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Psychological interventions for adults with bipolar disorder: systematic review and meta-analysis
Open accessAbstract
Background: Psychological interventions may be beneficial in bipolar disorder. Aims: To evaluate the efficacy of psychological interventions for adults with bipolar disorder. Method: A systematic review of randomised controlled trials was conducted. Outcomes were meta-analysed using RevMan and confidence assessed using the GRADE method. Results: We included 55 trials with 6010 participants. Moderate-quality evidence associated individual psychological interventions with reduced relapses at post-treatment (risk ratio (RR) = 0.66, 95% CI 0.48–0.92) and follow-up (RR = 0.74, 95% CI 0.63–0.87), and collaborative care with a reduction in hospital admissions (RR =0.68, 95% CI 0.49–0.94). Low-quality evidence associated group interventions with fewer depression relapses at post-treatment and follow-up, and family psychoeducation with reduced symptoms of depression and mania. Conclusions: There is evidence that psychological interventions are effective for people with bipolar disorder. Much of the evidence was of low or very low quality thereby limiting our conclusions. Further research should identify the most effective (and cost-effective) interventions for each phase of this disorder.
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“individual psychoeducation of at least five sessions would still be a first‐line intervention for relapse prevention, based on level 2 evidence.75, 79, 80”
From Canadian Network for Mood and Anxiety Treatments ( CANMAT ) and International Society for Bipolar Disorders ( ISBD ) 2018 guidelines for the management of patients with bipolar disorder (2018) · cites this paper as [79]
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“Psychological interventions for bipolar disorders typically produce mixed outcomes and modest effects.”
From What are People's Experiences of a Novel Cognitive Behavioural Therapy for Bipolar Disorders? A Qualitative Investigation with Participants on the TEAMS Trial. (2017) · cites this paper as Oud et al., 2016
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“3,4 This is a missed opportunity because manic episodes are the core syndrome of BD.”
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Brunner, J. (2016) · Psychotherapeut · doi:10.1007/s00278-016-0112-5
“Parallel ist Psychotherapie wirksam (insbesondere KVT; Oud et al. 2016).”
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Metadata
- Authors
- Oud, M., Mayo-Wilson, E., Braidwood, R., Schulte, P., Jones, S. H., Morriss, R., Kupka, R., Cuijpers, P., & Kendall, T.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Oud, Matthijs
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2016-03
- Volume
- 208
- Issue
- 3
- Pages
- 213-222
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2318692336
- Cited by
- 144
- References
- 92
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 11 · 2023: 14 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 4
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Lancaster EPrints (Lancaster University) (acceptedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Trimbos-instituut
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, psychological intervention, relapse prevention, collaborative care, group intervention, family psychoeducation, depression, mania, hospitalization, treatment efficacy
- MeSH terms
- Bipolar Disorder, Counseling, Depression, Family, Family Therapy, Humans, Mental Health, Recurrence, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Treatment Outcome
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