Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat lipopolysaccharide model of neuroinflammation
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Neuroinflammation, caused by 6 days of intracerebroventricular infusion of a low dose of lipopolysaccharide (LPS; 0.5 ng/h), stimulates brain arachidonic acid (AA) metabolism in rats, but 6 weeks of lithium pretreatment reduces this effect. To further understand this action of lithium, we measured concentrations of eicosanoids and docosanoids generated from AA and docosahexaenoic acid (DHA), respectively, in high-energy microwaved rat brain using LC/MS/MS and two doses of LPS. In rats fed a lithium-free diet, low (0.5 ng/h)- or high (250 ng/h)-dose LPS compared with artificial cerebrospinal fluid increased brain unesterified AA and prostaglandin E(2) concentrations and activities of AA-selective Ca(2+)-dependent cytosolic phospholipase A(2) (cPLA(2))-IV and Ca(2+)-dependent secretory sPLA(2). LiCl feeding prevented these increments. Lithium had a significant main effect by increasing brain concentrations of lipoxygenase-derived AA metabolites, 5- hydroxyeicosatetraenoic acid (HETE), 5-oxo-eicosatetranoic acid, and 17-hydroxy-DHA by 1.8-, 4.3- and 1.9-fold compared with control diet. Lithium also increased 15-HETE in high-dose LPS-infused rats. Ca(2+)-independent iPLA(2)-VI activity and unesterified DHA and docosapentaenoic acid (22:5n-3) concentrations were unaffected by LPS or lithium. This study demonstrates, for the first time, that lithium can increase brain 17-hydroxy-DHA formation, indicating a new and potentially important therapeutic action of lithium.
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The most commonly used therapeutic drugs-lithium and valproate-were able to reverse the inflammatory state in mood disorders.
“Interestingly, the most commonly used therapeutic drugs—lithium and valproate—were able to reverse the inflammatory state in mood disorders [99–101].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [99]
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A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works
LITHIUM SALTS IN THE TREATMENT OF PSYCHOTIC EXCITEMENT
Cade, J. F. (1949) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1949.tb36912.x · Cited by 1,456 · see citing works
Meade, E. A., Smith, W. L., & DeWitt, D. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53294-4 · Cited by 1,262 · see citing works
Lithium salts in the treatment of psychotic excitement
Cade, J. F. (1999) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.1999.06241.x · Cited by 1,146 · see citing works
Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works
Serhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works
Phospholipase A2 structure/function, mechanism, and signaling
Burke, J. E., & Dennis, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800033-jlr200 · Cited by 933 · see citing works
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works
Lithium delays progression of amyotrophic lateral sclerosis
Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M. L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708022105 · Cited by 550 · see citing works
Belmaker, R. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra035354 · Cited by 473 · see citing works
Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 456 · see citing works
Rao, J. S., Harry, G. J., Rapoport, S. I., & Kim, H. W. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.47 · Cited by 432 · see citing works
Self-citationInflammation and immune regulation by 12/15-lipoxygenases
Kühn, H., & O’Donnell, V. B. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.02.003 · Cited by 399 · see citing works
Computer-Assisted Research Design and Analysis
Tabachnick, B. G., & Fidell, L. S. (2000) · Cited by 372 · see citing works
Role of inflammation in neurodegenerative diseases
Minghetti, L. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000169752.54191.97 · Cited by 335 · see citing works
Ziboh, V. A., Miller, C. C., & Cho, Y. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.361s · Cited by 310 · see citing works
Oka, S., & Arita, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92912-1 · Cited by 252 · see citing works
Robinson, P. J., Noronha, J. G. L., DeGeorge, J. J., Freed, L. M., Nariai, T., & Рапопорт, С. И. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90016-f · Cited by 250 · see citing works
Electrospray ionization and tandem mass spectrometry of eicosanoids
Murphy, R. C., Barkley, R. M., Berry, K. A. Z., Hankin, J. A., Harrison, K. A., Johnson, C. A., Krank, J., McAnoy, A. M., Uhlson, C. L., & Zarini, S. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.04.042 · Cited by 231 · see citing works
Self-citationStrokin, M., Sergeeva, M. G., & Reiser, G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705326 · Cited by 229 · see citing works
González‐Périz, A., Planagumà, A., Gronert, K., Miquel, R., López‐Parra, M., Titos, E., Horrillo, R., Ferré, N., Deulofeu, R., Arroyo, V., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6250fje · Cited by 226 · see citing works
A Paradigm for Gene Regulation: Inflammation, NF-κB and PPAR
Vanden Berghe, W., Vermeulen, L., Delerive, P., De Bosscher, K., Staels, B., & Haegeman, G. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9072-3_22 · Cited by 222 · see citing works
Lithium neuroprotection: molecular mechanisms and clinical implications
Rowe, M. K., & Chuang, D. (2004) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399404008385 · Cited by 194 · see citing works
Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET
Esposito, G., Giovacchini, G., Liow, J., Bhattacharjee, A. K., Greenstein, D. K., Schapiro, M. B., Hallett, M., Herscovitch, P., Eckelman, W. C., Carson, R. E., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.049619 · Cited by 182 · see citing works
Self-citationSmedt, V. D., Sargueil, F., Moranis, A., Harizi, H., Mongrand, S., & Layé, S. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05129.x · Cited by 174 · see citing works
Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease
Leyhe, T., Eschweiler, G. W., Stransky, E., Gasser, T., Annas, P., Basun, H., & Laske, C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1004 · Cited by 158 · see citing works
Bipolar disorder and mechanisms of action of mood stabilizers
Rapoport, S. I., Basselin, M., Kim, H., & Rao, J. S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.06.003 · Cited by 155 · see citing works
Self-citationLithium decreases turnover of arachidonate in several brain phospholipids
Chang, M., Grange, E., Rabin, O., Bell, J. M., Allen, D. D., & Rapoport, S. I. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13264-x · Cited by 150 · see citing works
Self-citationGroup-Specific Assays That Distinguish between the Four Major Types of Mammalian Phospholipase A2
Yang, H., Mosior, M. K., Johnson, C. A., Chen, Y., & Dennis, E. A. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4053 · Cited by 150 · see citing works
Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease
Moore, A. H., & O’Banion, M. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00162-x · Cited by 146 · see citing works
Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions
Geisbert, T. W., & Hensley, L. E. (2004) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399404008300 · Cited by 142 · see citing works
Bosetti, F., Rintala, J., Seemann, R., Rosenberger, T. A., Contreras, M. A., Рапопорт, С. И., & Chang, M. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001111 · Cited by 137 · see citing works
Search for a common mechanism of mood stabilizers
Harwood, A. J., & Agam, G. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00187-4 · Cited by 132 · see citing works
Rosenberger, T., Villacreses, N., Hovda, J., Bosetti, F., Weerasinghe, G. R., Wine, R. N., Harry, G., & Rapoport, S. I. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02246.x · Cited by 123 · see citing works
Self-citation85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain
Rintala, J., Seemann, R., Chandrasekaran, K., Rosenberger, T. A., Chang, L., Contreras, M. A., Rapoport, S. I., & Chang, M. (1999) · Neuroreport · doi:10.1097/00001756-199912160-00030 · Cited by 121 · see citing works
Self-citationAltered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients
Kim, H., Рапопорт, С. И., & Rao, J. S. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.137 · Cited by 121 · see citing works
Self-citationIn vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism
Rapoport, S. I. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00399-8 · Cited by 109 · see citing works
Self-citationHauss‐Wegrzyniak, B., Lukovic, L., Bigaud, M., & Stoeckel, M. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00227-3 · Cited by 108 · see citing works
Rosenberger, T. A., Villacreses, N. E., Hovda, J. T., Bosetti, F., Weerasinghe, G. R., Wine, R. N., Harry, G. J., & Rapoport, S. I. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02613.x · Cited by 105 · see citing works
Self-citationLithium improves HIV-associated neurocognitive impairment
Letendre, S. L., Woods, S. P., Ellis, R. J., Atkinson, J. H., Masliah, E., van den Brande, G., Durelle, J., Grant, I., & Everall, I. (2006) · AIDS · doi:10.1097/01.aids.0000244208.49123.1b · Cited by 103 · see citing works
Chang, M., Bell, J. M., Purdon, A. D., Chikhale, E. G., & Grange, E. (1999) · Neurochemical Research · doi:10.1023/a:1020989701330 · Cited by 96 · see citing works
Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates
Gleissman, H., Yang, R., Martinod, K., Lindskog, M., Serhan, C. N., Johnsen, J. I., & Kogner, P. (2009) · The FASEB Journal · doi:10.1096/fj.09-137919 · Cited by 90 · see citing works
Hong, S., Tjonahen, E., Morgan, E. L., Lu, Y., Serhan, C. N., & Rowley, A. F. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.04.004 · Cited by 84 · see citing works
Farias, S., Basselin, M., Chang, L., Heidenreich, K. A., Rapoport, S. I., & Murphy, R. C. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800200-jlr200 · Cited by 80 · see citing works
Self-citationRelation Between Free Fatty Acid and Acyl-CoA Concentrations in Rat Brain Following Decapitation
Deutsch, J., Рапопорт, С. И., & Purdon, A. D. (1997) · Neurochemical Research · doi:10.1023/a:1022030306359 · Cited by 77 · see citing works
Vanderhoek, J. Y., & Bailey, J. M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39792-2 · Cited by 75 · see citing works
Stolk, P., Souverein, P. C., Wilting, I., Leufkens, H. G. M., Klein, D. F., Rapoport, S. I., & Heerdink, E. R. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.10.007 · Cited by 71 · see citing works
Self-citationA small-gauge cannula device for continuous infusion of exogenous agents into the brain
Williams, L. R., Vahlsing, H. L., Lindamood, T. E., Varon, S. S., Gage, F. H., & Manthorpe, M. (1987) · Experimental Neurology · doi:10.1016/0014-4886(87)90313-x · Cited by 68 · see citing works
Dangi, B., Obeng, M., Nauroth, J. M., Teymourlouei, M., Needham, M., Raman, K. P., & Arterburn, L. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809014200 · Cited by 68 · see citing works
Elander, L., Engström, L., Hallbeck, M., & Blomqvist, A. G. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00511.2006 · Cited by 67 · see citing works
Bazinet, R. P., Lee, H., Felder, C. C., Porter, A. C., Rapoport, S. I., & Rosenberger, T. A. (2005) · Neurochemical Research · doi:10.1007/s11064-005-2746-5 · Cited by 67 · see citing works
Self-citationFrequency of bipolar spectrum in 111 private practice depression outpatients
Benazzi, F. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0433-6 · Cited by 63 · see citing works
Distribution of calcium-independent phospholipase A2 (iPLA2) in monkey brain
Ong, W., Yeo, J.-F., Ling, S.-F., & Farooqui, A. A. (2005) · Journal of Neurocytology · doi:10.1007/s11068-006-8730-4 · Cited by 57 · see citing works
Basselin, M., Villacreses, N. E., Lee, H., Bell, J. M., & Rapoport, S. I. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04593.x · Cited by 56 · see citing works
Self-citationWeerasinghe, G. R., Rapoport, S. I., & Bosetti, F. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.04.005 · Cited by 51 · see citing works
Self-citationArachidonate Release and Eicosanoid Generation by Group IIE Phospholipase A2
Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G. J., Singer, A. G., Gelb, M. H., Sawada, M., Inagaki, N., Nagai, H., & Kudo, I. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6716 · Cited by 51 · see citing works
Lipoxygenation of Docosahexaenoic Acid by the Rat Pineal Body
Sawazaki, S., Salem, N., & Kim, H. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62062437.x · Cited by 49 · see citing works
Self-citationMurphy, E. J. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.07.005 · Cited by 47 · see citing works
EFFECTS OF BACTERIAL ENDOTOXIN ON WATER INTAKE, FOOD INTAKE, AND BODY TEMPERATURE IN THE ALBINO RAT
Holmes, J., & Miller, N. E. (1963) · The Journal of Experimental Medicine · doi:10.1084/jem.118.4.649 · Cited by 43 · see citing works
Szupera, Z., Mezei, Z., Kis, B., Gecse, Á., Vécsei, L., & Telegdy, G. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00764-5 · Cited by 29 · see citing works
5-Hydroxyeicosatetraenoic acid and human parturition
Edwin, S. S., Romero, R. J., Muñoz, H., Branch, D. W., & Mitchell, M. D. (1996) · Prostaglandins · doi:10.1016/0090-6980(96)00046-9 · Cited by 26 · see citing works
Richardson, R. L., Kim, E.-M., Gardiner, T. A., & O‘Hare, E. (2005) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000179278.03868.96 · Cited by 22 · see citing works
Butovich, I. A., Hámberg, M., & Rådmark, O. (2005) · Lipids · doi:10.1007/s11745-005-1379-z · Cited by 19 · see citing works
Marriott, L. K., McGann-Gramling, K. R., Hauss‐Wegrzyniak, B., Sheldahl, L. C., Shapiro, R. A., Dorsa, D. M., & Wenk, G. L. (2006) · Endocrinology · doi:10.1210/en.2006-0642 · Cited by 17 · see citing works
Rosenberger, T. A., Villacreses, N. E., Weis, M. T., & Rapoport, S. I. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.12.010 · Cited by 11 · see citing works
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Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Inflamed moods: A review of the interactions between inflammation and mood disorders
Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609 · see citing works
Lithium: A review of pharmacology, clinical uses, and toxicity
Oruch, R., Elderbi, M., Khattab, H. A., Pryme, I. F., & Lund, A. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.042 · Cited by 220 · see citing works
Effects of Lithium on Inflammation
Nassar, A., & Azab, A. N. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500038f · Cited by 218 · see citing works
Patel, J. P., & Frey, B. N. (2015) · Neural Plasticity · doi:10.1155/2015/708306 · Cited by 182 · see citing works
Bipolar disorder and mechanisms of action of mood stabilizers
Rapoport, S. I., Basselin, M., Kim, H., & Rao, J. S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.06.003 · Cited by 155 · see citing works
Self-citationElevated immune-inflammatory signaling in mood disorders: a new therapeutic target?
McNamara, R. K., & Lotrich, F. E. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.98 · Cited by 109 · see citing works
Therapeutic use of omega-3 fatty acids in bipolar disorder
Balanzá‐Martínez, V., Fries, G. R., Colpo, G. D., Silveira, P. P., Portella, A. K., Tabarés‐Seisdedos, R., & Kapczinski, F. P. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.42 · Cited by 104 · see citing works
Arabzadeh, S., Ameli, N., Zeinoddini, A., Rezaei, F., Farokhnia, M., Mohammadinejad, P., Ghaleiha, A., & Akhondzadeh, S. (2015) · Bipolar Disorders · doi:10.1111/bdi.12324 · Cited by 100 · see citing works
Improving Lithium Therapeutics by Crystal Engineering of Novel Ionic Cocrystals
Smith, A. J., Kim, S.-H., Duggirala, N. K., Jin, J., Wojtas, Ł., Ehrhart, J. C., Giunta, B. N., Tan, J., Zaworotko, M. J., & Shytle, R. D. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400571a · Cited by 88 · see citing works
Sethi, R., Gómez‐Coronado, N., Walker, A. J., Robertson, O. D., Agustini, B., Berk, M., & Dodd, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00605 · Cited by 88 · see citing works
Rapoport, S. I. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500058v · Cited by 78 · see citing works
Self-citationThe NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium
Ghasemi, M., & Dehpour, A. R. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.03.006 · Cited by 77 · see citing works
Kerr, F., Bjedov, I., & Sofola-Adesakin, O. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00297 · Cited by 78 · see citing works
Mousavi, S. Y., Khezri, R., Karkhaneh-Yousefi, M.-A., Mohammadinejad, P., Gholamian, F., Mohammadi, M. R., Zeinoddini, A., & Akhondzadeh, S. (2017) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2016.0207 · Cited by 61 · see citing works
Tian, H., Lü, Y., Shah, S. P., & Hong, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100388 · Cited by 58 · see citing works
Adjunct Treatments for Schizophrenia and Bipolar Disorder: What to Try When You Are Out of Ideas
Torrey, E. F., & Davis, J. M. (2011) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.5.4.5 · Cited by 56 · see citing works
Keleshian, V. L., Modi, H. R., Rapoport, S. I., & Rao, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12153 · Cited by 54 · see citing works
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Ghanaatfar, F., Ghanaatfar, A., Isapour, P., Farokhi, N., Bozorgniahosseini, S., Javadi, M., Gholami, M., Ulloa, L., Coleman‐Fuller, N., & Motaghinejad, M. (2022) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12826 · Cited by 51 · see citing works
Taha, A. Y., Blanchard, H. C., Cheon, Y., Ramadan, E., Chen, M., Chang, L., & Rapoport, S. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9968-1 · Cited by 49 · see citing works
Self-citationKim, H., Rao, J. S., Rapoport, S. I., & Igarashi, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.10.005 · Cited by 48 · see citing works
Self-citationLe-Niculescu, H., Case, N. J., Hulvershorn, L. A., Patel, S. D., Bowker, D., Gupta, J., Bell, R. L., Edenberg, H. J., Tsuang, M. T., Kuczenski, R. T., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.1 · Cited by 48 · see citing works
Basselin, M., Ramadan, E., & Rapoport, S. I. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.12.001 · Cited by 43 · see citing works
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Maddu, N., & Raghavendra, P. B. (2015) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2014.998369 · Cited by 39 · see citing works
Tian, H., Lu, Y., Shah, S. P., & Hong, S. (2011) · American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.026 · Cited by 30 · see citing works
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Baranovskaya, I. L., Volk, K., Alexander, S. A., Abais‐Battad, J. M., & Mamenko, M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1399396 · Cited by 3 · see citing works
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Cerebrovascular Disease and Bipolar Disorder
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Introduction: More Than 50 Years of Research on Polyunsaturated Fatty Acid Metabolism
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Relação entre o tratamento crônico com lítio e papel do sistema colinérgico na neuroinflamação.
Schöwe, N. M. (2013) · doi:10.11606/d.42.2013.tde-11062014-145521 · Cited by 1 · see citing works
Rinaudo, L., & Hopwood, M. (2015) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2015.02.004
Westacott, L. J., Dec, K., Gruszczyńska, H., Joyce, C., Mitchell, S., Hall, J., & Harwood, A. J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1929742
- Authors
- Basselin, M., Kim, H.-W., Chen, M., Ma, K., Rapoport, S. I., Murphy, R. C., & Farias, S. E.
- Affiliations
- National Institutes of Health (US)
- University of Colorado Denver (US)
- Corresponding author
- Basselin, Mireille
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 51
- Issue
- 5
- Pages
- 1049-1056
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC2853431
- OpenAlex
- W2093308618
- Cited by
- 52
- References
- 67
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- erratum (2018-08-01)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (GM-069338)
- National Institute on Aging
- National Institute of General Medical Sciences (U54GM069338, GM 069338)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- lithium, neuroinflammation, lipopolysaccharide, arachidonic acid metabolism, docosahexaenoic acid, eicosanoids, docosanoids, prostaglandin E2, phospholipase A2, lipoxygenase, docosapentaenoic acid, intracerebroventricular infusion, brain lipid metabolism
- MeSH terms
- Animals, Anti-Inflammatory Agents, Bipolar Disorder, Body Weight, Brain, Catheterization, Dietary Fats, Docosahexaenoic Acids, Dose-Response Relationship, Drug, Esterification, Inflammation, Lipopolysaccharides, Lithium, Male, Microwaves, Time Factors, Arachidonic Acid, Rats
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