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Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
Open accessAbstract
Cold exposure induces brown adipocytes in retroperitoneal fat (RP) of adult A/J mice but not in C57BL/6J (B6) mice. In contrast, induction of the mitochondrial uncoupling protein 1 gene (Ucp1) in interscapular brown adipose tissue (iBAT) shows no strain dependence. We now show that unlike iBAT, in which Ucp1 was expressed in the fetus and continued throughout life, in RP, Ucp1 was transiently expressed between 10 and 30 days of age and then disappeared. Similar to the lack of genetic variation in the expression of Ucp1 in iBAT during cold induction of adult mice, no genetic variation in Ucp1 expression in iBAT was detected during development. In contrast, UCP1-positive multilocular adipocytes, together with corresponding increases in Ucp1 expression, appeared in RP at 10 days of age in A/J and B6 mice, but with much higher expression in A/J mice. At 20 days of age, brown adipocytes represent the major adipocyte present in RP of A/J mice. The disappearance of brown adipocytes by 30 days of age suggested that tissue remodeling occurred in RP. Genetic variability in Ucp1 expression could not be explained by variation in the expression of selective transcription factors and signaling molecules of adipogenesis. In summary, the existence of genetic variability between A/J and B6 mice during the development of brown adipocyte expression in RP, but not in iBAT, suggests that developmental mechanisms for the brown adipocyte differentiation program are different in these adipose tissues.
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“In rodents, small collections of physiologically relevant BAT have been found in the hindlimb in intermuscular adipose tissue and mixed with white fat 86,87.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [87]
In the citing paper
“These systemic brown adipocytes are often found admixed with white fat cells; are more sensitive to β3-adrenergic stimulation and cold exposure; and their thermogenic capacity appears to be regulated by genetic background 86,87,74.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [87]
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Metadata
- Authors
- Xue, B., Rim, J.-S., Hogan, J. C., Coulter, A. A., Koza, R. A., & Kozak, L. P.
- Affiliations
- Pennington Biomedical Research Center (US)
- Corresponding author
- Kozak, Leslie P.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 48
- Issue
- 1
- Pages
- 41-51
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2034958364
- Cited by
- 288
- References
- 55
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 20 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 15 · 2016: 18 · 2015: 25 · 2014: 28 · 2013: 31 · 2012: 19
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-58152, R01DK058152, P30DK072476)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- brown adipocytes, brown adipose tissue, white adipose tissue, retroperitoneal fat, interscapular brown adipose tissue, UCP1, genetic variation, strain differences, cold exposure, adipogenesis, tissue remodeling, A/J mice, C57BL/6J mice, developmental gene expression
- MeSH terms
- Adipose Tissue, Animals, Body Weight, Adipose Tissue, Brown, Cold Temperature, Female, Immunohistochemistry, Male, Mice, Inbred A, RNA, Genetic Variation, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Mice
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