The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Effect of a single dose of citalopram on amygdala response to emotional faces
Open accessAbstract
Background: Selective serotonin reuptake inhibitors (SSRIs) are typically thought to have a delay of several weeks in the onset of their clinical effects. However, recent reports suggest they may have a much earlier therapeutic onset. A reduction in amygdala responsivity has been implicated in the therapeutic action of SSRIs. Aims: To investigate the effect of a single dose of an SSRI on the amygdala response to emotional faces. Method: Twenty-six healthy volunteers were randomised to receive a single oral dose of citalopram (20 mg) or placebo. Effects on the processing of facial expressions were assessed 3 h later using functional magnetic resonance imaging. Results: Volunteers treated with citalopram displayed a significantly reduced amygdala response to fearful facial expressions compared with placebo. Conclusions: Such an immediate effect of an SSRI on amygdala responses to threat supports the idea that antidepressants have an earlier onset of therapeutically relevant effects than conventionally thought.
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“In reality, however, the evidence following single-dose treatment is rather mixed, and both increases in amygdala reactivity52 and decreases53 have been reported; see for example the recent review in ref 54 and metaanalysis in ref 55.”
From The effects of drugs on human models of emotional processing: an account of antidepressant drug treatment (2015) · cites this paper as [53]
In the citing paper
“Direct experimental evidence indicates that antidepressant medications reduce amygdala activation to threatening stimuli and increase visual association cortex response to positive stimuli (16–21)”
From Lateral prefrontal cortex mediates the cognitive modification of attentional bias (2010) · cites this paper as [20]
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“suggesting that these drugs may alter attentional habit via an effect on early stimulus appraisal rather than on higher order control processes.”
From Lateral prefrontal cortex mediates the cognitive modification of attentional bias (2010) · cites this paper as [20]
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An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
(1970) · Cited by 24,983
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036
Research works printed but not linked: 2
- Nelson, 1991, National Adult Reading Test (NART)
- First, 1997, Structured Clinical Interview for DSM–IV Axis I Disorders (SCID–I)
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Dannlowski, U., Stuhrmann, A., Beutelmann, V., Zwanzger, P., Lenzen, T., Grotegerd, D., Domschke, K., Hohoff, C., Ohrmann, P., Bauer, J., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.021 · Cited by 954
How do antidepressants work? New perspectives for refining future treatment approaches
Harmer, C. J., Duman, R. S., & Cowen, P. J. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30015-9 · Cited by 616
Self-citationCognitive Mechanisms of Treatment in Depression
Roiser, J. P., Elliott, R., & Sahakian, B. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.183 · Cited by 535
Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3810-0 · Cited by 522
Self-citationEffect of Acute Antidepressant Administration on Negative Affective Bias in Depressed Patients
Harmer, C. J., O’Sullivan, U., Favaron, E., Massey-Chase, R., Ayres, R., Reinecke, A., Goodwin, G. M., & Cowen, P. J. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09020149 · Cited by 485
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Metadata
- Authors
- Murphy, S. E., Norbury, R., O'Sullivan, U., Cowen, P. J., & Harmer, C. J.
- Affiliations
- Warneford Hospital (GB)
- Corresponding author
- Murphy, Susannah E.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2009-06
- Volume
- 194
- Issue
- 6
- Pages
- 535-540
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC2802527
- OpenAlex
- W2135286048
- Cited by
- 255
- References
- 42
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 12 · 2023: 6 · 2022: 15 · 2021: 17 · 2020: 14 · 2019: 12 · 2018: 12 · 2017: 13 · 2016: 10 · 2015: 19 · 2014: 15 · 2013: 28 · 2012: 15
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- citalopram, selective serotonin reuptake inhibitors, amygdala, emotional facial expressions, facial expression processing, fear, antidepressant onset of action, threat processing
- MeSH terms
- Adult, Amygdala, Emotions, Facial Expression, Female, Humans, Magnetic Resonance Imaging, Male, Citalopram, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation, Young Adult
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