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Cited by 386

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Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla

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Ren, Jimin, Dimitrov, Ivan, Sherry, A. Dean, Malloy, Craig R.·2008·Journal of Lipid Research

Abstract

Proton NMR spectroscopy at 7 Tesla (7T) was evaluated as a new method to quantify human fat composition noninvasively. In validation experiments, the composition of a known mixture of triolein, tristearin, and trilinolein agreed well with measurements by (1)H NMR spectroscopy. Triglycerides in calf subcutaneous tissue and tibial bone marrow were examined in 20 healthy subjects by (1)H spectroscopy. Ten well-resolved proton resonances from triglycerides were detected using stimulated echo acquisition mode sequence and small voxel ( approximately 0.1 ml), and T(1) and T(2) were measured. Triglyceride composition was not different between calf subcutaneous adipose tissue and tibial marrow for a given subject, and its variation among subjects, as a result of diet and genetic differences, fell in a narrow range. After correction for differential relaxation effects, the marrow fat composition was 29.1 +/- 3.5% saturated, 46.4 +/- 4.8% monounsaturated, and 24.5 +/- 3.1% diunsaturated, compared with adipose fat composition, 27.1 +/- 4.2% saturated, 49.6 +/- 5.7% monounsaturated, and 23.4 +/- 3.9% diunsaturated. Proton spectroscopy at 7T offers a simple, fast, noninvasive, and painless method for obtaining detailed information about lipid composition in humans, and the sensitivity and resolution of the method may facilitate longitudinal monitoring of changes in lipid composition in response to diet, exercise, and disease.

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Metadata

Authors
Ren, J., Dimitrov, I., Sherry, A. D., & Malloy, C. R.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2008-09
Volume
49
Issue
9
Pages
2055-2062
ISSN
0022-2275 (ISSN-L)
OpenAlex
W2164183759
Cited by
386
References
22
FWCI
10.04
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. https://app.cochat.ai/papers/10.1194/jlr.d800010-jlr200
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Ren, J., Dimitrov, I., Sherry, A. D., & Malloy, C. R. (2008). Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. Journal of Lipid Research. https://doi.org/10.1194/jlr.d800010-jlr200

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