.1192/bjp.bp.106.031393

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  • In healthy volunteers, SSRIs and SNRIs at dosing regimens of between 7 and 21 days reduce amygdala activity to threatening facial expressions or increase amygdala responses to positive facial expressions.

    “In healthy volunteers, SSRIs and SNRIs at dosing regimens of between 7 and 21 days show similar effects of reducing amygdala activity to threatening facial expressions47-50 or increasing amygdala responses to positive facial expressions.51”
  • Antidepressant medications reduce amygdala activation to threatening stimuli and increase visual association cortex response to positive stimuli.

    “Direct experimental evidence indicates that antidepressant medications reduce amygdala activation to threatening stimuli and increase visual association cortex response to positive stimuli (16–21)”
  • Antidepressant drugs may alter attentional habit via an effect on early stimulus appraisal rather than on higher order control processes.

    “suggesting that these drugs may alter attentional habit via an effect on early stimulus appraisal rather than on higher order control processes.”

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Authors
Norbury, R., Mackay, C. E., Cowen, P. J., Goodwin, G. M., & Harmer, C. J.
Affiliations
  • John Radcliffe Hospital (GB)
  • Warneford Hospital (GB)
Corresponding author
Norbury, Ray
Venue
British Journal of Psychiatry
Published
2007-06
Volume
190
Issue
6
Pages
531-532
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2011082377
Cited by
111
References
12
Citations by year
2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 11 · 2014: 3 · 2013: 9 · 2012: 6
FWCI
6.82
Type
journal article
Language
en
Open access
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
reboxetine, antidepressant treatment, amygdala, fearful faces, fusiform gyrus, facial expression recognition, norepinephrine reuptake inhibition, depression, anxiety, negative bias, placebo
MeSH terms
Reboxetine, Antidepressive Agents, Facial Expression, Female, Humans, Magnetic Resonance Imaging, Male, Morpholines, Pattern Recognition, Visual, Treatment Outcome

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