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Preventing progression to first-episode psychosis in early initial prodromal states

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Bechdolf, A., Wagner, M., Ruhrmann, S., Harrigan, S., Putzfeld, V., Pukrop, R., Brockhaus-Dumke, A., Berning, J., Janssen, B., Decker, P., Bottlender, R., Maurer, K., Möller, H.-J., Gaebel, W., Häfner, H., Maier, W., Klosterkötter, J.·2012·British Journal of Psychiatry

DOI 10.1192/bjp.bp.109.066357

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Abstract

Background: Young people with self-experienced cognitive thought and perception deficits (basic symptoms) may present with an early initial prodromal state (EIPS) of psychosis in which most of the disability and neurobiological deficits of schizophrenia have not yet occurred. Aims: To investigate the effects of an integrated psychological intervention (IPI), combining individual cognitive–behavioural therapy, group skills training, cognitive remediation and multifamily psychoeducation, on the prevention of psychosis in the EIPS. Method: A randomised controlled, multicentre, parallel group trial of 12 months of IPI v. supportive counselling (trial registration number: NCT00204087). Primary outcome was progression to psychosis at 12- and 24-month follow-up. Results: A total of 128 help-seeking out-patients in an EIPS were randomised. Integrated psychological intervention was superior to supportive counselling in preventing progression to psychosis at 12-month follow-up (3.2% v. 16.9%; P = 0.008) and at 24-month follow-up (6.3% v. 20.0%; P = 0.019). Conclusions: Integrated psychological intervention appears effective in delaying the onset of psychosis over a 24-month time period in people in an EIPS.

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Ключевые слова: острые преходящие психотические расстройства; шизофрения; первый психотический эпизод; расстройства шизофренического спектра
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Authors: Bechdolf, A., Wagner, M., Ruhrmann, S., Harrigan, S., Putzfeld, V., Pukrop, R., Brockhaus-Dumke, A., Berning, J., Janssen, B., Decker, P., Bottlender, R., Maurer, K., Möller, H.-J., Gaebel, W., Häfner, H., Maier, W., & Klosterkötter, J.
Affiliations: The University of Melbourne (AU)
University of Bonn (DE)
University of Cologne (DE)
Heinrich Heine University Düsseldorf (DE)
Ludwig-Maximilians-Universität München (DE)
Central Institute of Mental Health (DE)
Corresponding author: Bechdolf, A.
ORCID: Bechdolf, A.
Wagner, M.
Ruhrmann, S.
Harrigan, S.
Berning, J.
Häfner, H.
Maier, W.
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2012-01
Volume: 200
Issue: 1
Pages: 22-29
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.109.066357
OpenAlex: W2153557212
Cited by: 224
References: 49
Citations by year: 2026: 5 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 17 · 2019: 20 · 2018: 13 · 2017: 11 · 2016: 21 · 2015: 22 · 2014: 24 · 2013: 34 · 2012: 15
FWCI: 16.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 2193 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung (01GI9935)
Universität zu Köln
Rheinische Friedrich-Wilhelms-Universität Bonn
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: psychosis prevention, first-episode psychosis, cognitive behavioral therapy, cognitive remediation, group skills training, supportive counseling, basic symptoms, schizophrenia
MeSH terms: Adolescent, Adult, Ambulatory Care, Counseling, Disease Susceptibility, Family Health, Female, Humans, Male, Patient Education as Topic, Prospective Studies, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Time Factors, Cognitive Behavioral Therapy, Treatment Outcome, Disease Progression, Kaplan-Meier Estimate, Young Adult

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Preventing progression to first-episode psychosis in early initial prodromal states

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