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Regulation of reconstituted high density lipoprotein structure and remodeling by apolipoprotein E
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These larger particles that are formed due to particle fusion are predicted to contain 6 ApoE molecules per particle with a diameter ~ 13-15 nm and thus would also be predicted to have higher avidity to ApoE receptors.
“These larger particles that are formed due to particle fusion are predicted to contain 6 ApoE molecules per particle with a diameter ~ 13–15 nm and thus would also be predicted to have higher avidity to ApoE receptors.”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [78]
Our copy says CETP-mediated fusion generated larger apoE-containing rHDLs and treats six apoE molecules per fused particle as an assumption in its surface-area calculation (passages labeled Abstract; page unavailable). The retrieved text does not establish a 13–15 nm diameter for those fusion products or predict that they have higher avidity for apoE receptors. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIncubation of spherical ApoE with CETP results in the generation of larger spherical particles due to particle fusion.
“Incubation of spherical ApoE with CETP results in the generation of larger spherical particles due to particle fusion [78].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [78]
LCAT may be easily dissociated from ApoE lipoprotein.
“suggesting that it may be easily dissociated from ApoE lipoprotein (94).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [94]
ApoE has significantly less affinity for LCAT than ApoA1.
“ApoE has also been reported to have significantly less affinity for LCAT than ApoA1”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [94]
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Cites
Human apolipoprotein E. The complete amino acid sequence
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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
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Cited by
Sorted by citations
Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism
Mahley, R. W. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.307023 · Cited by 516
Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteins
Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166195 · Cited by 29
Strickland, M. R., Wang, Z., Golden, L. R., Wang, H., Lu, P., Ren, Y., Tabor, G. T., Zhao, N., Ulrich, J. D., Han, X., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101000 · Cited by 8
Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00970-0
Metadata
- Authors
- Rye, K.-A., Bright, R., Psaltis, M., & Barter, P. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 47
- Issue
- 5
- Pages
- 1025-1036
- ISSN
- 0022-2275
- Cited by
- 33
- References
- 3
- Language
- en
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