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Cited by 224Schizophrenia research and treatmentMaternal Mental Health During Pregnancy and PostpartumPsychoanalysis and Psychopathology Research

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Preventing progression to first-episode psychosis in early initial prodromal states

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Bechdolf, A., Wagner, M., Ruhrmann, S., Harrigan, S., Putzfeld, V., Pukrop, R., Brockhaus-Dumke, A., Berning, J., Janssen, B., Decker, P., Bottlender, R., Maurer, K., Möller, H.-J., Gaebel, W., Häfner, H., Maier, W., Klosterkötter, J.·2012·British Journal of Psychiatry
DOI 10.1192/bjp.bp.109.066357
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Abstract

Background: Young people with self-experienced cognitive thought and perception deficits (basic symptoms) may present with an early initial prodromal state (EIPS) of psychosis in which most of the disability and neurobiological deficits of schizophrenia have not yet occurred. Aims: To investigate the effects of an integrated psychological intervention (IPI), combining individual cognitive–behavioural therapy, group skills training, cognitive remediation and multifamily psychoeducation, on the prevention of psychosis in the EIPS. Method: A randomised controlled, multicentre, parallel group trial of 12 months of IPI v. supportive counselling (trial registration number: NCT00204087). Primary outcome was progression to psychosis at 12- and 24-month follow-up. Results: A total of 128 help-seeking out-patients in an EIPS were randomised. Integrated psychological intervention was superior to supportive counselling in preventing progression to psychosis at 12-month follow-up (3.2% v. 16.9%; P = 0.008) and at 24-month follow-up (6.3% v. 20.0%; P = 0.019). Conclusions: Integrated psychological intervention appears effective in delaying the onset of psychosis over a 24-month time period in people in an EIPS.

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Research works printed but not linked: 6

  1. Bechdolf, 2006, Working with People at Ultra-high Risk of Developing Psychosis
  2. Haefner, 2011, Early Detection and Intervention in Psychosis. A Practise Handbook
  3. 2000, Practice guideline for the treatment of patients with major depressive disorder (revision), Am J Psychiatry, 157, 1
  4. McGorry, 2002, Can first episode psychosis be delayed or prevented? A randomized controlled trial of interventions during the prepsychotic phase of schizophrenia and related psychosis, Arch Gen Psychiatry, 59
  5. Bechdolf, 2010, Cognitive Behavioural Therapy in People at Risk of Psychosis
  6. 1994, Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition)

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Metadata

Authors
Bechdolf, A., Wagner, M., Ruhrmann, S., Harrigan, S., Putzfeld, V., Pukrop, R., Brockhaus-Dumke, A., Berning, J., Janssen, B., Decker, P., Bottlender, R., Maurer, K., Möller, H.-J., Gaebel, W., Häfner, H., Maier, W., & Klosterkötter, J.
Affiliations
  • The University of Melbourne (AU)
  • University of Bonn (DE)
  • University of Cologne (DE)
  • Heinrich Heine University Düsseldorf (DE)
  • Ludwig-Maximilians-Universität München (DE)
  • Central Institute of Mental Health (DE)
Corresponding author
Bechdolf, A.
ORCID
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
2012-01
Volume
200
Issue
1
Pages
22-29
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.bp.109.066357
OpenAlex
W2153557212
Cited by
224
References
49
Citations by year
2026: 5 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 17 · 2019: 20 · 2018: 13 · 2017: 11 · 2016: 21 · 2015: 22 · 2014: 24 · 2013: 34 · 2012: 15
FWCI
16.63
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 2193 d)
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bundesministerium für Bildung und Forschung (01GI9935)
  • Universität zu Köln
  • Rheinische Friedrich-Wilhelms-Universität Bonn
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
psychosis prevention, first-episode psychosis, cognitive behavioral therapy, cognitive remediation, group skills training, supportive counseling, basic symptoms, schizophrenia
MeSH terms
Adolescent, Adult, Ambulatory Care, Counseling, Disease Susceptibility, Family Health, Female, Humans, Male, Patient Education as Topic, Prospective Studies, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Time Factors, Cognitive Behavioral Therapy, Treatment Outcome, Disease Progression, Kaplan-Meier Estimate, Young Adult

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