Cited by 144Bipolar Disorder and TreatmentPersonality Disorders and PsychopathologySchizophrenia research and treatment

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Psychological interventions for adults with bipolar disorder: systematic review and meta-analysis

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Oud, Matthijs, Mayo-Wilson, Evan, Braidwood, Ruth, Schulte, Peter, Jones, Steven H., Morriss, Richard, Kupka, Ralph, Cuijpers, Pim, Kendall, Tim·2016·British Journal of Psychiatry

DOI 10.1192/bjp.bp.114.157123

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Abstract

Background: Psychological interventions may be beneficial in bipolar disorder. Aims: To evaluate the efficacy of psychological interventions for adults with bipolar disorder. Method: A systematic review of randomised controlled trials was conducted. Outcomes were meta-analysed using RevMan and confidence assessed using the GRADE method. Results: We included 55 trials with 6010 participants. Moderate-quality evidence associated individual psychological interventions with reduced relapses at post-treatment (risk ratio (RR) = 0.66, 95% CI 0.48–0.92) and follow-up (RR = 0.74, 95% CI 0.63–0.87), and collaborative care with a reduction in hospital admissions (RR =0.68, 95% CI 0.49–0.94). Low-quality evidence associated group interventions with fewer depression relapses at post-treatment and follow-up, and family psychoeducation with reduced symptoms of depression and mania. Conclusions: There is evidence that psychological interventions are effective for people with bipolar disorder. Much of the evidence was of low or very low quality thereby limiting our conclusions. Further research should identify the most effective (and cost-effective) interventions for each phase of this disorder.

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Gomes, B. C., Abreu, L. N., Brietzke, E., Caetano, S. C., Kleinman, A., Nery, F. G., & Lafer, B. (2011) · Psychotherapy and Psychosomatics · doi:10.1159/000320738 · Cited by 52
A Comparison of the Life Goals Program and Treatment as Usual for Individuals With Bipolar Disorder
Sajatovic, M., Davies, M. A., Ganocy, S. J., Bauer, M. S., Cassidy, K. A., Hays, R. W., Safavi, R., Blow, F. C., & Calabrese, J. R. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.9.1182 · Cited by 51
Cognitive-Behavioural Therapy for Severe and Recurrent Bipolar Disorders: Randomised Controlled Trial
Scott, J. L., Paykel, E. S., Morriss, R. K., Bentall, R. P., Kinderman, P., Johnson, T. L., Abbott, R., & Hayhurst, H. (2007) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.5.1.64 · Cited by 48
Self-citation
A randomized comparison of online and paper mood charts for people with bipolar disorder
Lieberman, D. Z., Kelly, T. F., Douglas, L., & Goodwin, F. K. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.019 · Cited by 42
Clinical Significance of Inpatient Family Intervention: Conclusions From a Clinical Trial
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Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study
Fagiolini, A. M., Frank, E., Axelson, D., Birmaher, B. B., Cheng, Y., Curet, D. E., Friedman, E. S., Gildengers, A. G., Goldstein, T. R., Grochocinski, V. J., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00700.x · Cited by 37
Cognitive-Behavioral Therapy for Depression in Bipolar Disorder: A Meta-Analysis
Gregory, V. L. (2010) · Journal of Evidence-Based Social Work · doi:10.1080/15433710903176088 · Cited by 36
Group cognitive behavior therapy for bipolar disorder can improve the quality of life
da Costa, R. T., Cheniaux, E., Rangé, B., Versiani, M., & Nardi, A. E. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500109 · Cited by 30
Cognitive-Behavioral Therapy for Mania: A Meta-Analysis of Randomized Controlled Trials
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Short-Term Family-Focused Psycho- Educational Program for Bipolar Mood Disorder in Mashhad
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A Randomized Controlled Study of Cognitive Therapy for Relapse Prevention for Bipolar Affective Disorder: Outcome of the First Year
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Cognitive, interpersonal and psychsocial factors influencing vulnerability, treatment outcome and relapse in bipolar affective disorders : a clinical randomised controlled treatment trial
Schwannauer, M. (2007) · ERA · Cited by 3

Flagged first, then by citations

Research works printed but not linked: 5

2009, Depression in Adults; The Treatment and Management of Depression in Adults
2012, Review Manager (RevMan) Version 5.2
2014, Bipolar Disorder: The Management of Bipolar Disorder in Adults, Children and Adolescents, in Primary and Secondary Care
Kupka, 2015, Multidisciplinaire Richtlijn Bipolaire Stoornissen [Multidisciplinary Guidelines for Bipolar Disorders]
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Sorted by citations

Canadian Network for Mood and Anxiety Treatments ( CANMAT ) and International Society for Bipolar Disorders ( ISBD ) 2018 guidelines for the management of patients with bipolar disorder
Yatham, L. N., Kennedy, S. H., Parikh, S. V., Schaffer, A., Bond, D. J., Frey, B. N., Sharma, V., Goldstein, B. I., Rej, S., Beaulieu, S., et al. (2018) · Bipolar Disorders · doi:10.1111/bdi.12609 · Cited by 1,852
The Role of Common Factors in Psychotherapy Outcomes
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Self-citation
The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Malhi, G. S., Bell, E., Bassett, D., Boyce, P., Bryant, R., Hazell, P., Hopwood, M., Lyndon, B., Mulder, R., Porter, R., et al. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420979353 · Cited by 614
“Concerns still remain about the strength of the evidence base for psychological interventions (Goodwin et al., 2016; Murray, 2018; Oud et al., 2016), but best practice treatment of BD clearly involves the combination of medication and psychological treatment.”
Background
The efficacy of psychotherapies and pharmacotherapies for mental disorders in adults: an umbrella review and meta‐analytic evaluation of recent meta‐analyses
Leichsenring, F., Steinert, C., Rabung, S., & Ioannidis, J. P. A. (2022) · World Psychiatry · doi:10.1002/wps.20941 · Cited by 485
Efficacy of cognitive-behavioral therapy in patients with bipolar disorder: A meta-analysis of randomized controlled trials
Chiang, K., Tsai, J.-C., Liu, D., Lin, C., Chiu, H., & Chou, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176849 · Cited by 249

See all 144

Authors: Oud, M., Mayo-Wilson, E., Braidwood, R., Schulte, P., Jones, S. H., Morriss, R., Kupka, R., Cuijpers, P., & Kendall, T.
Affiliations: University of Nottingham (GB)
Corresponding author: Oud, Matthijs
ORCID: Oud, Matthijs
Schulte, Peter
Jones, Steven H.
Morriss, Richard
Kupka, Ralph
Cuijpers, Pim
Kendall, Tim
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2016-03
Volume: 208
Issue: 3
Pages: 213-222
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.114.157123
OpenAlex: W2318692336
Cited by: 144
References: 92
Citations by year: 2026: 7 · 2025: 13 · 2024: 11 · 2023: 14 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 4
FWCI: 2.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 672 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
VU Research Portal (publishedVersion, other-oa)
Lancaster EPrints (Lancaster University) (acceptedVersion)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Trimbos-instituut
National Institutes of Health
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: bipolar disorder, psychological intervention, relapse prevention, collaborative care, group intervention, family psychoeducation, depression, mania, hospitalization, treatment efficacy
MeSH terms: Bipolar Disorder, Counseling, Depression, Family, Family Therapy, Humans, Mental Health, Recurrence, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Treatment Outcome

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Psychological interventions for adults with bipolar disorder: systematic review and meta-analysis

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