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Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study
Open accessAbstract
Several polymorphisms in the APOA5 gene have been associated with increased plasma triglyceride (TG) concentrations. However, associations between APOA5 and lipoprotein subclasses, remnant-like particles (RLPs), and cardiovascular disease (CVD) risk have been less explored. We investigated associations of five APOA5 single-nucleotide polymorphisms (SNPs; -1131T>C, -3A>G, 56C>G IVS3+ 476G>A, and 1259T>C) with lipoprotein subfractions and CVD risk in 1,129 men and 1,262 women participating in the Framingham Heart Study. Except for the 56C>G SNP, the other SNPs were in significant linkage disequilibria, resulting in three haplotypes (11111, 22122, and 11211) representing 98% of the population. SNP analyses revealed that the -1131T>C and 56C>G SNPs were significantly associated with higher plasma TG concentrations in both men and women. For RLP and lipoprotein subclasses, we observed gender-specific association for the -1131T>C and 56C>G SNPs. Female carriers of the -1131C allele had higher RLP concentrations, whereas in males, significant associations for RLPs were observed for the 56G allele. Moreover, haplotype analyses confirmed these findings and revealed that the 22122 and 11211 haplotypes exhibited different associations with HDL cholesterol concentrations. In women, the -1131C allele was associated with a higher hazard ratio for CVD (1.85; 95% confidence interval, 1.03-3.34; P = 0.04), in agreement with the association of this SNP with higher RLPs.
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“The minor allele of rs3135506 (minor allele frequency (MAF) of about 6% in whites) has been repeatedly associated with increased plasma TG concentrations [96–99].”
From Fenofibrate and metabolic syndrome (2010) · cites this paper as [97]
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Cites
Improved Prediction of Signal Peptides: SignalP 3.0
Dyrløv Bendtsen, J., Nielsen, H., von Heijne, G., & Brunak, S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.028 · Cited by 6,350
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
The PSIPRED protein structure prediction server
McGuffin, L. J., Bryson, K., & Jones, D. T. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.4.404 · Cited by 3,887
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.
(1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040269 · Cited by 1,950
Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion
den Dunnen, J. T., & Antonarakis, S. E. (2000) · Human Mutation · doi:10.1002/(sici)1098-1004(200001)15:1 · Cited by 1,757
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
Combining evolutionary information and neural networks to predict protein secondary structure
Rost, B., & Sander, C. (1994) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340190108 · Cited by 1,443
Weir, B. S. (1990) · Cited by 1,401
The framingham offspring study. Design and preliminary data
Feinleib, M., Kannel, W. B., Garrison, R. J., McNamara, P. M., & Castelli, W. P. (1975) · Preventive Medicine · doi:10.1016/0091-7435(75)90037-7 · Cited by 926
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921
Research works printed but not linked: 1
- Nakajima, 1996, Separation and determination of remnant-like particles in human serum using monoclonal antibodies to apo B and apo A-I, J. Clin. Ligand., 19, 177
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Sarwar, N., Danesh, J., Eiriksdottir, G., Sigurdsson, G., Wareham, N., Bingham, S., Boekholdt, S. M., Khaw, K.-T., & Gudnason, V. (2007) · Circulation · doi:10.1161/circulationaha.106.637793 · Cited by 1,408
Jørgensen, A. B., Frikke-Schmidt, R., West, A. S., Grande, P., Nordestgaard, B. G., & Tybjærg-Hansen, A. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs431 · Cited by 501
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
Kathiresan, S., Manning, A. K., Demissie, S., D’Agostino, R. B., Surti, A., Guiducci, C., Gianniny, L., Burtt, N. P., Melander, O., Orho‐Melander, M., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s17 · Cited by 338
Self-citationOrho‐Melander, M., Melander, O., Guiducci, C., Pérez‐Martínez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M. J., Hall, J. L., Abecasis, G. R., et al. (2008) · Diabetes · doi:10.2337/db08-0516 · Cited by 301
Self-citationMerkel, M., Loeffler, B., Kluger, M. A., Fabig, N., Geppert, G., Pennacchio, L. A., Laatsch, A., & Heeren, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411412200 · Cited by 292
Metadata
- Authors
- Lai, C.-Q., Demissie, S., Cupples, L. A., Zhu, Y., Adiconis, X., Parnell, L. D., Corella, D., & Ordovas, J. M.
- Affiliations
- Tufts University (US)
- Boston University (US)
- Corresponding author
- Lai, Chao-Qiang
- ORCID
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 45
- Issue
- 11
- Pages
- 2096-2105
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2154292243
- Cited by
- 163
- References
- 59
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 1 · 2012: 11
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Heart, Lung, and Blood Institute (HL54776, R01HL054776)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- APOA5, apolipoprotein A-I, single nucleotide polymorphisms, plasma triglycerides, remnant-like particles, lipoprotein subclasses, cardiovascular risk, HDL cholesterol, haplotypes, linkage disequilibrium, sex differences, Framingham Heart Study
- MeSH terms
- Apolipoprotein A-V, Adult, Aged, Alleles, Apolipoproteins, Apolipoproteins A, Cardiovascular Diseases, Cardiovascular System, Cholesterol, Coronary Disease, Female, Genotype, Haplotypes, Humans, Lipoproteins, Male, Middle Aged, Polymorphism, Genetic, Risk, Sex Factors, Triglycerides, Genetic Variation, Linkage Disequilibrium, Polymorphism, Single Nucleotide
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