Rapid-cycling bipolar disorder: cross-national community study
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Background: The epidemiology of rapid-cycling bipolar disorder in the community is largely unknown. Aims: To investigate the epidemiological characteristics of rapid-cycling and non-rapid-cycling bipolar disorder in a large cross-national community sample. Method: The Composite International Diagnostic Interview (CIDI version 3.0) was used to examine the prevalence, severity, comorbidity, impairment, suicidality, sociodemographics, childhood adversity and treatment of rapid-cycling and non-rapid-cycling bipolar disorder in ten countries (n = 54 257). Results: The 12-month prevalence of rapid-cycling bipolar disorder was 0.3%. Roughly a third and two-fifths of participants with lifetime and 12-month bipolar disorder respectively met criteria for rapid cycling. Compared with the non-rapid-cycling, rapid-cycling bipolar disorder was associated with younger age at onset, higher persistence, more severe depressive symptoms, greater impairment from depressive symptoms, more out-of-role days from mania/hypomania, more anxiety disorders and an increased likelihood of using health services. Associations regarding childhood, family and other sociodemographic correlates were less clear cut. Conclusions: The community epidemiological profile of rapid-cycling bipolar disorder confirms most but not all current clinically based knowledge about the illness.
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Rapid cycling, or a course of illness that includes four or more mood episodes a year, affects up to one-third of patients with BDI.
“Rapid cycling, or a course of illness that includes four or more mood episodes a year, affects up to one‐third of patients with BDI.215, 216, 217, 218”
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Munkholm, K. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13495 · Cited by 2 · see citing works
Grover, S., Avasthi, A., Chakravarty, R. K., Dan, A., Chakraborty, K., Neogi, R., Desouza, A., Nayak, O., Praharaj, S. K., Menon, V., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.025 · Cited by 1 · see citing works
Epidemiologie und klinische Diagnostik bipolarer Erkrankungen
Krüger, S., & Bräunig, P. (2011) · Nervenheilkunde · doi:10.1055/s-0038-1627811 · Cited by 1 · see citing works
Bipolar disorder: A brief examination of lithium therapy
Farinde, A. (2013) · Journal of Basic and Clinical Pharmacy · doi:10.4103/0976-0105.121656 · Cited by 1 · see citing works
Mitochondria, Mood Lability, And Bone: MtSNPs’ Surprising Relationship To Mental Homeostasis
Mingo, E., & Stephens, C. E. (2024) · Advances In Clinical And Medical Research · doi:10.52793/acmr.2024.5(2)-s1 · Cited by 1 · see citing works
Keßler, U. (2014) · NORA - Norwegian Open Research Archives · Cited by 1 · see citing works
Hammen, C. L., & Keenan‐Miller, D. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop208005 · Cited by 1 · see citing works
Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamicsPreprint
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A REVIEW REGARDING THE EVOLUTION OF BIPOLAR DISORDER
Ienciu, M., Dehelean, L., Papava, S., & Giurgi-Oncu, C. (2011)
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Transtorno afetivo bipolar com ciclagem rápida: relato de caso
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Adverse Psychosocial Trajectory in Bipolar Disorder: Novel Genetic Links to ADHD and AnxietyPreprint
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Mixed Features and Rapid Cycling
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- Authors
- Lee, S., Tsang, A., Kessler, R. C., Jin, R., Sampson, N., Andrade, L., Karam, E. G., Mora, M. E. M., Merikangas, K., Nakane, Y., Popovici, D. G., Posada-Villa, J., Sagar, R., Wells, J. E., Zarkov, Z., & Petukhova, M.
- Affiliations
- Prince of Wales Hospital (CN)
- Chinese University of Hong Kong (HK)
- Harvard University (US)
- Universidade de São Paulo (BR)
- University of Balamand (LB)
- National Institutes of Health (US)
- Nagasaki International University (JP)
- National School of Public Health, Management and Professional Development (RO)
- All India Institute of Medical Sciences (IN)
- National Center of Public Health and Analyses (BG)
- Corresponding author
- Lee, Sing
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2010-03
- Volume
- 196
- Issue
- 3
- Pages
- 217-225
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC2830056
- OpenAlex
- W2097924822
- Cited by
- 57
- References
- 45
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2014: 6 · 2013: 5 · 2012: 2
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- John D. and Catherine T. MacArthur Foundation (R01 DA016558, R13-MH066849)
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Sanofi
- World Health Organization
- Janssen Scientific Affairs
- Fundação de Amparo à Pesquisa do Estado de São Paulo (03/00204-3, 03/00204?)
- Ministry of Health, Labour and Welfare (H14-TOKUBETSU-026, H13-SHOGAI-023)
- Shire
- Jawaharlal Institute Of Postgraduate Medical Education and Research
- National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
- Pfizer Foundation (R01‐MH069864, R01-DA016558, R13-MH066849, R03-TW006481)
- Pan American Health Organization (FIRCA R03-TW006481)
- National Institute of Mental Health (R13-MH-066849, R01‐MH070884, U01-MH-60220, MH069864, MH066849, U01MH060220, R01‐MH069864)
- National Institute on Drug Abuse (R01DA016558)
- Fogarty International Center (FIRCA R03TW006481, R03TW006481)
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- rapid cycling bipolar disorder, prevalence, depressive symptoms, manic symptoms, anxiety comorbidity, functional disability, suicidality, childhood adversity, age of onset, treatment utilization, cross-national comparison
- MeSH terms
- Adolescent, Adult, Aged, Anxiety Disorders, Bipolar Disorder, Cyclothymic Disorder, Epidemiologic Methods, Female, Humans, Life Change Events, Male, Maternal Deprivation, Middle Aged, Paternal Deprivation, Patient Acceptance of Health Care, Periodicity, Prevalence, Child of Impaired Parents, Domestic Violence, Age of Onset, Substance-Related Disorders, Young Adult
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