PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population

Postmus, Iris; Trompet, Stella; de Craen, Anton J.M.; Buckley, Brendan M.; Ford, Ian; Stott, David J.; Sattar, Naveed; Slagboom, P. Eline; Westendorp, Rudi G.J.; Jukema, J. Wouter

doi:10.1194/jlr.m033969

PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population

Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a protein involved in LDL-cholesterol metabolism. The single-nucleotide polymorphism (SNP) rs11591147 has been associated with lower LDL-cholesterol and a lower risk of coronary heart disease. Because PCSK9 has high affinity to the LDL…