Cited by 184Mental Health Treatment and AccessSchizophrenia research and treatmentSuicide and Self-Harm Studies

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Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia

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Fekadu, Abebaw, Medhin, Girmay, Kebede, Derege, Alem, Atalay, Cleare, Anthony J., Prince, Martin, Hanlon, Charlotte, Shibre, Teshome·2015·British Journal of Psychiatry

DOI 10.1192/bjp.bp.114.149112

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Abstract

Background: Evidence on mortality in severe mental illness (SMI) comes primarily from clinical samples in high-income countries. Aims: To describe mortality in people with SMI among a population cohort from a low-income country. Method: We followed-up 919 adults (from 68 378 screened) with SMI over 10 years. Standardised mortality ratios (SMR) and years of life lost (YLL) as a result of premature mortality were calculated. Results: In total 121 patients (13.2%) died. The overall SMR was twice that of the general population; higher for men and people with schizophrenia. Patients died about three decades prematurely, mainly from infectious causes (49.6%). Suicide, accidents and homicide were also common causes of death. Conclusions: Mortality is an important adverse outcome of SMI irrespective of setting. Addressing common natural and unnatural causes of mortality are urgent priorities. Premature death and mortality related to self-harm should be considered in the estimation of the global burden of disease for SMI.

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Authors: Fekadu, A., Medhin, G., Kebede, D., Alem, A., Cleare, A. J., Prince, M., Hanlon, C., & Shibre, T.
Affiliations: King's College London (GB)
Corresponding author: Fekadu, Abebaw
ORCID: Fekadu, Abebaw
Medhin, Girmay
Alem, Atalay
Cleare, Anthony J.
Prince, Martin
Hanlon, Charlotte
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2015-04
Volume: 206
Issue: 4
Pages: 289-296
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.114.149112
OpenAlex: W2091355806
Cited by: 184
References: 49
Citations by year: 2026: 7 · 2025: 18 · 2024: 14 · 2023: 23 · 2022: 14 · 2021: 27 · 2020: 19 · 2019: 12 · 2018: 15 · 2017: 14 · 2016: 15 · 2015: 5
FWCI: 26.73
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 1007 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: World Health Organization
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Keywords: severe mental illness, mortality, premature mortality, schizophrenia, suicide, infectious disease mortality, years of life lost, global burden of disease, rural Ethiopia, low-income countries
MeSH terms: Accidents, Adolescent, Adult, Bipolar Disorder, Cause of Death, Depression, Ethiopia, Female, Homicide, Humans, Male, Middle Aged, Poverty, Rural Population, Schizophrenia, Suicide, Cohort Studies, Sex Distribution, Young Adult

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Excess mortality in severe mental illness: 10-year population-based cohort study in rural Ethiopia

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