Short-term antidepressant treatment and facial processing: Functional magnetic resonance imaging study
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Summary: We used functional magnetic resonance imaging to investigate the effects of short-term treatment with reboxetine, a selective noradrenaline reuptake inhibitor, on emotional facial processing in healthy volunteers. Reboxetine was associated with a reduced amygdala response to fearful faces and increased activation to happy v. neutral facial expressions in the right fusiform gyrus, relative to placebo treatment and in the absence of changes in mood. Our results show that reboxetine modulates the neural substrates of emotional processing, highlighting a mechanism by which drug treatment could normalise negative bias in depression and anxiety.
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In healthy volunteers, SSRIs and SNRIs at dosing regimens of between 7 and 21 days reduce amygdala activity to threatening facial expressions or increase amygdala responses to positive facial expressions.
“In healthy volunteers, SSRIs and SNRIs at dosing regimens of between 7 and 21 days show similar effects of reducing amygdala activity to threatening facial expressions47-50 or increasing amygdala responses to positive facial expressions.51”
From The effects of drugs on human models of emotional processing: an account of antidepressant drug treatment (2015) · cites this paper as [48]
Antidepressant medications reduce amygdala activation to threatening stimuli and increase visual association cortex response to positive stimuli.
“Direct experimental evidence indicates that antidepressant medications reduce amygdala activation to threatening stimuli and increase visual association cortex response to positive stimuli (16–21)”
From Lateral prefrontal cortex mediates the cognitive modification of attentional bias (2010) · cites this paper as [19]
Antidepressant drugs may alter attentional habit via an effect on early stimulus appraisal rather than on higher order control processes.
“suggesting that these drugs may alter attentional habit via an effect on early stimulus appraisal rather than on higher order control processes.”
From Lateral prefrontal cortex mediates the cognitive modification of attentional bias (2010) · cites this paper as [19]
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Ironside, M., Browning, M. D., Ansari, T. L., Harvey, C., Sekyi-Djan, M. N., Bishop, S. J., Harmer, C. J., & O’Shea, J. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/215699 · Cited by 8 · see citing works
Self-citationPineau, G., Jean, E., Romo, L., Villemain, F., Poupon, D., & Gorwood, P. A. P. M. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114401 · Cited by 6 · see citing works
The Role of Serotonin in Aversive Inhibition: Behavioural, Cognitive and Neural Perspectives
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Treatment-Induced Brain Plasticity in Psychiatric Disorders
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Effects of repeated intravenous esketamine administration on affective biases
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The cognitive neuropsychological model of antidepressant response
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Self-citationNeurotransmitter modulation of human facial emotion recognition
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Self-citationBiomarkers for the Development of Antidepressant and Anxiolytic Drugs
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Self-citationMISATTRIBUTION OF EMOTIONAL OVER-AROUSAL TO NEUTRAL FACES IN ACUTE PARANOID SCHIZOPHRENIA PSYCHOSIS
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Applications of MRI to Psychopharmacology
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- Authors
- Norbury, R., Mackay, C. E., Cowen, P. J., Goodwin, G. M., & Harmer, C. J.
- Affiliations
- John Radcliffe Hospital (GB)
- Warneford Hospital (GB)
- Corresponding author
- Norbury, Ray
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2007-06
- Volume
- 190
- Issue
- 6
- Pages
- 531-532
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2011082377
- Cited by
- 111
- References
- 12
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 11 · 2014: 3 · 2013: 9 · 2012: 6
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- reboxetine, antidepressant treatment, amygdala, fearful faces, fusiform gyrus, facial expression recognition, norepinephrine reuptake inhibition, depression, anxiety, negative bias, placebo
- MeSH terms
- Reboxetine, Antidepressive Agents, Facial Expression, Female, Humans, Magnetic Resonance Imaging, Male, Morpholines, Pattern Recognition, Visual, Treatment Outcome
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