Cited by 163Lipid metabolism and disordersLipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

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Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study

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Lai, Chao-Qiang, Demissie, Serkalem, Cupples, L. Adrienne, Zhu, Yueping, Adiconis, Xian, Parnell, Laurence D., Corella, Dolores, Ordovas, Jose M.·2004·Journal of Lipid Research

DOI 10.1194/jlr.m400192-jlr200

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Abstract

Several polymorphisms in the APOA5 gene have been associated with increased plasma triglyceride (TG) concentrations. However, associations between APOA5 and lipoprotein subclasses, remnant-like particles (RLPs), and cardiovascular disease (CVD) risk have been less explored. We investigated associations of five APOA5 single-nucleotide polymorphisms (SNPs; -1131T>C, -3A>G, 56C>G IVS3+ 476G>A, and 1259T>C) with lipoprotein subfractions and CVD risk in 1,129 men and 1,262 women participating in the Framingham Heart Study. Except for the 56C>G SNP, the other SNPs were in significant linkage disequilibria, resulting in three haplotypes (11111, 22122, and 11211) representing 98% of the population. SNP analyses revealed that the -1131T>C and 56C>G SNPs were significantly associated with higher plasma TG concentrations in both men and women. For RLP and lipoprotein subclasses, we observed gender-specific association for the -1131T>C and 56C>G SNPs. Female carriers of the -1131C allele had higher RLP concentrations, whereas in males, significant associations for RLPs were observed for the 56G allele. Moreover, haplotype analyses confirmed these findings and revealed that the 22122 and 11211 haplotypes exhibited different associations with HDL cholesterol concentrations. In women, the -1131C allele was associated with a higher hazard ratio for CVD (1.85; 95% confidence interval, 1.03-3.34; P = 0.04), in agreement with the association of this SNP with higher RLPs.

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Improved Prediction of Signal Peptides: SignalP 3.0
Dyrløv Bendtsen, J., Nielsen, H., von Heijne, G., & Brunak, S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.028 · Cited by 6,350
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
The PSIPRED protein structure prediction server
McGuffin, L. J., Bryson, K., & Jones, D. T. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.4.404 · Cited by 3,887
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.
(1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040269 · Cited by 1,950
Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion
den Dunnen, J. T., & Antonarakis, S. E. (2000) · Human Mutation · doi:10.1002/(sici)1098-1004(200001)15:1 · Cited by 1,757
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
Combining evolutionary information and neural networks to predict protein secondary structure
Rost, B., & Sander, C. (1994) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340190108 · Cited by 1,443
Genetic Data Analysis
Weir, B. S. (1990) · Cited by 1,401
The framingham offspring study. Design and preliminary data
Feinleib, M., Kannel, W. B., Garrison, R. J., McNamara, P. M., & Castelli, W. P. (1975) · Preventive Medicine · doi:10.1016/0091-7435(75)90037-7 · Cited by 926
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921
Application of multiple sequence alignment profiles to improve protein secondary structure prediction
Cuff, J. A., & Barton, G. J. (2000) · Proteins Structure Function and Bioinformatics · doi:10.1002/1097-0134(20000815)40:3 · Cited by 773
Development of a Proton Nuclear Magnetic Resonance Spectroscopic Method for Determining Plasma Lipoprotein Concentrations and Subspecies Distributions from a Single, Rapid Measurement
Otvos, J. D., Jeyarajah, E. J., Bennett, D. W., & Krauss, R. M. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.9.1632 · Cited by 420
Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apo B-100 and anti apo A-I immunoaffinity mixed gels
Nakajima, K., SAITO, T., Tamura, A., Suzuki, M., Nakano, T., Adachi, M., Tanaka, A., Tada, N., Nakamura, H., Campos, E. M., et al. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90062-9 · Cited by 417
Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels
Pennacchio, L. A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.24.3031 · Cited by 381
Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides
Talmud, P. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.24.3039 · Cited by 365
Postprandial lipoprotein metabolism and atherosclerosis.
Karpe, F. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00548.x · Cited by 360
Relation of Lipoprotein Subclasses as Measured by Proton Nuclear Magnetic Resonance Spectroscopy to Coronary Artery Disease
Freedman, D. S., Otvos, J. D., Jeyarajah, E. J., Barboriak, J. J., Anderson, A. J., & Walker, J. A. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.7.1046 · Cited by 345
Apolipoprotein A-V
van der Vliet, H. N., Groenink, M., Leegwater, A. C. J., Levels, J. H. M., Reitsma, P. H., BOERS, W., & Chamuleau, R. A. F. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106888200 · Cited by 344
ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis
Schaap, F. G., Rensen, P. C. N., Voshol, P. J., Vrins, C. L. J., van der Vliet, H. N., Chamuleau, R. A. F. M., Havekes, L. M., Groen, A. K., & van Dijk, K. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403240200 · Cited by 307
Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study
McNamara, J. R. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00484-6 · Cited by 278
Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.
Li, W. W., Dammerman, M. M., Smith, J. D., Metzger, S., Breslow, J. L., & Leff, T. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118324 · Cited by 278
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism
Preiss-Landl, K., Zimmermann, R., Hämmerle, G., & Zechner, R. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200210000-00002 · Cited by 246
Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals
Fielding, B., Callow, J., Owen, R., Samra, J. S., Dr, M., & Frayn, K. N. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.1.36 · Cited by 224
Apolipoprotein A5, a Crucial Determinant of Plasma Triglyceride Levels, Is Highly Responsive to Peroxisome Proliferator-activated Receptor α Activators
Vu‐Dac, N., Gervois, P. P., Jäkel, H., Nowak, M., Baugé, E., Dehondt, H., Staels, B., Pennacchio, L. A., Rubin, E. M., Fruchart‐Najib, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212191200 · Cited by 210
Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5
Fruchart‐Najib, J., Baugé, E., Niculescu, L. S., Pham, T., Thomas, B., Rommens, C., Majd, Z., Brewer, B., Pennacchio, L. A., & Fruchart, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.003 · Cited by 203
The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-α and Contains a Novel Farnesoid X-activated Receptor Response Element
Prieur, X., Coste, H., & Rodríguez, J. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301302200 · Cited by 194
Long- and short-term risk of sudden coronary death.
Cupples, L. A., GAGNON, D. R., & Wb, K. (1992) · PubMed · Cited by 191
Self-citation
Properties of an apolipoprotein E-enriched fraction of triglyceride-rich lipoproteins isolated from human blood plasma with a monoclonal antibody to apolipoprotein B-100.
Campos, E. M., Nakajima, K., Tanaka, A., & Havel, R. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41527-5 · Cited by 185
Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue.
Ong, J. M., & Kern, P. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114155 · Cited by 158
Structure and Interfacial Properties of Human Apolipoprotein A-V
Weinberg, R. B., Cook, V. R., Beckstead, J. A., Martin, D. D. O., Gallagher, J. W., Shelness, G. S., & Ryan, R. O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303784200 · Cited by 158
A risk factor for atherosclerosis: triglyceride-rich lipoproteins.
Mj, M., & Jp, K. (2001) · PubMed · Cited by 141
The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore
Lai, C., Tai, E. S., Tan, C. E., Cutter, J. L., Chew, S. K., Zhu, Y., Adiconis, X., & Ordovás, J. M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300251-jlr200 · Cited by 138
Self-citation
Triglycerides and atherogenic lipoproteins: rationale for lipid management
Krauss, R. M. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00213-7 · Cited by 137
The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese
Nabika, T., Nasreen, S., Kobayashi, S., & Masuda, J. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00252-6 · Cited by 135
Elevated Remnant-Like Particle Cholesterol and Triglyceride Levels in Diabetic Men and Women in the Framingham Offspring Study
Schaefer, E. J., McNamara, J. R., Shah, P. K., Nakajima, K., Cupples, L. A., Ordovás, J. M., & Wilson, P. W. F. (2002) · Diabetes Care · doi:10.2337/diacare.25.6.989 · Cited by 134
Self-citation
Newly Identified Apolipoprotein AV Gene Predisposes to High Plasma Triglycerides in Familial Combined Hyperlipidemia
Ribalta, J., Figuera, L., Fernandez-Ballart, J. D., Vilella, E., Cabezas, M. C., Masana, L., & Joven, J. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.9.1597 · Cited by 131
Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren
Endo, K., Yanagi, H., Araki, J., Hirano, C., Yamakawa‐Kobayashi, K., & Tomura, S. (2002) · Human Genetics · doi:10.1007/s00439-002-0825-0 · Cited by 123
Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges
Martin, S., Nicaud, V., Humphries, S. E., & Talmud, P. J. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(03)00033-4 · Cited by 119
Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids
Aouizerat, B. E., Kulkarni, M. V., Heilbron, D. C., Drown, D. J., Raskin, S., Pullinger, C. R., Malloy, M. J., & Kane, J. P. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200480-jlr200 · Cited by 118
Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study
McNamara, J. R., Shah, P. K., Nakajima, K., Cupples, L. A., Wilson, P. W. F., Ordovás, J. M., & Schaefer, E. J. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.6.1224 · Cited by 105
Self-citation
Linkage and Association Between Distinct Variants of the APOA1/C3/A4/A5 Gene Cluster and Familial Combined Hyperlipidemia
Eichenbaum‐Voline, S., Olivier, M., Jones, E. L., Naoumova, R. P., Jones, B., Gau, B. C., Patel, H., Seed, M., Betteridge, D. J., Galton, D. J., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099881.83261.d4 · Cited by 102
Association of the APOLIPOPROTEIN A1/C3/A4/A5 Gene Cluster With Triglyceride Levels and LDL Particle Size in Familial Combined Hyperlipidemia
Mar, R., Pajukanta, P., Allayee, H., Groenendijk, M., Dallinga‐Thie, G. M., Krauss, R. M., Sinsheimer, J. S., Cantor, R. M., de Bruin, T. W., & Lusis, A. J. (2004) · Circulation Research · doi:10.1161/01.res.0000124922.61830.f0 · Cited by 101
The −1131T→C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men
Jang, Y., Kim, J. Y., Kim, O. Y., Lee, J. E., Cho, H., Ordovás, J. M., & Lee, J. H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.832 · Cited by 97
Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11
Olivier, M., Wang, X., Cole, R., Gau, B. C., Kim, J. J., Rubin, E. M., & Pennacchio, L. A. (2004) · Genomics · doi:10.1016/j.ygeno.2003.11.016 · Cited by 90
Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine
Tso, P., Drake, D. S., Black, D. D., & Sabesin, S. M. (1984) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1984.247.6.g599 · Cited by 89
Analysis of Apolipoprotein A5, C3, and Plasma Triglyceride Concentrations in Genetically Engineered Mice
Baroukh, N., Baugé, E., Akiyama, J. A., Chang, J. J. ‐., Afzal, V., Fruchart, J., Rubin, E. M., Fruchart‐Najib, J., & Pennacchio, L. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000130463.68272.1d · Cited by 82
The familial periodic paralyses and nondystrophic myotonias
Ptáček, L. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00123-5 · Cited by 82
Nutritional regulation of lipoprotein lipase in guinea pig tissues
Semb, H., & Olivecrona, T. (1986) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(86)90281-x · Cited by 61
Remnant-like lipoprotein particle cholesterol concentration and progression of coronary and vein-graft atherosclerosis in response to gemfibrozil treatment.
Karpe, F. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00700-0 · Cited by 50
The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster
Clark, A. G., Nickerson, D. A., Weiss, K. M., Salomaa, V. V., Boerwinkle, E., Fullerton, S. M., Buchanan, A. V., Sonpar, V. A., Steng�rd, J. H., Smith, J. D., et al. (2004) · Human Genetics · doi:10.1007/s00439-004-1106-x · Cited by 48
Plasma remnant-like particle lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects
Marcoux, C., Tremblay, M., Fredenrich, A., Jacques, H., Krimbou, L., Nakajima, K., Davignon, J., & Cohn, J. S. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00042-2 · Cited by 45
Triglycerides: risk factor or fellow traveler?
Forrester, J. S. (2001) · Current Opinion in Cardiology · doi:10.1097/00001573-200107000-00007 · Cited by 40
Association of remnant-like particle cholesterol with coronary artery disease in patients with normal total cholesterol levels
Masuoka, H., Kamei, S., Wagayama, H., Ozaki, M., Kawasaki, A., Tanaka, T., Kitamura, M., Katoh, S., Shintani, U., Misaki, M., et al. (2000) · American Heart Journal · doi:10.1016/s0002-8703(00)90240-0 · Cited by 40
The Apolipoprotein AV Gene and Diurnal Triglyceridaemia in Normolipidaemic Subjects
Masana, L., Ribalta, J., Salazar, J., Fernandez-Ballart, J. D., Joven, J., & Cabezas, M. C. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.078 · Cited by 39
Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma
Campos, E. M., Kotite, L., Blanche, P. J., Mitsugi, Y., Frost, P. H., Masharani, U. B., Krauss, R. M., & Havel, R. J. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30142-5 · Cited by 28
Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons
Wang, Q. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh121 · Cited by 28
Genetic heterogeneity in the apolipoprotein C-III promoter and effects of insulin
Dallinga‐Thie, G. M., Groenendijk, M., Blom, R. N. H. H. C., de Bruin, T. W., & de Kant, E. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30278-9 · Cited by 27
Plasma triglyceride-rich lipoprotein remnants as a risk factor of ‘Pokkuri disease’
Takeichi, S., Nakajima, Y., Yukawa, N., Saito, T., Seto, Y., Huang, X.-L., Kusakabe, T., Jin, Z.-B., Hasegawa, I., Nakano, T., et al. (2001) · Legal Medicine · doi:10.1016/s1344-6223(01)00010-4 · Cited by 25
Allele-specific Differences in Apolipoprotein C-III mRNA Expression in Human Liver
Esterbauer, H., Hell, E., Krempler, F., & Patsch, W. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.3.331 · Cited by 24
Remnant-Like Particle Cholesterol Levels in Korean Patients with Coronary Artery Disease and Non-Insulin Dependent Diabetes Mellitus
Song, J., Park, H., Hong, S. H., Lee, H. K., Park, Y. B., & Kim, J. Q. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.062 · Cited by 9

Research works printed but not linked: 1

Nakajima, 1996, Separation and determination of remnant-like particles in human serum using monoclonal antibodies to apo B and apo A-I, J. Clin. Ligand., 19, 177

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Authors: Lai, C.-Q., Demissie, S., Cupples, L. A., Zhu, Y., Adiconis, X., Parnell, L. D., Corella, D., & Ordovas, J. M.
Affiliations: Tufts University (US)
Boston University (US)
Corresponding author: Lai, Chao-Qiang
ORCID: Lai, Chao-Qiang
Demissie, Serkalem
Cupples, L. Adrienne
Zhu, Yueping
Adiconis, Xian
Parnell, Laurence D.
Corella, Dolores
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2004-11
Volume: 45
Issue: 11
Pages: 2096-2105
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.m400192-jlr200
OpenAlex: W2154292243
Cited by: 163
References: 59
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 1 · 2012: 11
FWCI: 9.82
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5788 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Heart, Lung, and Blood Institute (HL54776, R01HL054776)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: APOA5, apolipoprotein A-I, single nucleotide polymorphisms, plasma triglycerides, remnant-like particles, lipoprotein subclasses, cardiovascular risk, HDL cholesterol, haplotypes, linkage disequilibrium, sex differences, Framingham Heart Study
MeSH terms: Apolipoprotein A-V, Adult, Aged, Alleles, Apolipoproteins, Apolipoproteins A, Cardiovascular Diseases, Cardiovascular System, Cholesterol, Coronary Disease, Female, Genotype, Haplotypes, Humans, Lipoproteins, Male, Middle Aged, Polymorphism, Genetic, Risk, Sex Factors, Triglycerides, Genetic Variation, Linkage Disequilibrium, Polymorphism, Single Nucleotide

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Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study

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